Clinical Trial of Probiotic Supplementation in Psoriasis Vulgaris
Psoriasis Vulgaris
About this trial
This is an interventional treatment trial for Psoriasis Vulgaris focused on measuring Psoriasis Vulgaris, Psoriasis Area and Severity Index, Interleukin-17, Tumor Necrosis Factor- A, Interleukin-10, Foxp3, Lactobacillus Plantarum IS-10506, Gut Microbiota
Eligibility Criteria
Inclusion Criteria:
Patient Group Inclusion Criteria:
- Psoriasis vulgaris patients with or without treatment
- Mild to moderate degree
- Age 18-70 years old
- Willing to give informed consent
Healthy Control Group Inclusion Criteria:
- Undiagnosed as Psoriasis
- Body mass index (BMI) is matched with the patient group
- Age 18-70 years old
- Willing to give Informed Consent
Exclusion Criteria:
Patient Group Exclusion Criteria:
- Patients on systemic treatment with corticosteroids, methotrexate, cyclosporine, or biologic agents within 3 months prior to sampling
- Take oral antibiotics, laxatives, and proton pump inhibitors (PPI) within 14 days before stool sampling
- Suffering from severe systemic disease, diarrhea
- Pustular psoriasis patients
- Take probiotics within 30 days before stool sampling
Healthy Control Group Exclusion Criteria:
- Patients on systemic treatment with corticosteroids, methotrexate, cyclosporine, or biologic agents within 3 months before stool sampling
- Take oral antibiotics, laxatives, and proton pump inhibitors (PPI) within 14 days before stool sampling
- Suffering from severe systemic disease, diarrhea
Sites / Locations
- Universitas AirlanggaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Placebo Comparator
No Intervention
Treatment Group
Placebo Group
Healty Control Group
In the treatment group, intervention was given in the form of standard therapy and probiotic Lactobacillus plantarum IS 10605 in the amount of 2x1010 CFU for 12 weeks.
In the placebo group, intervention was given in the form of standard therapy and placebo 2x1 sachets for 12 weeks.
Healthy control group was not given any treatment. Stool samples were taken to examine the gut microbiota profile.