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Reparixin as add-on Therapy to Standard of Care to Limit Disease Progression in Adult Patients With COVID-19 and Other Community-Acquired Pneumonia.

Primary Purpose

Infectious Pneumonia, Severe COVID-19

Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Reparixin
Placebo
Sponsored by
Dompé Farmaceutici S.p.A
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Infectious Pneumonia focused on measuring COVID-19, SARS-CoV-2, Infectious pneumonia acquired in the community (CAP)

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Informed consent signed
  2. Male and female ≥18 years old;

  3. Patients hospitalized for clinically suspected CAP, defined as the occurrence of (within 48h from hospital admission):

    1. at least 1 of the following signs/symptoms: dyspnea, cough, purulent sputum, crackles (rales) and/or rhonchi
    2. body temperature > 38°C or <36°C (before or during admission) or leucocytosis (> local ULN)
    3. new/increased pulmonary infiltrate(s) by chest imaging
  4. Need for non-invasive supplemental oxygen (NIAID-OS 5-6; Appendix 14.4.1);
  5. SpO2 <92% at room air, or PaO2/FiO2 (or SpO2/FiO2) <300;

  6. Females of child-bearing potential and with an active sexual life must not wish to get pregnant within 30 days after the end of the study and must be using at least one of the following reliable methods of contraception:

    1. Hormonal contraception, systemic, implantable, transdermal, or injectable contraceptives for at least 2 months before the screening visit until 30 days after the last IMP dose
    2. A non-hormonal intrauterine device [IUD] or female condom with spermicide or contraceptive sponge with spermicide or diaphragm with spermicide or cervical cap with spermicide for at least 2 months before the screening visit until 30 days after the last IMP dose
    3. A male sexual partner who agrees to use a male condom with spermicide
    4. A sterile sexual partner

Female participants of non-child-bearing potential or in post-menopausal status for at least 1 year will be admitted. For all female subjects, with child-bearing potential, pregnancy test result must be negative before first drug intake.

Exclusion Criteria:

  1. Treatment with IMV or ECMO (NIAID-OS 7);
  2. Hepatic dysfunction: ALT or AST > 5 ULN; history of chronic hepatic disease (defined with Child-Pugh score B or C);
  3. Renal dysfunction: estimated glomerular filtration rate (eGFR, MDRD) <50 mL/min/1.73 m2, or need for haemodialysis or hemofiltration;
  4. Current use of >2 immunosuppressive medications or immunosuppression status (AIDS, aplastic anaemia, asplenia, systemic chemotherapy within the past 3 months, neutropenia (ANC < local LLN), solid organ or bone marrow transplant recipients)
  5. Treatment with prohibited medication within 5 half-lives, and inability to stop during treatment period (see section 5.5.2);
  6. Anticipated discharge from the hospital or transfer to another hospital within 72 hours of screening

  7. History of:

    1. intolerance or hypersensitivity to ibuprofen to more than one medication belonging to the class of sulfonamides, such as sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib (hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole does not qualify for exclusion)
    2. lactase deficiency, galactosemia or glucose-galactose malabsorption
    3. gastrointestinal bleeding or perforation due to previous NSAIDs therapy or recurrent peptic ulcer/haemorrhage
    4. allergy to reparixin or any component of the IMP formulation
  8. Active bleeding or bleeding diathesis (excluding menses), prior intracranial haemorrhage
  9. Participation in other interventional clinical trials
  10. Clinical condition not compatible with oral administration of the study drug

  11. Pregnancy:

    1. positive or missing pregnancy test before first drug intake or day 1;
    2. pregnant or lactating women;
    3. women of childbearing potential and fertile men who do not agree to use at least one primary form of contraception for the duration of the study
  12. Current hospital stay >72h
  13. Complicated CAP-associated conditions, such as fungal pulmonary infection, tuberculosis infection, abscess, empyema, significant bilateral pleural effusion, massive pulmonary embolism

