search
Back to results

From the Emergency Department Directly to Ablation of Atrial Fibrillation Study (EMERGE Cryo)

Primary Purpose

Atrial Fibrillation (AF)

Status
Recruiting
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
Ablation of atrial fibrillation (AF)
Sponsored by
Asklepios proresearch
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Atrial Fibrillation (AF) focused on measuring Ablation

Eligibility Criteria

18 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Documented, paroxysmal or persistent AF (longest AF episode < 6-month duration). Any ECG documentation of AF (12 lead ECG, Holter ECG or mobile ECG monitoring) needs to be presented.
  • Recent-onset AF (≤ 1 year prior to enrolment)
  • Presenting at the emergency department or outpatient clinic within the last 2 weeks because of AF, including patients with spontaneous conversion in sinus rhythm (with prior AF documentation)
  • Age ≥ 18 years
  • Subject is able and willing to give informed consent

Exclusion Criteria

  • Pers. AF > 6 Mon (one episode)
  • LA-Diameter > 60mm
  • Severe mitral stenosis or regurgitation, prior mitral valve reconstruction or replacement
  • Any previous left atrial ablation
  • Ongoing continuous AAD therapy with Amiodarone at baseline
  • History of failed continuous AAD therapy with > 1 agent. Exceptions are Beta blocker, Verapamil or "pill in the pocket"-therapy.
  • Any condition or disease, which is contraindication for AF ablation, up to the assessment of the investigator
  • Any condition or disease, which is a contraindication for antiarrhythmic drug treatment, up to the assessment of the investigator
  • Known intra-cardiac thrombus formation under continuous oral anticoagulation (defined as intake >4 weeks)
  • Any contraindication for oral anticoagulation
  • Any untreated or uncontrolled hyperthyroidism or other reversible causes for AF like alcoholism
  • Pregnant or breastfeeding woman or woman of childbearing potential not on adequate birth control
  • Active systemic infection
  • Co-Existence of non PV-dependent atrial Tachycardia

Sites / Locations

  • Asklepios Hospital St. GeorgRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

No Intervention

Arm Label

Group1: Cryo-AF-Ablation

Group 2: Usual care

Arm Description

Patients randomized in the Cryo-AF-Ablation group should receive the cryo AF ablation within 21 days from baseline.

Patients randomized in the usual care group should start or maintain on AAD therapy within 21 days from baseline, based on decision of the investigator according to current ESC Guidelines.

Outcomes

Primary Outcome Measures

Freedom from any atrial tachyarrhythmia
Freedom from any atrial tachyarrhythmia, including atrial fibrillation (AF), atrial flutter and atrial tachycardias (>30 s) through 3 to 12 months follow-up on ILR monitoring or any 12 lead ECG on visits, ECG Holter monitoring, or on symptom driven event monitoring

Secondary Outcome Measures

AF burden (1)
AF burden between 3 to 12 months after randomization. AF burden is defined as overall percentage of AF during the observed time
AF burden (2)
AF burden between 0 to 3, 3 to 6 and 6 to 12 months after randomization
Freedom from atrial fibrillation
Freedom from atrial fibrillation (AF) (>30 s)
Freedom from atrial tachycardia and atrial flutter
Freedom from atrial tachycardia and atrial flutter (AFl)
symptomatic versus asymptomatic atrial tachyarrhythmia
Analysis of amount of symptomatic versus asymptomatic atrial tachyarrhythmia recurrences
Re-hospitalization rate
Re-hospitalization rate due to cardiovascular disease (AF, worsening of heart failure, cardiovascular disease)
Progression of heart failure
Progression of heart failure defined as trend in LV-EF and trend in BNP
Quality of life (AFEQT and EQ-5D-5L)
Improvement of quality of life at 12 months compared to baseline (AFEQT and EQ-5D-5L Questionnaire)
Safety / Complications
Safety / Complications

Full Information

First Posted
March 4, 2022
Last Updated
March 23, 2022
Sponsor
Asklepios proresearch
Collaborators
Atrial Fibrillation Network, Medtronic Bakken Research
search

