Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System
Obesity, Morbid, Anesthesia, Propofol
About this trial
This is an interventional basic science trial for Obesity, Morbid
Eligibility Criteria
Inclusion Criteria:
- ASA physical status II/III
- laparoscopic and non-laparoscopic surgery of more than 60-minutes duration
- Body mass index > 35kg/m2
Exclusion Criteria:
- Cardiovascular disorders (uncontrolled hypertension, Atrio-ventricular block, sinus bradycardia, congenital heart disease, reduced LV compliance & diastolic dysfunction)
- Neurological disorders (previous neurosurgery, psychiatric disorders, autonomic nervous system disorders- orthostatic hypotension, transient ischemic attacks)
- Hepato-renal insufficiency
- Uncontrolled diabetes mellitus
- Known allergy/hypersensitivity to study drug
- Pulmonary dysfunction (restrictive /obstructive lung disease)
- Acute/chronic drug dependence/substance abuse
Sites / Locations
- Nitin SethiRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Total Body Weight group
Adjusted Body Weight group
Anesthesia will be induced with Propofol administered by CLADS which will be set to deliver Propofol according to lean body weight (LBW). A BIS-value of 50 will be used as the target for induction of anesthesia. Thereafter anaesthesia maintenance will be done with Propofol, with the dosing based on total body weight (TBW), and administration controlled with CLADS tuned to consistent anaesthetic depth (BIS-50) feedback from the patients.
Anesthesia will be induced with Propofol administered by CLADS which will be set to deliver Propofol according to lean body weight (LBW). A BIS-value of 50 will be used as the target for induction of anesthesia. Thereafter anaesthesia maintenance will be done with Propofol, with the dosing based on adjusted body weight (ABW), and administration controlled with CLADS tuned to consistent anaesthetic depth (BIS-50) feedback from the patients.