Sites / Locations

  • MD Banner University Medical Center /Arizona University
  • Velocity Clinical Research, Chula Vista
  • UC Davis Medical Center - UC Davis Medical Group - DavisRecruiting
  • University of Southern California
  • UCI HealthRecruiting
  • Denver HealthRecruiting
  • Nuvance Health
  • MedStar Health Research Institute-Hyatteville, MarylandRecruiting
  • Research Alliance Inc.
  • University of Florida-Jacksonville
  • University of South Florida
  • Emory Johns Creek Hospital
  • Augusta University Health - Augusta University Medical Center
  • Northwestern University, Feinberg School of MedicineRecruiting
  • Jesse Brown VA Medical Center
  • Insight Hospital & Medical Center Chicago
  • Northshore University HealthSystem
  • Norton Healthcare
  • Tulane Medical Center
  • Ochsner Medical Center
  • Tufts Medical CenterRecruiting
  • Boston Medical Center
  • Beth Israel Deaconess Medical Center
  • Newton-Wellesley HospitalRecruiting
  • NorthStar Anesthesia / Detroit Medical Center
  • MidMichigan Medical Center - MidlandRecruiting
  • William Beaumont Hospital
  • University Hospital - MU HealthcareRecruiting
  • Washington University, School of Medicine
  • Mercy Research St Louis
  • NYU Langone Hospital-BrooklynRecruiting
  • New York University Langone HealthRecruiting
  • NYU Langone Hospital--Long Island
  • Duke University HospitalRecruiting
  • University of Oklahoma Medical Center
  • Oregon Health & Science University (OHSU) - Pulmonary ClinicRecruiting
  • Jefferson University HospitalRecruiting
  • UPMC Presbyterian
  • University of Tennessee Medical Center
  • Baptist Hospitals of Southeast TexasRecruiting
  • Texoma Medical Center
  • University of Utah Hospitals & Clinics
  • University of Virginia Medical Center
  • Virginia Commonwealth University HealthRecruiting
  • Medical College of Wisconsin
  • Hospital Interzonal General de Agudos Dr Jose Penna
  • Hospital Cuenca Alta Nestor Kirchner
  • Hospital Italiano de Buenos Aires
  • Hospital Italiano de La Plata
  • Instituto Medico Platense
  • Clinica Independencia
  • Hospital Aleman
  • Hospital General de Agudos Dr. Ignacio Pirovano
  • Sanatorio Finochietto
  • Sanatorio Parque S.A. Privado
  • Sanatorio de la Cañada
  • Sanatorio Britanico S.A.
  • Sanatorio Parque S.A.
  • Clinica Mayo de Urgencias Medicas Cruz Blanca SRL
  • Hospital Britanico de Buenos Aires
  • Hospital General de Agudos Donacion Francisco Santojanni
  • Hospital General de Agudos Dr. J. M. Ramos Mejia
  • Clinica Adventista Belgrano
  • CEMIC
  • Clinica Chutro
  • Nuevo Hospital San Roque
  • Sanatorio Allende
  • Sanatorio Privado de la Cañada - Cordoba
  • Sanatorio Privado Duarte Quiroz De Clinica Colombo SA
  • Campbelltown Hospital
  • Westmead Hospital
  • Royal Brisbane and Women's Hospital
  • Mater Hospital Brisbane
  • Gold Coast University Hospital
  • Royal Adelaide Hospital
  • Royal Melbourne Hospital
  • Kepler Universitatsklinikum Med Campus III
  • KH der Barmherzigen Brüder Linz
  • Medizinische Universitaet Wien, Medizinische Klinik I, Abteilung für Infektionskrankheiten und TropenmedizinRecruiting
  • Klinik Favoriten (Sozialmedizinisches Zentrum Sued - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital)Recruiting
  • Universitaetsklinikum Freiburg
  • Albeilung für Kardiologie und PneumologieRecruiting
  • Medizinische HochschuleRecruiting
  • Universitaetsklinikum Carl Gustav Carus TU Dresden
  • Universitätsmedizin GöttingenRecruiting
  • Universitaetsklinikum Jena
  • UOC Malattie dell'Apparato Respiratorio, Policlinico di Bari
  • ASST - Ospedale Papa Giovanni XXIII - UOC PneumologiaRecruiting
  • Azienda Ospedaliera Universitaria di Bologna - Ospedale Sant'OrsolaRecruiting
  • Campus Universitario "Salvatore Venuta", Complesso Clinico, Padiglione B, 8° livello, Pneumologia
  • University Of Genoa - Ospedale Policlinico IRCCS San Martino di GenovaRecruiting
  • Fondazione Ca' Granda Policlinico MilanoRecruiting
  • IRCCS Istituto Clinico Humanitas U.O. Medicina D'UrgenzaRecruiting
  • IRCCS Ospedale San Raffaele Centro di Ricerca Anestesia e RianimazioneRecruiting
  • ASST SANTI PAOLO E CARLO Ospedale San Paolo Struttura Complessa Malattie InfettiveRecruiting
  • Università degli Studi di Milano-Ospedale "L.Sacco" Polo Universitario - ASST Fatebenefratelli Sacco
  • ASST Grande Ospedale Metropolitano Niguarda Dipartimento Malattie InfettiveRecruiting
  • A.O.U. Federico II Malattie Infettive del Policlinico Federico IIRecruiting
  • Università della Campania "Luigi Vanvitelli" Dipartimento di Malattie InfettiveRecruiting
  • ASST-Monza Ospedale San Gerardo Malattie InfettiveRecruiting
  • Clinica Pneumologica "L. Vanvitelli" - Osp MonaldiRecruiting
  • Università degli studi di Padova, Unità Malattie Respiratorie
  • AOUP "P.Giaccone" - UOC PneumologiaRecruiting
  • Fondazione IRCCS Policlinico San Matteo - UOC Pneumologia, Dipartimento di Scienze Mediche e Malattie InfettiveRecruiting
  • Struttura semplice di terapia demi-intensiva respiratoria S.C. di pneumologia AO IRCCS Santa Maria NuovaRecruiting
  • Ankara City Hospital
  • Dicle University, Medical Faculty
  • Gaziantep Universitesi Sahinbey Arastirma Ve Uygulama Hastanesi
  • Acibadem Atakent Hospital
  • Ege University Medical Faculty
  • Dokuz Eylul University Faculty of Medicine
  • Kayseri State Hospital
  • Kocaeli Universitesi Tip Fakultesi
  • Inonu Uni.Med.Faculty
  • Karadeniz Tecnical Uni. Med. Fac.

