Reduced-dose Versus Standard Dose Radiotherapy for Nasopharyngeal Carcinomain
Nasopharyngeal Carcinoma
About this trial
This is an interventional treatment trial for Nasopharyngeal Carcinoma focused on measuring Nasopharyngeal Carcinoma, radiotherapy, induction chemotherapy
Eligibility Criteria
Inclusion Criteria:
- Patients newly diagnosed with histologically confirmed non-keratinizing NPC (WHO type II or III).
- Stage II-III(8thAJCC/UICC staging system)
- Aged 18-70 years
- ECOG = 0-1
- HGB≥90 g/L,WBC≥4×109 /L,PLT≥100×109 /L
- ALT,AST<1.5 x ULN;TBIL<1.5×ULN
- CCR≥60ml/min or Cr<1.5×ULN
- CR/PR and EBVDNA undetectable after induction chemotherapy
- Signed informed consent
Exclusion Criteria:
- WHO Type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma
- Age <18 or >70years
- Treatment with palliative intent
- Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer
- Pregnancy or lactation
- History of previous radiotherapy (except for non-melanomatous skin cancers outside intended RT treatment volume)
- Prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes
- Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose >1.5×ULN), and emotional disturbance
Sites / Locations
- Sun Yat-sen Universitty Cancer CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Reduced-dose group
Standard dose group
After 2 cycles of induction chemotherapy, patients with favorable response undergo low-dose (60Gy) intensity-modulated radiotherapy (IMRT) 5 days per week for approximately 6 weeks (30 fractions). Patients also receive concurrent cisplatin once every three weeks for 2 cycles.
After 2 cycles of induction chemotherapy, patients with favorable response undergo standard-dose (70Gy) intensity modulated radiotherapy (IMRT) 5 days per week for approximately 7 weeks (33 fractions). Patients also receive concurrent cisplatin once every three weeks for 3 cycles.