RETRIEVE-AMI Study (RETRIEVE-AMI)
Myocardial Infarction, Thrombus, Coronary Artery Disease
About this trial
This is an interventional treatment trial for Myocardial Infarction focused on measuring Myocardial Infarction, Percutaneous coronary intervention, Stent Retriever, Thrombus Aspiration
Eligibility Criteria
Inclusion Criteria:
- Primary PCI patient with inferior ST elevation myocardial infarction (STEMI)
- Right coronary culprit artery
- TIMI 0 flow at presentation
- Angiographic thrombus score ≥ 4
- Occlusion prior to the crux
- Vessel diameter at site of occlusion ≥ 3.0 mm (measured by quantitative coronary angiography)
Exclusion Criteria:
- Female participant who is pregnant or lactating
- Participant with known hypersensitivity to nickel-titanium
- Unconscious at presentation
- Late presenter (pain to wire time > 6 h)
- Class Killip III/IV and/or profound bradycardia (Heart rate < 40 bpm)
- Known history of kidney failure
- Ostial right coronary artery (RCA) occlusion
- Highly tortuous vessel
- Highly calcified vessel
- Suspected (angiographically) spontaneous coronary artery dissection
- Stent thrombosis
- Previous stent implanted in the RCA proximally to the occlusion site
- Previous coronary artery bypass graft surgery (CABG)
- Previous STEMI/Transient Ischemic Attack/Stroke
- Known anaemia (Hemoglobin <9)
Sites / Locations
- Oxford Heart CentreRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Experimental
Standalone Percutaneous Coronary Intervention
Percutaneous Coronary Intervention and Thrombus Aspiration
Percutaneous Coronary Intervention and Retriever Thrombectomy
Participants will have standard of care treatment. They will undergo PCI with devices and techniques driven by clinical decision making at the patient level and institutional level, and carried out in accordance with the Oxford University Hospitals NHS Foundation Trust department guidelines.
Participants will have standard of care treatment with manual thrombectomy catheter and PCI. They will undergo PCI with devices and techniques driven by clinical decision making at the patient level and institutional level, and carried out in accordance with the Oxford University Hospitals NHS Foundation Trust department guidelines.
Participants randomised to the stent-retriever thrombectomy arm of the RETRIEVE AMI trial will undergo stent-retriever thrombectomy with the SolitaireTM X Revascularisation Device.