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Reparixin + standard of care

Placebo + standard of care

Arm Description

Reparixin will be administered orally at the dose of 1200 mg (2 x 600 mg tablets) TID (6 tablets daily) for up to 21 days. The three daily doses will be administered maintaining an interval between doses of about 8 hours.

Placebo tablets are identical in appearance to the active formulation. Placebo will be administered with the same treatment schedule.

Outcomes

Primary Outcome Measures

Proportion of patients dead or requiring Invasive Mechanical Ventilation (IMV) or Extracorporeal Membrane Oxygenation (ECMO) by day 28 [NIAID-OS 7].
NIAID-OS = National Institute of Allergy and Infectious Disease - Ordinal Scale

Secondary Outcome Measures

All-cause mortality at day 180
Proportion of patients alive and discharged at day 28
Ventilatory-free days (VFD) at day 28
Number of days from Day 0 to Day 28 when the patient will alive and free of invasive ventilation. In case of multiple periods of IMV during the first 28 days, the total duration of ventilation considered all periods of ventilation during the index admission. Patients who will die within 28 days or will be still on invasive ventilation after 28 days will score zero VFDs18
Occurrence of IMV (or ECMO) by day 28
Length of primary hospital stay
Clinical failure by day 3 and day 7
Clinical failure will be defined as the occurrence of IMV/ECMO or vasopressor, or death
28-day ICU-free days
Days free of IMV/ECMO (number of days with NIAID-OS 1-6) at day 28
Duration of antibiotic therapy (days) at day 28
Hospital free days
Proportion of patients recovered
downward shift from screening of ≤2 points on the NIAID-OS or live discharge from hospital)
Proportion of patients worsening
upward shift from screening of at least >1 point of the NIAID-OS)
PO2/FiO2
All-cause mortality
Hospital re-admission by day 90 and 180
Time to discharge or to a NEWS of ≤ 2 (for 24 hours), whichever occurs first
Change in inflammatory markers (LDH, CRP, ferritin; D-dimer, PCT) and cytokines
Change in quality of life using EuroQol-5-dimensions-5 levels (EQ-5D-5L) questionnaire
The EQ-5D-5L asks patients to indicate whether they have no, slight, moderate, severe, extreme problems on each of five dimensions of health: mobility; self-care; usual activities; pain/discomfort; anxiety/depression.
Duration of IMV and/or ECMO at 90 and 180 days
ICU admission at 90 and 180 days
ICU length of stay at 90 and 180 days
Hospital length of stay at 90 and 180 days
Occurrence of infections at 90 and 180 days

Full Information

First Posted
February 22, 2022
Last Updated
October 4, 2023
Sponsor
Dompé Farmaceutici S.p.A
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1. Study Identification

Unique Protocol Identification Number
NCT05254990
Brief Title
Reparixin as add-on Therapy to Standard of Care to Limit Disease Progression in Adult Patients With COVID-19 and Other Community-Acquired Pneumonia.
Official Title
Reparixin 1200 mg TID as add-on to SoC to Limit Disease Progression in Hospitalised Patients With COVID-19 and Other Community-Acquired Pneumonia. A Multicentre, Randomised, Double-blinded, Placebo-controlled, Phase III Trial (REPAVID-22)
Study Type
Interventional

2. Study Status

Record Verification Date
October 2023
Overall Recruitment Status
Recruiting
Study Start Date
April 6, 2022 (Actual)
Primary Completion Date
September 2024 (Anticipated)
Study Completion Date
October 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Dompé Farmaceutici S.p.A