1. Study Identification

Unique Protocol Identification Number
NCT05294445
Brief Title
From the Emergency Department Directly to Ablation of Atrial Fibrillation Study
Acronym
EMERGE Cryo
Official Title
From the Emergency Department Directly to Ablation of Atrial Fibrillation - Study - The "EMERGE Cryo Study"
Study Type
Interventional

2. Study Status

Record Verification Date
March 2022
Overall Recruitment Status
Recruiting
Study Start Date
December 15, 2021 (Actual)
Primary Completion Date
December 14, 2026 (Anticipated)
Study Completion Date
December 14, 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Asklepios proresearch
Collaborators
Atrial Fibrillation Network, Medtronic Bakken Research

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The study is a prospective, two-arm, randomized, open-label, blinded endpoint, multi-center study to investigate the impact of first line ablation in patients presenting at the emergency room with recent-onset paroxysmal or persistent atrial fibrillation.
Detailed Description
As stated in the current guidelines, the prevalence of AF tripled over the last 30 years and further progress is expected. AF is associated with increased mortality and morbidity. Approximately 70% of the patients who are hospitalized for AF are admitted through the emergency department. The steady increase of AF-related visits at the emergency departments therefore lead to a high number of hospitalizations. The direct costs of AF already amount to approximately 1% of total healthcare spending, driven by AF-related complications (e.g. stroke) and treatment costs (e.g. hospitalizations). These costs will increase dramatically unless AF is prevented and treated in a timely and effective manner. Catheter ablation therapy has been proven to be safe and effective for the treatment of paroxysmal and persistent AF and is now standard in AF therapy. Several trials have shown that catheter ablation of AF is superior to antiarrhythmic drug therapy. As evidenced by the FIRE & ICE trial, cryoballoon ablation is non-inferior to the former goldstandard of radiofrequency current (RFC) energy. Importantly, it has been reported that cryoballoon ablation was associated with a reduction in resource use and costs as compared to RFC ablation of AF. These cost savings persisted over multiple healthcare systems. However, data on the optimal timing of AF ablation is scarce. While there is evidence that catheter ablation is highly efficient in delaying progression from paroxysmal to persistent AF, there are only few trials evaluating a strategy of early treatment of AF, regarding the patients' medical history (CRYO-FIRST, EARLY-AF). Another trial investigated the utilization of a multidisciplinary AF treatment pathway in patients presenting to the emergency department, which resulted in reduction of admission rate and hospital stays but did not include catheter ablation of AF. However, there is no scientific evidence on a strategy of early treatment of atrial fibrillation comparing anti-arrhythmic drug therapy to catheter ablation in the large number of patients presenting to the emergency departments. A well-known limitation of many trials investigating catheter ablation of AF, can be found during the trials follow up after ablation, as detection of AF recurrences can be challenging. The sensitivity of detecting asymptomatic episodes with intermittent 24-hours ECG-monitoring is low. The Heart Rhythm Society and the European Heart Rhythm Society encourage continuous arrhythmia monitoring due to the greater sensitivity in detecting symptomatic and asymptomatic AF recurrences but also when assessing the overall AF burden. Additionally, in an era of digital revolution, the AFNET incorporated the use of wearables, smartphones, hand held-devices and health-related apps to new approaches of AF management. To evaluate the efficacy and safety of an early rhythm control treatment of AF by catheter ablation with the cryoballoon with particular respect to arrhythmia recurrence, rehospitalisation, heart failure and health care costs in patients presenting to the emergency department due to AF, a prospective randomized study is necessary.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Atrial Fibrillation (AF)
Keywords
Ablation

