Effects of IMT on Functional Capacity in Patients With Chronic COVID After Hospital Discharge (InsCOVID)
COVID-19 Pneumonia
About this trial
This is an interventional treatment trial for COVID-19 Pneumonia
Eligibility Criteria
Inclusion Criteria:
- Symptomatic adult patients >18 years old with the previous admission due to SARS-CoV-2 pneumonia
- > 3-month after discharge
- The patient provides informed consent
Exclusion Criteria:
- Inability to perform a maximal baseline exercise test
- Structural heart disease, valve heart disease, or diastolic dysfunction estimated by 2-dimensional echocardiography
- Patients with previous ischemic heart disease, heart failure, myocardiopathy, or myocarditis
- Effort angina or signs of ischemia during CPET
- Significant primary pulmonary disease, including a history of pulmonary arterial hypertension, chronic thromboembolic pulmonary disease, or chronic obstructive pulmonary disease
(g) Treatment with digitalis, calcium channel blockers, β-blocker or ivabradine (h) Patients with chronic kidney disease (glomerular filtration rate <60mL/min/1.73m2) (i) Patients with pacemakers or previous history of atrial fibrillation; (j) patients with autoimmune, inflammatory or active neoplastic disease k) Anemia (l) Pregnancy.
Sites / Locations
- INCLIVA
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Control arm
Inspiratory muscle training
Patients allocated to the control arm will not receive inspiratory muscle training. They will be checked each week by a physiotherapist responsible for training intervention who will measure their maximal inspiratory pressure
Patients allocated to the IMT arm will be instructed to train at home twice daily, for 20 minutes each session, using a Threshold inspiratory muscle trainer (Respironics Inc., Parsippany, NJ). They will be instructed by a physiotherapist responsible for training intervention and educated to maintain diaphragmatic breathing during the training period. The subjects will start breathing at a resistance equal to 25% to 30% of their maximal inspiratory mouth pressure (MIP) for 1 week. The respiratory therapist will examine the patients at weekly intervals by checking the diary card and measuring the MIP each time. The resistance will be modified each session according to the 25% to 30% of their MIP measured.