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Primary objective: - To evaluate the efficacy of oral reparixin versus standard care alone in limiting disease progression in adult patients hospitalised for infectious pneumonia acquired in the community (CAP), including COVID-19. Secondary objectives: - To determine the effect of reparixin on several disease severity/progression measures including recovery, ventilatory free days and mortality. Safety objectives: - To evaluate the safety of oral reparixin versus placebo in the specific clinical setting.
Detailed Description
Multinational, multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase III trial. It will enrol 526 male and female patients >18 years, hospitalised for CAP (including COVID-19), assigned (1:1) to receive either oral reparixin (treatment group) or matched placebo (control group) three times a day (TID) for up to 21 days. Randomisation will be stratified according to disease severity and site. All the patients will receive the standard of care based on their clinical need, including COVID-19 and CAP medications, as per local standard therapy at the trial site and in line with international guidelines. The primary outcome will be evaluated at day 28, secondary will be evaluated from day 3 to day 180. An independent external data monitoring committee (DMC) will oversee the study and evaluate unblinded interim data for efficacy, futility, and safety.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Infectious Pneumonia, Severe COVID-19
Keywords
COVID-19, SARS-CoV-2, Infectious pneumonia acquired in the community (CAP)

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Model Description
male and female patients >18 years, hospitalised for COVID-19, will be assigned (1:1) to receive either oral reparixin (treatment group) or matched placebo (control group) three times a day (TID) for up to 21 days.
Masking
ParticipantCare ProviderInvestigator
Allocation
Randomized
Enrollment
526 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Reparixin + standard of care
Arm Type
Experimental
Arm Description
Reparixin will be administered orally at the dose of 1200 mg (2 x 600 mg tablets) TID (6 tablets daily) for up to 21 days. The three daily doses will be administered maintaining an interval between doses of about 8 hours.
Arm Title
Placebo + standard of care
Arm Type
Placebo Comparator
Arm Description
Placebo tablets are identical in appearance to the active formulation. Placebo will be administered with the same treatment schedule.
Intervention Type
Drug
Intervention Name(s)
Reparixin
Other Intervention Name(s)
Repertaxin L-lysine salt
Intervention Description
Reparixin 600 mg tablets, administered orally at the dose of 1200 mg TID (2 tablets TID) as add-on therapy to standard of care up to 21 days. IMP can be taken with a glass of water (about 250 mL) and a light meal or snack, as it is preferable that reparixin is taken with food. However, if the patient is unable to eat, the study drug may still be administered without concomitant food ingestion.
Intervention Type
Other
Intervention Name(s)
Placebo
Other Intervention Name(s)
Matched placebo
Intervention Description
Administered orally three times a day (TID) as add-on therapy to standard of care up to 21 days. Placebo can be taken with a glass of water (about 250 mL) and a light meal or snack, as it is preferable that placebo is taken with food. However, if the patient is unable to eat, the placebo may still be administered without concomitant food ingestion.
Primary Outcome Measure Information:
Title
Proportion of patients dead or requiring Invasive Mechanical Ventilation (IMV) or Extracorporeal Membrane Oxygenation (ECMO) by day 28 [NIAID-OS 7].
Description
NIAID-OS = National Institute of Allergy and Infectious Disease - Ordinal Scale
Time Frame
Day 28
Secondary Outcome Measure Information:
Title
All-cause mortality at day 180
Time Frame
Day 180
Title
Proportion of patients alive and discharged at day 28
Time Frame
Day 28
Title
Ventilatory-free days (VFD) at day 28
Description
Number of days from Day 0 to Day 28 when the patient will alive and free of invasive ventilation. In case of multiple periods of IMV during the first 28 days, the total duration of ventilation considered all periods of ventilation during the index admission. Patients who will die within 28 days or will be still on invasive ventilation after 28 days will score zero VFDs18
Time Frame
Day 28
Title
Occurrence of IMV (or ECMO) by day 28
Time Frame
Day 28
Title
Length of primary hospital stay
Time Frame
Throughout the trial
Title
Clinical failure by day 3 and day 7
Description
Clinical failure will be defined as the occurrence of IMV/ECMO or vasopressor, or death
Time Frame
day 3 and day 7
Title
28-day ICU-free days
Time Frame
Day 28
Title
Days free of IMV/ECMO (number of days with NIAID-OS 1-6) at day 28
Time Frame
Day 28
Title
Duration of antibiotic therapy (days) at day 28
Time Frame
Day 28
Title
Hospital free days
Time Frame
Day 28
Title
Proportion of patients recovered
Description
downward shift from screening of ≤2 points on the NIAID-OS or live discharge from hospital)
Time Frame
days 3, 7±1, 14±2, 21±2, 28 ±2 or at hospital discharge
Title
Proportion of patients worsening
Description
upward shift from screening of at least >1 point of the NIAID-OS)
Time Frame
days 3, 7±1, 14±2, 21±2, 28 ±2 or at hospital discharge
Title
PO2/FiO2
Time Frame
days 3, 7±1, 14±2, 21±2, 28 ±2 or at hospital discharge
Title
All-cause mortality
Time Frame
Days 28 and 90
Title
Hospital re-admission by day 90 and 180
Time Frame
Days 90 and 180
Title
Time to discharge or to a NEWS of ≤ 2 (for 24 hours), whichever occurs first
Time Frame
Day 28
Title
Change in inflammatory markers (LDH, CRP, ferritin; D-dimer, PCT) and cytokines
Time Frame
Days 3, 7±1, 14±2, 21±2, 28±2 or at hospital discharge]
Title
Change in quality of life using EuroQol-5-dimensions-5 levels (EQ-5D-5L) questionnaire
Description
The EQ-5D-5L asks patients to indicate whether they have no, slight, moderate, severe, extreme problems on each of five dimensions of health: mobility; self-care; usual activities; pain/discomfort; anxiety/depression.
Time Frame
90±7 and 180±14 days
Title
Duration of IMV and/or ECMO at 90 and 180 days
Time Frame
Days 90 and 180
Title
ICU admission at 90 and 180 days
Time Frame
Days 90 and 180
Title
ICU length of stay at 90 and 180 days
Time Frame
Days 90 and 180
Title
Hospital length of stay at 90 and 180 days
Time Frame
Days 90 and 180
Title
Occurrence of infections at 90 and 180 days
Time Frame
Days 90 and 180

