The Clinical Study of Dexmedetomidine and Esketamine Combined Infusion Undergoing Modified Radical Mastectomy
Dexmedetomidine, Esketamine, Postoperative Pain and Recovery Quality
About this trial
This is an interventional treatment trial for Dexmedetomidine, Esketamine, Postoperative Pain and Recovery Quality focused on measuring Dexmedetomidine, esketamine, pain, recovery quality
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅱ
- Scheduled for elective modified radical mastectomy
Exclusion Criteria:
- Severe respiratory disease
- Renal or hepatic insufficiency
- History of preoperative psychiatric
- Preoperative bradycardia
- Preoperative atrioventricular block
- Preoperative hypertension
- BMI>30
Sites / Locations
- Department of Anqing Hospital Anesthesiology
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Dexmedetomidine infusion on recovey quality with radical mastectomy
Co-administration dexmedetomidine and low-dose esketamine on recovey quality with radical mastectomy
Combined dexmedetomidine and high-dose esketamine on recovey quality with radical mastectomy
Drug: Dexmedetomidine infusion Patients received dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until 20 min before the end of operation
Drug: Dexmedetomidine and low-dose eskeamine combined infusion Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg) and esketamine (0.5 mg/kg)over 10 min before the induction of anesthesia, and then dexmedetomidine were infused at a rate of 0.4 µg/kg/h and 2 µg/kg/min until 20 min before the end of operation, respectively.
Drug: Dexmedetomidine and high-dose eskeamine combined infusion Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg) and esketamine (0.5 mg/kg)over 10 min before the induction of anesthesia, and then dexmedetomidine were infused at a rate of 0.4 µg/kg/h and 4 µg/kg/min until 20 min before the end of operation, respectively.