Independent Effects of High-cholesterol (High-egg) and High-saturated Fat Diets on LDL-cholesterol
Hypercholesterolemia, Hyperlipidemias, Physical Inactivity
About this trial
This is an interventional basic science trial for Hypercholesterolemia focused on measuring Cholesterol, Eggs, Saturated Fat, Low density lipoprotein cholesterol, lutein, physical activity
Eligibility Criteria
Inclusion Criteria:
- Male or female, aged 18 - 60 years
- Blood LDL-C <3.5 mmol/L (measured at screening using an automated analyser (Cholestech LDX System).
- Non-smoker (or other nicotine products) (minimum 6 months).
Exclusion Criteria:
- Have diagnosed cardiovascular disease (including uncontrolled high blood pressure) or a chronic disease, including Type-1 or -2 diabetes, kidney or liver disease, gastrointestinal disorders requiring medical nutrition therapy (e.g., Crohn's disease, irritable bowel, coeliac disease) or any other condition that may have an impact on study outcomes.
- Have allergies or strong aversion to eggs or other components of the test foods (diets are not suitable for vegetarians).
- Consume more than 5 eggs per week in the month prior to beginning the trial.
- Participant has a recent history (within 12 months) or strong potential for alcohol abuse. Defined as >14 standard drinks per week.
- Have changed medication or supplementation that might affect study outcomes in the last 3 months.
- Take vitamin, mineral, herbal supplementation, or medications that may have an impact on study outcomes.
- Are already involved in another research project within 30 days of commencement of the present study that in the opinion of the investigators will be unsuitable for this study.
- Are pregnant or breastfeeding.
- Show unwillingness to be randomized to either experimental group.
- Failure to satisfy the investigator regarding suitability to participate for any other reason.
- Are unwilling or unable to provide written informed consent.
Sites / Locations
- University of South Australia Clinical Trial FacilityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
Egg Diet
Egg-free Diet
Control Diet
Egg diet, contains 2 eggs per day and limits saturated fat to 6% of energy intake. Cholesterol intake is 600mg/day. Protein and carbohydrate levels will be maintained at 20% and 40% of energy intake, respectively. This diet will be followed for 5 weeks.
Egg-free diet, limits cholesterol to 300 mg/day (no eggs) with saturated fat intake at 12% of energy intake. Protein and carbohydrate levels will be maintained at 25% and 40% of energy intake, respectively. This diet will be followed for 5 weeks.
Comparator diet based on the average Australian diet, limited to 1 egg per week, with saturated fat intake at 12% of energy intake. Cholesterol intake is 600 mg/day. Protein and carbohydrate levels will be maintained at 25% and 40% of energy intake, respectively. This diet will be followed for 5 weeks.