The Effects of Repeated Exposure to Antiseptics During COVID-19 Pandemic on Skin Parameters
Irritation/Irritant, ICD - Irritant Contact Dermatitis, Antiseptic
About this trial
This is an interventional treatment trial for Irritation/Irritant
Eligibility Criteria
Inclusion Criteria:
- young, healthy volunteers who gave written informed consent
Exclusion Criteria:
- skin disease, skin damage on measurement sites
- use of corticosteroids, antihistamines and immunomodulators a month prior the inclusion and during the trial
- use of emollients three days prior the inclusion in the trial
- non-adherence to the trial protocol
- pregnancy and lactation
- skin cancer
- immunosuppression
- exposure to artificial UV radiation
Sites / Locations
- University of Split School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
No Intervention
No Intervention
No Intervention
Repated exposure to antiseptic and treatment
Sham irritation and treatment
No irritation and treatment
Repated exposure to antiseptic and no treatment
Sham irritation and no treatment
No irritation and no treatment
Repeated exposure of forearm skin to antiseptic (once daily for 2 hours under occlusion, during three weeks) Emollient cream treatment 3 times a day
Repeated exposure of forearm skin to deionized water (once daily for 2 hours under occlusion, during three weeks) Emollient cream treatment 3 times a day
Intact skin on forearms Emollient cream treatment 3 times a day
Repeated exposure of forearm skin to antiseptic (once daily for 2 hours under occlusion, during three weeks) No emollient cream treatment
Repeated exposure of forearm skin to deionized water (once daily for 2 hours under occlusion, during three weeks) No emollient cream treatment
Intact skin on forearms No emollient cream treatment