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Informed consent signed Male and female ≥18 years old; Patients hospitalized for clinically suspected CAP, defined as the occurrence of (within 48h from hospital admission): at least 1 of the following signs/symptoms: dyspnea, cough, purulent sputum, crackles (rales) and/or rhonchi body temperature > 38°C or <36°C (before or during admission) or leucocytosis (> local ULN) new/increased pulmonary infiltrate(s) by chest imaging Need for non-invasive supplemental oxygen (NIAID-OS 5-6; Appendix 14.4.1); SpO2 <92% at room air, or PaO2/FiO2 (or SpO2/FiO2) <300; Females of child-bearing potential and with an active sexual life must not wish to get pregnant within 30 days after the end of the study and must be using at least one of the following reliable methods of contraception: Hormonal contraception, systemic, implantable, transdermal, or injectable contraceptives for at least 2 months before the screening visit until 30 days after the last IMP dose A non-hormonal intrauterine device [IUD] or female condom with spermicide or contraceptive sponge with spermicide or diaphragm with spermicide or cervical cap with spermicide for at least 2 months before the screening visit until 30 days after the last IMP dose A male sexual partner who agrees to use a male condom with spermicide A sterile sexual partner Female participants of non-child-bearing potential or in post-menopausal status for at least 1 year will be admitted. For all female subjects, with child-bearing potential, pregnancy test result must be negative before first drug intake. Exclusion Criteria: Treatment with IMV or ECMO (NIAID-OS 7); Hepatic dysfunction: ALT or AST > 5 ULN; history of chronic hepatic disease (defined with Child-Pugh score B or C); Renal dysfunction: estimated glomerular filtration rate (eGFR, MDRD) <50 mL/min/1.73 m2, or need for haemodialysis or hemofiltration; Current use of >2 immunosuppressive medications or immunosuppression status (AIDS, aplastic anaemia, asplenia, systemic chemotherapy within the past 3 months, neutropenia (ANC < local LLN), solid organ or bone marrow transplant recipients) Treatment with prohibited medication within 5 half-lives, and inability to stop during treatment period (see section 5.5.2); Anticipated discharge from the hospital or transfer to another hospital within 72 hours of screening History of: intolerance or hypersensitivity to ibuprofen to more than one medication belonging to the class of sulfonamides, such as sulfamethazine, sulfamethoxazole, sulfasalazine, nimesulide or celecoxib (hypersensitivity to sulphanilamide antibiotics alone, e.g. sulfamethoxazole does not qualify for exclusion) lactase deficiency, galactosemia or glucose-galactose malabsorption gastrointestinal bleeding or perforation due to previous NSAIDs therapy or recurrent peptic ulcer/haemorrhage allergy to reparixin or any component of the IMP formulation Active bleeding or bleeding diathesis (excluding menses), prior intracranial haemorrhage Participation in other interventional clinical trials Clinical condition not compatible with oral administration of the study drug Pregnancy: positive or missing pregnancy test before first drug intake or day 1; pregnant or lactating women; women of childbearing potential and fertile men who do not agree to use at least one primary form of contraception for the duration of the study Current hospital stay >72h Complicated CAP-associated conditions, such as fungal pulmonary infection, tuberculosis infection, abscess, empyema, significant bilateral pleural effusion, massive pulmonary embolism
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Maria De Pizzol, BSc
Phone
02 583831
Email
clinops@pec.dompe.it
First Name & Middle Initial & Last Name or Official Title & Degree
Cecilia Conz, BSc
Phone
02 583831
Email
clinops@pec.dompe.it
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Enrico Minnella, MD
Organizational Affiliation
Dompé Farmaceutici
Official's Role
Study Director
Facility Information:
Facility Name
MD Banner University Medical Center /Arizona University
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85719
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christian Bime, MD
Facility Name
Velocity Clinical Research, Chula Vista
City
Chula Vista
State/Province
California
ZIP/Postal Code
91911
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Waters, MD
Facility Name
UC Davis Medical Center - UC Davis Medical Group - Davis
City
Davis
State/Province
California
ZIP/Postal Code
95616
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hien Nguyen, MD
Facility Name
University of Southern California
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luis Huerta, MD
Facility Name
UCI Health
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Timmy Cheng, MD
Facility Name
Denver Health
City
Denver
State/Province
Colorado
ZIP/Postal Code
80204
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ivor Douglas, MD
Facility Name
Nuvance Health
City
Danbury
State/Province
Connecticut
ZIP/Postal Code
06810
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Nee, MD
Facility Name
MedStar Health Research Institute-Hyatteville, Maryland
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Glenn Wortmann, MD
Facility Name
Research Alliance Inc.
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Edison Tan, MD
Facility Name
University of Florida-Jacksonville
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mehdi Mirsaeidi, MD
Facility Name
University of South Florida
