Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
Keratitis, Ulcerative, Antibiotic Resistance, Microbial, Photothermal Therapy
About this trial
This is an interventional treatment trial for Keratitis, Ulcerative focused on measuring Photothermal Therapy, Keratitis, Ulcerative, Antibiotic Resistance, Microbial
Eligibility Criteria
Inclusion Criteria:
- The monocular cases of severe infectious keratitis admitted to our center were diagnosed as fungal keratitis according to their medical history, physical signs and surface secretions smear examination of corneal ulcer lesions (severe was defined as subjects with visual acuity < 0.15, deep stromal infiltration or involvement diameter >2mm, with extensive infiltration around or with extensive suppuration)
- After more than 2 weeks of active treatment with antibiotics, there was no effect
- The researchers communicated with the subjects in detail, and the subjects cooperated well and they voluntarily participated and signed informed consent
Exclusion Criteria:
- Allergic to the drug in this test.
- Pregnant and lactating women.
- The medical history suggests serious heart, lung, liver, kidney dysfunction.
- Patients with other factors that would affect the results of this result.
- No signed informed consent.
Sites / Locations
- Second Affiliated Hospital of Zhejiang University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
Nanogel photothermal therapy
Voriconazole eye drops
Normal saline
After the subjects were enrolled in the study, the eyes were coated with Au-Ag-Cu2O nano-gel once (the concentration was 26.4μg/mL, the dosage was suitable to cover the ulcer surface evenly, and the dosage was recorded). Combined with mdl-n-808-10w near-infrared laser (China changchun new industry photoelectric technology) combined with photothermal therapy (laser wavelength 808 nm, power 1.5W/cm2, temperature controlled at 40℃, lasting 10min)
Voliconazole eye drops (once in half an hour) were also used in the control group.
Normal saline eye drops (once in half an hour) were also used in the control group.