Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy (IMAGE-DCM)
Cervical Spondylosis With Myelopathy, Degenerative Cervical Myelopathy
About this trial
This is an interventional other trial for Cervical Spondylosis With Myelopathy focused on measuring Positron Emission Tomography, Magnetic Resonance Imaging
Eligibility Criteria
Inclusion Criteria
- Participant has a diagnosis of DCM, based on a combination of symptoms, signs and conventional MRI findings (Table 2)
- Participant is scheduled for surgical treatment for DCM
- Participant is willing and able to give informed consent for participation in the study;
- Male or Female, aged 18 - 85 years (inclusive);
Exclusion Criteria
The participant may not enter the study if ANY of the following apply:
- Participant unable to give informed consent;
- Participant unable to undergo, or intolerant of MR or PET/MR imaging
- Participant has co-existing or prior neurological disease of the brain, spinal cord, or peripheral nervous system, including but not limited to, Lumbar Canal Stenosis, Multiple Sclerosis, Dementia and Parkinson's Disease.
Contraindications to MRI: These are chiefly the presence of metallic implants that are not known to be MR safe, particularly in terms of movement or substantial heating. Devices that may need to be considered in this context include (this is not an exhaustive list, and this issue will be considered on a case-by-case basis for any implant or external fixation device):
- Cerebral aneurysm clips not known to be MR safe
- Intra-ocular metallic shards
- Cochlear implants
- Automatic cardioverter defibrillators
- Nerve stimulation units
- Other electronic implants, such as cardiac pacemakers
- Orthopedic external fixations
Exclusion Criteria Specific for PET/MR Imaging Stream
In addition, the following exclusion criteria will apply for PET imaging, to reduce implications of exposure to ionising radiation, or interpretation of findings.
- Female patients who are pregnant or breast-feeding
- Participants whose DCM surgery will include the insertion of metallic implants to secure multiple levels of the spine (technically termed 'instrumentation')
- Age <40
4.3.2 Volunteers
Inclusion Criteria
- Participant is willing and able to give informed consent for participation in the study;
- Male or Female, aged 18 - 85 years (inclusive); Exclusion Criteria
The participant may not enter the study if ANY of the following apply:
- Participant unable to give informed consent;
- Participant unable to undergo, or intolerant of MR imaging
- Participant has co-existing or prior neurological disease of the brain, spinal cord, or peripheral nervous system, including but not limited to, Lumbar Canal Stenosis, Multiple Sclerosis, Dementia and Parkinson's Disease.
Sites / Locations
- Cambridge University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
DCM1: MRI Spinal Cord
DCM2: MRI Brain and Spinal Cord
DCM3: [11C]-PIB MR/PET Cervical Spinal Cord
Healthy Volunteer: MRI Brain and Spinal Cord
3T MR Imaging of the cervical spinal cord, before and at 3-6 months after surgery.
3T MR Imaging of the brain and cervical spinal cord, before and at 3-6 months after surgery. A subset will also be invited to undergo 7T MRI Brain and Spinal Cord Imaging.
[11C]PIB PET/MR Imaging of the cervical spinal cord, before and at 3-6 months after surgery.
Age-Matched Healthy Controls will undergo MRI Brain and Spinal Cord. A subset will also be invited to undergo interval imaging at 3-6 months.