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Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance

Primary Purpose

Vaccine Refusal

Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Trust boost
Sponsored by
University of Essex
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Vaccine Refusal focused on measuring COVID-19 vaccination acceptance, vaccine hesitancy, trust, health inequality, racial/ethnicity

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

Exclusion Criteria:

  • if participants complete the study in less than 5 minutes
  • if participants complete the study without paying attention (as indicated by their answers to two attention check questions)

Sites / Locations

  • Qualtrics. The data is gathered via an online platform.

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm 7

Arm 8

Arm 9

Arm 10

Arm 11

Arm 12

Arm 13

Arm 14

Arm 15

Arm 16

Arm Type

No Intervention

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

Control sender + control content

Control sender + Low trust boost content

Control sender + Medium trust boost content

Control sender+ high trust boost content

Low trust boost Sender + control content

Low trust boost Sender + low trust boost content

Low trust boost Sender + medium trust boost content

Low trust boost sender + high trust boost content

Medium trust boost Sender + control content

Medium trust boost sender + low trust boost content

Medium trust boost sender + Medium trust boost content

Medium trust boost Sender+ high trust boost content

High trust boost sender + control content

High trust boost sender + low trust boost content

High trust boost Sender + medium trust boost content

High trust boost sender + high trust boost content

Arm Description

Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar

Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar

Outcomes

Primary Outcome Measures

Trust perception
Perceived trustworthiness of the vaccine invitation. Participants will rate how trustworthy is the invitation message on a 5 point Likert scale (1: Untrustworthy 3: Not sure, 5: Trustworthy)
Vaccination appointment booking
Likelihood to book a vaccination appointment via the message. Participants will report if they would use the link in the message to book their vaccination appointment on a 5 point Likert scale (1: No, I would not, 3: Not sure/maybe later, 5: Yes, I would)

Secondary Outcome Measures

Full Information

First Posted
February 1, 2022
Last Updated
May 17, 2022
Sponsor
University of Essex
Collaborators
University of Southern California, Department of Health and Social Care, Kingston University
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1. Study Identification

Unique Protocol Identification Number
NCT05238428
Brief Title
Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance
Official Title
Mind the Vaccination Gap: Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance
Study Type
Interventional

2. Study Status

Record Verification Date
May 2022
Overall Recruitment Status
Completed
Study Start Date
February 3, 2022 (Actual)
Primary Completion Date
February 28, 2022 (Actual)
Study Completion Date
March 5, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Essex
Collaborators
University of Southern California, Department of Health and Social Care, Kingston University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
With the constant threat of new epidemic waves and the emergence of variants, COVID-19 resilience can only be attained when a sufficient level of immunity is achieved. Yet, in the US and the UK, COVID-19 vaccination campaigns have failed to secure consistent vaccination acceptance in racial/ethnic minority communities. Despite racial/ethnic minorities being more at risk from COVID-19, they are less vaccinated than the White majority. The investigators propose that current vaccination invitation messages are deemed less trustworthy by racial/ethnic minorities than the White majority and that this might partly explain reduced vaccination acceptance. To provide causal evidence of the role of trust and actionable insights, the investigators will experimentally assess the benefits of new invitation messages to receive the COVID-19 booster dose in large, racially/ethnically diverse samples in the US and the UK. Results will evidence how to increase message and source trustworthiness to foster trust and vaccination acceptance across racial/ethnic groups.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Vaccine Refusal
Keywords
COVID-19 vaccination acceptance, vaccine hesitancy, trust, health inequality, racial/ethnicity

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Model Description
In a 4 x 4 experimental design, the investigators will manipulate the content of the vaccination invitation message in within-subject and the message source in between-subjects. Each participant will hence read four versions of the COVID-19 booster vaccination invitation message sent by one of the four possible sources.
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Participants will read and evaluate 4 versions of the vaccination invitation. The condition will be selected randomly by the Qualtrics algorithm (with an even selection rate). The four invitations will be presented to each participant in a random order based on the Qualtrics randomisation algorithm.
Allocation
Randomized
Enrollment
4039 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Control sender + control content
Arm Type
No Intervention
Arm Description
Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Control sender + Low trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Control sender + Medium trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Control sender+ high trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: You are invited to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Low trust boost Sender + control content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Low trust boost Sender + low trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Low trust boost Sender + medium trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Low trust boost sender + high trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Medium trust boost Sender + control content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Medium trust boost sender + low trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Medium trust boost sender + Medium trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
Medium trust boost Sender+ high trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5
Arm Title
High trust boost sender + control content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar
Arm Title
High trust boost sender + low trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar
Arm Title
High trust boost Sender + medium trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar
Arm Title
High trust boost sender + high trust boost content
Arm Type
Experimental
Arm Description
Participants will read the following text in an online survey: As your local GP and a health expert who cares for the local community, I would like to invite you to book your COVID-19 booster vaccination. The vaccine reduces your chance of becoming infected and protects you against severe forms of the illness. It also protects your loved ones by reducing the risk that you infect others. COVID can be severe, don't risk it. This vaccination is especially important for people who are at higher risk from COVID such as older individuals or those from ethnic minorities. Vaccines may cause side effects, but the benefits outweigh the risks. The most common side effects are very mild (e.g., sore arm, a fever) and severe side effects are very rare (e.g., allergic reaction). Click here to book an appointment: accurx.thirdparty.nhs.uk/r/aafwaczmd5 Dr Sanjay Kumar
Intervention Type
Behavioral
Intervention Name(s)
Trust boost
Intervention Description
The investigators adapt the wording of the vaccination invitation to foster trust and increase vaccination acceptance.
Primary Outcome Measure Information:
Title
Trust perception
Description
Perceived trustworthiness of the vaccine invitation. Participants will rate how trustworthy is the invitation message on a 5 point Likert scale (1: Untrustworthy 3: Not sure, 5: Trustworthy)
Time Frame
immediately after intervention
Title
Vaccination appointment booking
Description
Likelihood to book a vaccination appointment via the message. Participants will report if they would use the link in the message to book their vaccination appointment on a 5 point Likert scale (1: No, I would not, 3: Not sure/maybe later, 5: Yes, I would)
Time Frame
immediately after intervention

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Exclusion Criteria: if participants complete the study in less than 5 minutes if participants complete the study without paying attention (as indicated by their answers to two attention check questions)
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Marie Juanchich, PhD
Organizational Affiliation
University of Essex
Official's Role
Study Chair
Facility Information:
Facility Name
Qualtrics. The data is gathered via an online platform.
City
London
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
The data of the study will be shared on the Open Science Framework after publication.
IPD Sharing Time Frame
The data and the study protocol will be shared after the main scientific output is accepted (possibly pending revision). The investigators anticipate this would be early 2023.
IPD Sharing Access Criteria
The data and study protocol will be free to access to the public

Learn more about this trial

Understanding and Overcoming the Racial/Ethnic Inequalities in COVID-19 Vaccination Acceptance

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