Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?
Schizophrenia, Bipolar Disorder
About this trial
This is an interventional basic science trial for Schizophrenia focused on measuring ketogenic diet, metabolic syndrome, fMRI, functional connectivity
Eligibility Criteria
Inclusion Criteria:
- Male or female ages 18-65 years old
- SCID-5 Schizophrenia or schizoaffective disorder stable on 2nd generation anti-psychotic (SZ) or bipolar disorder (BD)
- Willing to adhere to 4 wk. KETO diet
- Speak, read, comprehend English
- Access to internet
- Willing and able to heat up KETO meals
Exclusion Criteria:
- Current Cancer diagnosis
- Other SCID-5 Axis 1 disorder
- Pregnancy, breastfeeding, or planned pregnancy
- Current diagnosis of type 1 Diabetes Mellitus
- Glucose-lowering drugs (other than metformin) or weight loss pills
- History of gastric bypass surgery or any weight loss surgery
- >10% weight fluctuation in past 2 years
Sites / Locations
- San Francisco VA Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Ketogenic Diet
Diet as usual
The ketogenic diet is a normo-caloric diet composed of high-fat (70%), low-carbohydrate (10%), and adequate protein (20%) that induces fasting-like effects and the production of ketone bodies. Metabolic Meals will be delivered to KETO subjects' homes via courier, consisting of 3 meals a day plus snacks, targeting 70% fat, 20% protein, 10% carbohydrates.
The Diet As Usual (DAU) participants will be asked to maintain their current dietary habits and will be discouraged from starting new diets during the 4-week study.