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
prospective, two-arm, randomized, open-label, blinded endpoint, multi-center study
Masking
Outcomes Assessor
Masking Description
Additionally to ILR interrogation on each site, the ILR data will be reviewed by blinded core lab investigators. All observed primary endpoints and outcome parameters will be presented to ERC.
Allocation
Randomized
Enrollment
350 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Group1: Cryo-AF-Ablation
Arm Type
Active Comparator
Arm Description
Patients randomized in the Cryo-AF-Ablation group should receive the cryo AF ablation within 21 days from baseline.
Arm Title
Group 2: Usual care
Arm Type
No Intervention
Arm Description
Patients randomized in the usual care group should start or maintain on AAD therapy within 21 days from baseline, based on decision of the investigator according to current ESC Guidelines.
Intervention Type
Procedure
Intervention Name(s)
Ablation of atrial fibrillation (AF)
Intervention Description
Cryo-AF-ablation of pulmonary vein (pulmonary vein isolation = PVI)
Primary Outcome Measure Information:
Title
Freedom from any atrial tachyarrhythmia
Description
Freedom from any atrial tachyarrhythmia, including atrial fibrillation (AF), atrial flutter and atrial tachycardias (>30 s) through 3 to 12 months follow-up on ILR monitoring or any 12 lead ECG on visits, ECG Holter monitoring, or on symptom driven event monitoring
Time Frame
within 3 to 12 months follow-up
Secondary Outcome Measure Information:
Title
AF burden (1)
Description
AF burden between 3 to 12 months after randomization. AF burden is defined as overall percentage of AF during the observed time
Time Frame
within 3 to 12 months follow up
Title
AF burden (2)
Description
AF burden between 0 to 3, 3 to 6 and 6 to 12 months after randomization
Time Frame
within 0 to 12 months follow up
Title
Freedom from atrial fibrillation
Description
Freedom from atrial fibrillation (AF) (>30 s)
Time Frame
within 3 to 12 months follow up
Title
Freedom from atrial tachycardia and atrial flutter
Description
Freedom from atrial tachycardia and atrial flutter (AFl)
Time Frame
within 3 to 12 months follow up
Title
symptomatic versus asymptomatic atrial tachyarrhythmia
Description
Analysis of amount of symptomatic versus asymptomatic atrial tachyarrhythmia recurrences
Time Frame
within 3 to 12 months follow up
Title
Re-hospitalization rate
Description
Re-hospitalization rate due to cardiovascular disease (AF, worsening of heart failure, cardiovascular disease)
Time Frame
up to 12 months follow up
Title
Progression of heart failure
Description
Progression of heart failure defined as trend in LV-EF and trend in BNP
Time Frame
up to 12 months follow up
Title
Quality of life (AFEQT and EQ-5D-5L)
Description
Improvement of quality of life at 12 months compared to baseline (AFEQT and EQ-5D-5L Questionnaire)
Time Frame
within 0 to 12 months follow up
Title
Safety / Complications
Description
Safety / Complications
Time Frame
within 0 to 12 months follow up

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Documented, paroxysmal or persistent AF (longest AF episode < 6-month duration). Any ECG documentation of AF (12 lead ECG, Holter ECG or mobile ECG monitoring) needs to be presented. Recent-onset AF (≤ 1 year prior to enrolment) Presenting at the emergency department or outpatient clinic within the last 2 weeks because of AF, including patients with spontaneous conversion in sinus rhythm (with prior AF documentation) Age ≥ 18 years Subject is able and willing to give informed consent Exclusion Criteria Pers. AF > 6 Mon (one episode) LA-Diameter > 60mm Severe mitral stenosis or regurgitation, prior mitral valve reconstruction or replacement Any previous left atrial ablation Ongoing continuous AAD therapy with Amiodarone at baseline History of failed continuous AAD therapy with > 1 agent. Exceptions are Beta blocker, Verapamil or "pill in the pocket"-therapy. Any condition or disease, which is contraindication for AF ablation, up to the assessment of the investigator Any condition or disease, which is a contraindication for antiarrhythmic drug treatment, up to the assessment of the investigator Known intra-cardiac thrombus formation under continuous oral anticoagulation (defined as intake >4 weeks) Any contraindication for oral anticoagulation Any untreated or uncontrolled hyperthyroidism or other reversible causes for AF like alcoholism Pregnant or breastfeeding woman or woman of childbearing potential not on adequate birth control Active systemic infection Co-Existence of non PV-dependent atrial Tachycardia
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Nele Gessler, MD, PhD
Phone
+49-40-181885-3069
Email
n.gessler@asklepios.com
First Name & Middle Initial & Last Name or Official Title & Degree
Melanie Gunawardene, MD, PhD
Phone
+49-40-181885-5412
Email
m.gunawardene@asklepios.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Stephan Willems, MD, PhD
Organizational Affiliation
Asklepios Hospital St. Georg, Hamburg, Germany
Official's Role
Principal Investigator
Facility Information:
Facility Name
Asklepios Hospital St. Georg
City
Hamburg
ZIP/Postal Code
20099
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephan Willems, MD, PhD
Email
s.willems@asklepios.com