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kim Kami, MD
Facility Name
Emory Johns Creek Hospital
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Avanthika Wynn, MD
Facility Name
Augusta University Health - Augusta University Medical Center
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Vazquez, MD
Facility Name
Northwestern University, Feinberg School of Medicine
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard G Wunderink, MD
Facility Name
Jesse Brown VA Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Augusto Alonto, MD
Facility Name
Insight Hospital & Medical Center Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60616
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jaime Torres, MD
Facility Name
Northshore University HealthSystem
City
Evanston
State/Province
Illinois
ZIP/Postal Code
60201
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nirav Shah, MD
Facility Name
Norton Healthcare
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Individual Site Status
Active, not recruiting
Facility Name
Tulane Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joshua Denson, MD
Facility Name
Ochsner Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Hand, MD
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Brian Chow, MD
Facility Name
Boston Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Archana Asundi, MD
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alon Dagan, MD
Facility Name
Newton-Wellesley Hospital
City
Newton
State/Province
Massachusetts
ZIP/Postal Code
02462
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Harry Schrager, MD
Facility Name
NorthStar Anesthesia / Detroit Medical Center
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48201
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wael Saasouh, MD
Facility Name
MidMichigan Medical Center - Midland
City
Midland
State/Province
Michigan
ZIP/Postal Code
48670
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Blamoun, MD
Facility Name
William Beaumont Hospital
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher Carpenter, MD
Facility Name
University Hospital - MU Healthcare
City
Columbia
State/Province
Missouri
ZIP/Postal Code
65212
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dima Dandachi, MD
Facility Name
Washington University, School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stacey House, MD
Facility Name
Mercy Research St Louis
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
George Matuschak, MD
Facility Name
NYU Langone Hospital-Brooklyn
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11220
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ioannis Zacharioudakis, MD
Facility Name
New York University Langone Health
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Kaufman, MD
Facility Name
NYU Langone Hospital--Long Island
City
New York
State/Province
New York
ZIP/Postal Code
11501
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Fleming, MD
Facility Name
Duke University Hospital
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27708
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lana Wahid, MD
Facility Name
University of Oklahoma Medical Center
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hussein Youness, MD
Facility Name
Oregon Health & Science University (OHSU) - Pulmonary Clinic
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Akram Khan, MD
Facility Name
Jefferson University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Baram, MD
Facility Name
UPMC Presbyterian
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Huang, MD
Facility Name
University of Tennessee Medical Center
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37920
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isaac Biney, MD
Facility Name
Baptist Hospitals of Southeast Texas
City
Beaumont
State/Province
Texas
ZIP/Postal Code
77701
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicole Hancock, MD
Facility Name
Texoma Medical Center
City
Denison
State/Province
Texas
ZIP/Postal Code
75020
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aditi Swami, MD
Facility Name
University of Utah Hospitals & Clinics
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84108
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Estelle Harris, MD
Facility Name
University of Virginia Medical Center
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22903
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tarina Parpia, MD
Facility Name
Virginia Commonwealth University Health
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23298
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alan Dow, MD
Facility Name
Medical College of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rahul Nanchal, MD
Facility Name
Hospital Interzonal General de Agudos Dr Jose Penna
City
Bahia Blanca
State/Province
Buenos Aires
ZIP/Postal Code
8001
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Carlos Ditondo, MD
Facility Name
Hospital Cuenca Alta Nestor Kirchner
City
Cañuelas
State/Province
Buenos Aires
ZIP/Postal Code
1814
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Javier Farina, MD
Facility Name
Hospital Italiano de Buenos Aires
City
Ciudad Autonoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
1181
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ventura Simonovich, MD
Facility Name
Hospital Italiano de La Plata
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
1900
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alberto Cremona, MD
Facility Name
Instituto Medico Platense
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
