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Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation

Primary Purpose

Inflammatory Response, Oxidative Stress, Oxidative Stress Induction

Status
Recruiting
Phase
Not Applicable
Locations
Austria
Study Type
Interventional
Intervention
Nutrition
Sponsored by
University of Vienna
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Inflammatory Response

Eligibility Criteria

18 Years - 40 Years (Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • female human subjects
  • aged 18-40 years
  • no chronical diseases
  • not more than 120 minutes of physical activity per week
  • no regular resistance training within the past 6 months
  • BMI 18.5 - 24.99 kg/m²
  • body fat percentage of at least 20%
  • Exclusion Criteria:
  • contraindications against physical activity
  • anemia
  • fructose or lactose intolerance
  • smoking
  • medications with influence on ROS levels or inflammation
  • allergy or intolerance against intervention food/beverages.

Sites / Locations

  • University of ViennaRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Experimental

Arm Label

Impact of GT, coffee, OJ, PGJ, milk, SSB on exercise induced oxidative stress&inflammation

Impact of choc, bcc, tomato, walnuts, r&w bread on exercise induced oxidative stress&inflammation

Impact of r&p meat, cheese, eggs, tofu, salmon, on exercise induced oxidative stress&inflammation

Arm Description

single consumption of one cup of green tea (GT), coffee, orange juice (OJ), pomegranate juice (PGJ), milk and sugar sweetened beverage (SSB) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects

single consumption of one proportion of dark chocolate (choc), broccoli (bcc), tomatoes, walnuts, white bread and whole grain bread (r = refined & w = whole grain) 2 hours prior to a 30-min-HIIT resistance circuit exercise in healthy human subjects

single consumption of one proportion of red meat (r meat), full fat cheese, eggs, tofu, salmon and processed meat (p meat) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects

Outcomes

Primary Outcome Measures

ROS change
ROS (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
MDA change
MDA (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
IL-6 change
IL-6 (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
hs-CRP change
hs-CRP (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)

Secondary Outcome Measures

estradiol
17-beta-estradiol

Full Information

First Posted
January 26, 2022
Last Updated
May 17, 2022
Sponsor
University of Vienna
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1. Study Identification

Unique Protocol Identification Number
NCT05242978
Brief Title
Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
Official Title
Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation
Study Type
Interventional

2. Study Status

Record Verification Date
May 2022
Overall Recruitment Status
Recruiting
Study Start Date
May 17, 2022 (Actual)
Primary Completion Date
December 31, 2023 (Anticipated)
Study Completion Date
December 31, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Vienna

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative stress parameters in healthy humans following a high intensity physical workout.
Detailed Description
The aim of this research project is to explore the acute impact of specific foods and beverages, which have been shown to be associated with inflammatory processes, mainly in epidemiological studies, on inflammatory and oxidative stress parameters in healthy humans following a high intensity physical workout. The choice of food will mainly be based on the food groups from the Empirical Dietary Inflammatory Index. For that purpose, seventy-two healthy volunteers will be recruited to perform several interventions in order to assess the impact of different nutrient groups or single- foods on oxidative and inflammatory markers. They will be divided into the three groups beverage consumption, plantbased foods and protein sources. The intense physical activity serves to induce a physiological stress response in the body, known to be accompanied by an increase in oxidative and inflammatory stress parameters. The idea is that anti- inflammatory or antioxidant nutrients could potentially attenuate this stress response in dependence on their anti- inflammatory or antioxidant potential. The operability of this concept has already been tested. The main benefit of this approach is to get a deeper insight into short term effects of single foods or beverages on inflammatory and prooxidative processes in humans by using short term intense physical activity as a stress model. One major practical aspect of this approach is to assess dietary components with respect to their pro- or anti-inflammatory-/oxidative stress potential regarding e.g. non-communicable diseases such as type 2 diabetes, coronary heart disease or the metabolic syndrome. Furthermore, it could help to reduce inflammation or oxidative stress during or following high intense physical exercise in order to reduce the stress response during training or competition in order to enhance regeneration and to foster the training gain in sports.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Inflammatory Response, Oxidative Stress, Oxidative Stress Induction

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Model Description
acute consumption of anti- and pro- inflammatory foods and beverages 2 hour prior to intense physical activity
Masking
None (Open Label)
Allocation
Randomized
Enrollment
24 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Impact of GT, coffee, OJ, PGJ, milk, SSB on exercise induced oxidative stress&inflammation
Arm Type
Experimental
Arm Description
single consumption of one cup of green tea (GT), coffee, orange juice (OJ), pomegranate juice (PGJ), milk and sugar sweetened beverage (SSB) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects
Arm Title
Impact of choc, bcc, tomato, walnuts, r&w bread on exercise induced oxidative stress&inflammation
Arm Type
Experimental
Arm Description
single consumption of one proportion of dark chocolate (choc), broccoli (bcc), tomatoes, walnuts, white bread and whole grain bread (r = refined & w = whole grain) 2 hours prior to a 30-min-HIIT resistance circuit exercise in healthy human subjects
Arm Title
Impact of r&p meat, cheese, eggs, tofu, salmon, on exercise induced oxidative stress&inflammation
Arm Type
Experimental
Arm Description
single consumption of one proportion of red meat (r meat), full fat cheese, eggs, tofu, salmon and processed meat (p meat) 2 hours prior to a 30-min- HIIT resistance circuit exercise in healthy human subjects
Intervention Type
Other
Intervention Name(s)
Nutrition
Intervention Description
acute single dose nutrition intervention
Primary Outcome Measure Information:
Title
ROS change
Description
ROS (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
Time Frame
change from baseline to 2.5 hours
Title
MDA change
Description
MDA (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
Time Frame
change from baseline to 2.5 hours
Title
IL-6 change
Description
IL-6 (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
Time Frame
change from baseline to 2.5 hours
Title
hs-CRP change
Description
hs-CRP (change from baseline = after overnight fasting to post exercise (=after 2.5 hours)
Time Frame
change from baseline to 2.5 hours
Secondary Outcome Measure Information:
Title
estradiol
Description
17-beta-estradiol
Time Frame
baseline

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: female human subjects aged 18-40 years no chronical diseases not more than 120 minutes of physical activity per week no regular resistance training within the past 6 months BMI 18.5 - 24.99 kg/m² body fat percentage of at least 20% Exclusion Criteria: contraindications against physical activity anemia fructose or lactose intolerance smoking medications with influence on ROS levels or inflammation allergy or intolerance against intervention food/beverages.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Markus Gassner, MSc
Phone
+436502007014
Email
markus.gassner@univie.ac.at
First Name & Middle Initial & Last Name or Official Title & Degree
Daniel König, Univ Prof
Phone
+43-1-4277-59130
Email
daniel.koenig@univie.ac.at
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Markus Gassner, MSc
Organizational Affiliation
University Assistant
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Daniel König, Univ Prof
Organizational Affiliation
Professor of sports nutrition
Official's Role
Study Director
Facility Information:
Facility Name
University of Vienna
City
Vienna
ZIP/Postal Code
1070
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Markus Gassner, MSc
Phone
+436502007014
Email
markus.gassner@univie.ac.at

12. IPD Sharing Statement

Plan to Share IPD
No

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Acute Impact of Different Foods and Beverages on Exercise Induced Oxidative Stress and Inflammation

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