12. IPD Sharing Statement

Citations:
PubMed Identifier
30874766
Citation
Packer DL, Mark DB, Robb RA, Monahan KH, Bahnson TD, Poole JE, Noseworthy PA, Rosenberg YD, Jeffries N, Mitchell LB, Flaker GC, Pokushalov E, Romanov A, Bunch TJ, Noelker G, Ardashev A, Revishvili A, Wilber DJ, Cappato R, Kuck KH, Hindricks G, Davies DW, Kowey PR, Naccarelli GV, Reiffel JA, Piccini JP, Silverstein AP, Al-Khalidi HR, Lee KL; CABANA Investigators. Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial. JAMA. 2019 Apr 2;321(13):1261-1274. doi: 10.1001/jama.2019.0693.
Results Reference
result
PubMed Identifier
31431051
Citation
Asad ZUA, Yousif A, Khan MS, Al-Khatib SM, Stavrakis S. Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Circ Arrhythm Electrophysiol. 2019 Sep;12(9):e007414. doi: 10.1161/CIRCEP.119.007414. Epub 2019 Aug 21.
Results Reference
result
PubMed Identifier
27567408
Citation
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P; ESC Scientific Document Group. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016 Oct 7;37(38):2893-2962. doi: 10.1093/eurheartj/ehw210. Epub 2016 Aug 27. No abstract available.
Results Reference
result
PubMed Identifier
27742775
Citation
Gunawardene MA, Hoffmann BA, Schaeffer B, Chung DU, Moser J, Akbulak RO, Jularic M, Eickholt C, Nuehrich J, Meyer C, Willems S. Influence of energy source on early atrial fibrillation recurrences: a comparison of cryoballoon vs. radiofrequency current energy ablation with the endpoint of unexcitability in pulmonary vein isolation. Europace. 2018 Jan 1;20(1):43-49. doi: 10.1093/europace/euw307.
Results Reference
result
PubMed Identifier
32632547
Citation
Gunawardene MA, Hartmann J, Jularic M, Eickholt C, Gessler N, Willems S. [Therapeutic management of nonvalvular atrial fibrillation]. Herz. 2020 Sep;45(6):603-616. doi: 10.1007/s00059-020-04960-w. German.
Results Reference
result
PubMed Identifier
32107811
Citation
Gunawardene MA, Eickholt C, Akbulak RO, Jularic M, Klatt N, Hartmann J, Schluter M, Meyer C, Willems S, Schaeffer B. Ultra-high-density mapping of conduction gaps and atrial tachycardias: Distinctive patterns following pulmonary vein isolation with cryoballoon or contact-force-guided radiofrequency current. J Cardiovasc Electrophysiol. 2020 May;31(5):1051-1061. doi: 10.1111/jce.14413. Epub 2020 Mar 9.
Results Reference
result
PubMed Identifier
24134539
Citation
Schmidt M, Dorwarth U, Andresen D, Brachmann J, Kuck KH, Kuniss M, Lewalter T, Spitzer S, Willems S, Senges J, Junger C, Hoffmann E. Cryoballoon versus RF ablation in paroxysmal atrial fibrillation: results from the German Ablation Registry. J Cardiovasc Electrophysiol. 2014 Jan;25(1):1-7. doi: 10.1111/jce.12267. Epub 2013 Oct 17.
Results Reference
result
PubMed Identifier
30821012
Citation
Dinshaw L, Schaffer B, Akbulak O, Jularic M, Hartmann J, Klatt N, Dickow J, Gunawardene M, Munkler P, Hakmi S, Pecha S, Sultan A, Luker J, Pinnschmidt H, Hoffmann B, Gosau N, Eickholt C, Willems S, Steven D, Meyer C. Long-term efficacy and safety of radiofrequency catheter ablation of atrial fibrillation in patients with cardiac implantable electronic devices and transvenous leads. J Cardiovasc Electrophysiol. 2019 May;30(5):679-687. doi: 10.1111/jce.13890. Epub 2019 Mar 10.