1900
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Fernanda Alzogaray, MD
Facility Name
Clinica Independencia
City
Munro
State/Province
Buenos Aires
ZIP/Postal Code
1605
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pablo Alexis Christian Doreski, MD
Facility Name
Hospital Aleman
City
Buenos Aires
State/Province
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1118
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cristina Freuler, MD
Facility Name
Hospital General de Agudos Dr. Ignacio Pirovano
City
Ciudad de Buenos Aires
State/Province
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1430
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ricardo Augusto Teijeiro, MD
Facility Name
Sanatorio Finochietto
City
Ciudad Autonoma de Buenos Aire
State/Province
Ciudad Autonoma De Buenos Aires
ZIP/Postal Code
1187
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcelo Radisic, MD
Facility Name
Sanatorio Parque S.A. Privado
City
San Vicente
State/Province
Cordoba
ZIP/Postal Code
5006
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hugo Armando Luquez, MD
Facility Name
Sanatorio de la Cañada
City
Villa María
State/Province
Cordoba
ZIP/Postal Code
5900
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dario Conrado Quinodoz, MD
Facility Name
Sanatorio Britanico S.A.
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Esteban Nannini, MD
Facility Name
Sanatorio Parque S.A.
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carolina Subira, MD
Facility Name
Clinica Mayo de Urgencias Medicas Cruz Blanca SRL
City
San Miguel de Tucuman
State/Province
Tucuman
ZIP/Postal Code
4000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Juan Manuel Nunez, MD
Facility Name
Hospital Britanico de Buenos Aires
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1280
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alejandro Salvado, MD
Facility Name
Hospital General de Agudos Donacion Francisco Santojanni
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
1408
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pablo Scapellato, MD
Facility Name
Hospital General de Agudos Dr. J. M. Ramos Mejia
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
1221
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcelo Losso, MD
Facility Name
Clinica Adventista Belgrano
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
1430
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcelo Martin Casas, MD
Facility Name
CEMIC
City
Ciudad Autonoma de Buenos Aire
ZIP/Postal Code
1431
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alex Mario Kostianovsky, MD
Facility Name
Clinica Chutro
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fredy Ferre Pacora, MD
Facility Name
Nuevo Hospital San Roque
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria Leonor Parody, MD
Facility Name
Sanatorio Allende
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fernando Oscar Riera, MD
Facility Name
Sanatorio Privado de la Cañada - Cordoba
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eduardo Manuel Petenian, MD
Facility Name
Sanatorio Privado Duarte Quiroz De Clinica Colombo SA
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hugo Colombo, MD
Facility Name
Campbelltown Hospital
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Belinda Cochrane, MD
Facility Name
Westmead Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jen Kok, MD
Facility Name
Royal Brisbane and Women's Hospital
City
Herston
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Redmond, MD
Facility Name
Mater Hospital Brisbane
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Griffin, MD
Facility Name
Gold Coast University Hospital
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maninder Singh, MD
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mark Plummer, MD
Facility Name
Royal Melbourne Hospital
City
Parkville
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joseph Sasadeusz, MD
Facility Name
Kepler Universitatsklinikum Med Campus III
City
Linz
ZIP/Postal Code
4020
Country
Austria
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helmut Salzer, MD
Facility Name
KH der Barmherzigen Brüder Linz
City
Linz
ZIP/Postal Code
4020
Country
Austria
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Clodi, MD
Facility Name
Medizinische Universitaet Wien, Medizinische Klinik I, Abteilung für Infektionskrankheiten und Tropenmedizin
City
Wien
ZIP/Postal Code
1090
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthias Vossen, MD
Facility Name
Klinik Favoriten (Sozialmedizinisches Zentrum Sued - Kaiser-Franz-Josef-Spital mit Gottfried von Preyer'schem Kinderspital)
City
Wien
ZIP/Postal Code
1100
Country
Austria
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexander Zoufaly, MD
Facility Name
Universitaetsklinikum Freiburg
City
Freiburg
State/Province
Baden Wuerttemberg
ZIP/Postal Code
79106
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Diana Stolz, MD
Facility Name
Albeilung für Kardiologie und Pneumologie
City
Dachau
State/Province
Bavaria
ZIP/Postal Code
85221
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernard Witzenbichler, MD
Facility Name
Medizinische Hochschule
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tobias Welte, MD
Facility Name
Universitaetsklinikum Carl Gustav Carus TU Dresden
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Kolditz, MD
Facility Name
Universitätsmedizin Göttingen
City
Göttingen
State/Province
Südniedersachsen
ZIP/Postal Code
37075
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sabine Blaschke-Steinbrecher, MD
