Lactobacillus-containing Cultured Milk Drink Alleviates Depression Score Among Adults With Irritable Bowel Syndrome
Irritable Bowel Syndrome With Subthreshold Depression
About this trial
This is an interventional treatment trial for Irritable Bowel Syndrome With Subthreshold Depression focused on measuring irritable bowel syndrome, subthreshold depression, probiotics, IBS, subclinical depression
Eligibility Criteria
Inclusion Criteria:
- Aged 18 to 65 years old,
- Meet ROME IV criteria for irritable bowel syndrome,
- Consented to participate in the study.
Exclusion Criteria:
- Lactose intolerance,
- Gastrointestinal disorders such as inflammatory bowel diseases, liver diseases, pancreatic diseases or malignancies,
- Any neurological diseases or malignancies,
- Pregnant and lactating mothers,
- Any metabolic diseases such as hypertension, hypercholesterolaemia, diabetes mellitus, hyper- and hypothyroidism.
- Known psychiatric diagnoses or/and consume psychotropic drugs,
- Ongoing electroconvulsive therapy (ECT),
- Consumption of antibiotics, probiotics, prebiotics, symbiotics products, laxatives, antispasmodics, and/or anticholinergics who refuse to consent for participation.
Sites / Locations
- Universiti Kebangsaan MalaysiaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Placebo Comparator
Active Comparator
Placebo Comparator
Experimental
Irritable bowel syndrome with normal mood receiving placebo
Irritable bowel syndrome with normal mood receiving probiotics
Irritable bowel syndrome with subthreshold depression receiving placebo
Irritable bowel syndrome with subthreshold depression receiving probiotics
A total of 35 patients diagnosed with IBS as per Rome IV criteria who scored CESD-R less than 16 will be supplemented with placebo drinks.
A total of 35 patients diagnosed with IBS as per Rome IV criteria who scored CESD-R less than 16 will be given lactobacillus-containing cultured milk drinks.
A total of 35 patients diagnosed with IBS as per Rome IV criteria who scored CESD-R of 16 or above will be supplemented with placebo drinks.
A total of 35 patients diagnosed with IBS as per Rome IV criteria who scored CESD-R of 16 or above will be given lactobacillus-containing cultured milk drinks.