Results Reference
result
PubMed Identifier
12860855
Citation
Stewart S, Murphy NF, Walker A, McGuire A, McMurray JJ. The current cost of angina pectoris to the National Health Service in the UK. Heart. 2003 Aug;89(8):848-53. doi: 10.1136/heart.89.8.848. Erratum In: Heart. 2007 Nov;93(11):1472. Murphy, N [corrected to Murphy, N F].
Results Reference
result
PubMed Identifier
28964382
Citation
Jackson SL, Tong X, Yin X, George MG, Ritchey MD. Emergency Department, Hospital Inpatient, and Mortality Burden of Atrial Fibrillation in the United States, 2006 to 2014. Am J Cardiol. 2017 Dec 1;120(11):1966-1973. doi: 10.1016/j.amjcard.2017.08.017. Epub 2017 Aug 30.
Results Reference
result
PubMed Identifier
31510841
Citation
Ptaszek LM, Baugh CW, Lubitz SA, Ruskin JN, Ha G, Forsch M, DeOliveira SA, Baig S, Heist EK, Wasfy JH, Brown DF, Biddinger PD, Raja AS, Scirica B, White BA, Mansour M. Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study. J Am Heart Assoc. 2019 Sep 17;8(18):e012656. doi: 10.1161/JAHA.119.012656. Epub 2019 Sep 12.
Results Reference
result
PubMed Identifier
28506916
Citation
Calkins H, Hindricks G, Cappato R, Kim YH, Saad EB, Aguinaga L, Akar JG, Badhwar V, Brugada J, Camm J, Chen PS, Chen SA, Chung MK, Nielsen JC, Curtis AB, Davies DW, Day JD, d'Avila A, de Groot NMSN, Di Biase L, Duytschaever M, Edgerton JR, Ellenbogen KA, Ellinor PT, Ernst S, Fenelon G, Gerstenfeld EP, Haines DE, Haissaguerre M, Helm RH, Hylek E, Jackman WM, Jalife J, Kalman JM, Kautzner J, Kottkamp H, Kuck KH, Kumagai K, Lee R, Lewalter T, Lindsay BD, Macle L, Mansour M, Marchlinski FE, Michaud GF, Nakagawa H, Natale A, Nattel S, Okumura K, Packer D, Pokushalov E, Reynolds MR, Sanders P, Scanavacca M, Schilling R, Tondo C, Tsao HM, Verma A, Wilber DJ, Yamane T. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation. Heart Rhythm. 2017 Oct;14(10):e275-e444. doi: 10.1016/j.hrthm.2017.05.012. Epub 2017 May 12. No abstract available.
Results Reference
result
PubMed Identifier
25643988
Citation
Hakalahti A, Biancari F, Nielsen JC, Raatikainen MJ. Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis. Europace. 2015 Mar;17(3):370-8. doi: 10.1093/europace/euu376. Epub 2015 Feb 1.
Results Reference
result
PubMed Identifier
27042964
Citation
Kuck KH, Brugada J, Furnkranz A, Metzner A, Ouyang F, Chun KR, Elvan A, Arentz T, Bestehorn K, Pocock SJ, Albenque JP, Tondo C; FIRE AND ICE Investigators. Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2016 Jun 9;374(23):2235-45. doi: 10.1056/NEJMoa1602014. Epub 2016 Apr 4.
Results Reference
result
PubMed Identifier
28751544
Citation
Chun KRJ, Brugada J, Elvan A, Geller L, Busch M, Barrera A, Schilling RJ, Reynolds MR, Hokanson RB, Holbrook R, Brown B, Schluter M, Kuck KH; FIRE AND ICE Investigators. The Impact of Cryoballoon Versus Radiofrequency Ablation for Paroxysmal Atrial Fibrillation on Healthcare Utilization and Costs: An Economic Analysis From the FIRE AND ICE Trial. J Am Heart Assoc. 2017 Jul 27;6(8):e006043. doi: 10.1161/JAHA.117.006043. Erratum In: J Am Heart Assoc. 2017 Sep 15;6(9):