Facility Name
Universitaetsklinikum Jena
City
Jena
State/Province
Thueringen
ZIP/Postal Code
07747
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefan Hagel, MD
Facility Name
UOC Malattie dell'Apparato Respiratorio, Policlinico di Bari
City
Bari
ZIP/Postal Code
70100
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giovanna Elisiana Carpagnano, MD
Facility Name
ASST - Ospedale Papa Giovanni XXIII - UOC Pneumologia
City
Bergamo
ZIP/Postal Code
24127
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fabiano Di Marco, MD
Facility Name
Azienda Ospedaliera Universitaria di Bologna - Ospedale Sant'Orsola
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefano Nava, MD
Facility Name
Campus Universitario "Salvatore Venuta", Complesso Clinico, Padiglione B, 8° livello, Pneumologia
City
Catanzaro
ZIP/Postal Code
88100
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Girolamo Pelaia, MD
Facility Name
University Of Genoa - Ospedale Policlinico IRCCS San Martino di Genova
City
Genova
ZIP/Postal Code
16132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Fulvio Braido, MD
Facility Name
Fondazione Ca' Granda Policlinico Milano
City
Milano
ZIP/Postal Code
20122
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Blasi, MD
Facility Name
IRCCS Istituto Clinico Humanitas U.O. Medicina D'Urgenza
City
Milan
ZIP/Postal Code
20089
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antonio Voza, MD
Facility Name
IRCCS Ospedale San Raffaele Centro di Ricerca Anestesia e Rianimazione
City
Milan
ZIP/Postal Code
20132
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giovanni Landoni, Prof, MD
Facility Name
ASST SANTI PAOLO E CARLO Ospedale San Paolo Struttura Complessa Malattie Infettive
City
Milan
ZIP/Postal Code
20142
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Giulia Carla Marchetti, MD
Facility Name
Università degli Studi di Milano-Ospedale "L.Sacco" Polo Universitario - ASST Fatebenefratelli Sacco
City
Milan
ZIP/Postal Code
20157
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pierachille Santus, MD
Facility Name
ASST Grande Ospedale Metropolitano Niguarda Dipartimento Malattie Infettive
City
Milan
ZIP/Postal Code
20162
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Massimo Puoti, MD
Facility Name
A.O.U. Federico II Malattie Infettive del Policlinico Federico II
City
Milan
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ivan Gentile, MD
Facility Name
Università della Campania "Luigi Vanvitelli" Dipartimento di Malattie Infettive
City
Milan
ZIP/Postal Code
80133
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicola Coppola, MD
Facility Name
ASST-Monza Ospedale San Gerardo Malattie Infettive
City
Monza
ZIP/Postal Code
20900
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paolo Bonfanti, MD
Facility Name
Clinica Pneumologica "L. Vanvitelli" - Osp Monaldi
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrea Bianco, MD
Facility Name
Università degli studi di Padova, Unità Malattie Respiratorie
City
Padova
ZIP/Postal Code
35128
Country
Italy
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paolo Spagnolo, MD
Facility Name
AOUP "P.Giaccone" - UOC Pneumologia
City
Palermo
ZIP/Postal Code
90127
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicola Scichilone, MD
Facility Name
Fondazione IRCCS Policlinico San Matteo - UOC Pneumologia, Dipartimento di Scienze Mediche e Malattie Infettive
City
Pavia
ZIP/Postal Code
27100
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Angelo Corsico, MD
Facility Name
Struttura semplice di terapia demi-intensiva respiratoria S.C. di pneumologia AO IRCCS Santa Maria Nuova
City
Reggio Emilia
ZIP/Postal Code
42123
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicola Facciolongo, MD
Facility Name
Ankara City Hospital
City
Ankara
ZIP/Postal Code
06800
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hatice Rahmet Guner, MD
Facility Name
Dicle University, Medical Faculty
City
Diyarbakır
ZIP/Postal Code
21280
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Celen Mustafa Kemal, MD
Facility Name
Gaziantep Universitesi Sahinbey Arastirma Ve Uygulama Hastanesi
City
Gaziantep
ZIP/Postal Code
27310
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ayse Ozlem Mete, MD
Facility Name
Acibadem Atakent Hospital
City
Istanbul
ZIP/Postal Code
34303
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Iftihar Koksal, MD
Facility Name
Ege University Medical Faculty
City
İzmir
ZIP/Postal Code
35100
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Husnu Pullukcu, MD
Facility Name
Dokuz Eylul University Faculty of Medicine
City
İzmir
ZIP/Postal Code
35340
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sukran Kose, MD
Facility Name
Kayseri State Hospital
City
Kayseri
ZIP/Postal Code
38039
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ilhami Celik, MD
Facility Name
Kocaeli Universitesi Tip Fakultesi
City
Kocaeli
ZIP/Postal Code
41380
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sila Cetin Akhan, MD
Facility Name
Inonu Uni.Med.Faculty
City
Malatya
ZIP/Postal Code
44100
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yasar Bayindir, MD
Facility Name
Karadeniz Tecnical Uni. Med. Fac.
City
Trabzon
ZIP/Postal Code
61080
Country
Turkey
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Firdevs Aksoy, MD

12. IPD Sharing Statement

Learn more about this trial

Reparixin as add-on Therapy to Standard of Care to Limit Disease Progression in Adult Patients With COVID-19 and Other Community-Acquired Pneumonia.

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