As Needed Versus Regular Intranasal Corticosteroid in Children With Perennial Allergic Rhinitis
Perennial Allergic Rhinitis, Child, Only
About this trial
This is an interventional treatment trial for Perennial Allergic Rhinitis
Eligibility Criteria
Inclusion Criteria:
- Children patient (age 6 - 18 yr)
- Mild persistent, Moderate to severe intermittent and persistent perennial allergic rhinitis
- Rhinitis proven sensitization to aeroallergen by positive skin prick test or specific IgE result within 12 month before study recruitment
- Mean TNSS = 4 during 7 day duration before randomization (after a washout period, discontinuation of the medications listed in exclusion criteria
Exclusion Criteria:
- Patients with rhinosinusitis, nasal polyps, or significant deviated nasal septum
- Patients with a history of uncontrolled asthma, chronic lung disease, cardiovascular, hepatic, or renal diseases
- Patients taking oral or nasal decongestants within 7 d
- Patients taking INCS within 4 week
- Patients taking systemic corticosteroid within 8 week
- Patients taking H1 antihistamine within 1 week
- Patients taking antileukotriene within 4 week
- Patients who were currently or previously treated with allergen immunotherapy
- Patients with a history of upper respiratory tract infection within 14 d
- Patients with primary and secondary immune deficiency
Sites / Locations
- Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
As needed INCs
Regular INCs
Use placebo everyday, and INCs as needed when the nasal symptom aggravated INCs = Fluticasone furoate nasal spray Placebo = Normal saline nasal spray Doses Fluticasone furoate nasal spray (27.5 mg/spray) age<12 yr:1 spray once daily 12 yr and older: 2 sprays once daily Normal saline nasal spray age<12 yr:1 spray once daily 12 yr and older: 2 sprays once daily
Use INCs everyday, and placebo as needed when the nasal symptom aggravated INCs = Fluticasone furoate nasal spray Placebo = Normal saline nasal spray Doses Fluticasone furoate nasal spray (27.5 mg/spray) age<12 yr:1 spray once daily 12 yr and older: 2 sprays once daily Normal saline nasal spray age<12 yr:1 spray once daily 12 yr and older: 2 sprays once daily