Results Reference
result
PubMed Identifier
30342299
Citation
Andrade JG, Champagne J, Deyell MW, Essebag V, Lauck S, Morillo C, Sapp J, Skanes A, Theoret-Patrick P, Wells GA, Verma A; EARLY-AF Study Investigators. A randomized clinical trial of early invasive intervention for atrial fibrillation (EARLY-AF) - methods and rationale. Am Heart J. 2018 Dec;206:94-104. doi: 10.1016/j.ahj.2018.05.020. Epub 2018 Oct 18.
Results Reference
result
PubMed Identifier
23577826
Citation
Kapa S, Epstein AE, Callans DJ, Garcia FC, Lin D, Bala R, Riley MP, Hutchinson MD, Gerstenfeld EP, Tzou W, Marchlinski FE, Frankel DS, Cooper JM, Supple G, Deo R, Verdino RJ, Patel VV, Dixit S. Assessing arrhythmia burden after catheter ablation of atrial fibrillation using an implantable loop recorder: the ABACUS study. J Cardiovasc Electrophysiol. 2013 Aug;24(8):875-81. doi: 10.1111/jce.12141. Epub 2013 Apr 11.
Results Reference
result
PubMed Identifier
24665920
Citation
Manganiello S, Anselmino M, Amellone C, Pelissero E, Giuggia M, Trapani G, Giordano B, Senatore G, Gaita F. Symptomatic and asymptomatic long-term recurrences following transcatheter atrial fibrillation ablation. Pacing Clin Electrophysiol. 2014 Jun;37(6):697-702. doi: 10.1111/pace.12387. Epub 2014 Mar 25.
Results Reference
result
PubMed Identifier
28201538
Citation
Reissmann B, Wissner E, Deiss S, Heeger C, Schlueter M, Wohlmuth P, Lemes C, Mathew S, Maurer T, Sohns C, Saguner A, Santoro F, Hayashi K, Riedl J, Ouyang F, Kuck KH, Metzner A. First insights into cryoballoon-based pulmonary vein isolation taking the individual time-to-isolation into account. Europace. 2017 Oct 1;19(10):1676-1680. doi: 10.1093/europace/euw233.
Results Reference
result
PubMed Identifier
29300976
Citation
Kotecha D, Breithardt G, Camm AJ, Lip GYH, Schotten U, Ahlsson A, Arnar D, Atar D, Auricchio A, Bax J, Benussi S, Blomstrom-Lundqvist C, Borggrefe M, Boriani G, Brandes A, Calkins H, Casadei B, Castella M, Chua W, Crijns H, Dobrev D, Fabritz L, Feuring M, Freedman B, Gerth A, Goette A, Guasch E, Haase D, Hatem S, Haeusler KG, Heidbuchel H, Hendriks J, Hunter C, Kaab S, Kespohl S, Landmesser U, Lane DA, Lewalter T, Mont L, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Pison L, Potpara T, Ravens U, Richard-Lordereau I, Rienstra M, Savelieva I, Schnabel R, Sinner MF, Sommer P, Themistoclakis S, Van Gelder IC, Vardas PE, Verma A, Wakili R, Weber E, Werring D, Willems S, Ziegler A, Hindricks G, Kirchhof P. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Europace. 2018 Mar 1;20(3):395-407. doi: 10.1093/europace/eux318.
Results Reference
result
PubMed Identifier
20958836
Citation
Pokushalov E, Romanov A, Corbucci G, Artyomenko S, Turov A, Shirokova N, Karaskov A. Ablation of paroxysmal and persistent atrial fibrillation: 1-year follow-up through continuous subcutaneous monitoring. J Cardiovasc Electrophysiol. 2011 Apr;22(4):369-75. doi: 10.1111/j.1540-8167.2010.01923.x. Epub 2010 Oct 11.
Results Reference
result

Learn more about this trial

From the Emergency Department Directly to Ablation of Atrial Fibrillation Study

We'll reach out to this number within 24 hrs