Bladder and Bowel Dysfunction in Children
Bladder and Bowel Dysfunction
About this trial
This is an interventional treatment trial for Bladder and Bowel Dysfunction focused on measuring Dysfunctional Elimination Syndrome, Urinary Incontinence in Children, Functional constipation in Children, Gut Microbiome, Urine Microbiome
Eligibility Criteria
Inclusion Criteria:
- Age 5-14 years and 9 months at time of inclusion
- Diagnosed with urinary incontinence and/or enuresis nocturna defined by the ICCS criteria
- Diagnosed with constipation and/or faecal incontinence defined by the ROME IV criteria
- Normal clinical examination
- Parents/guardian can understand the written and spoken information
- Informed assent to participation from both parents/guardian
Exclusion Criteria:
- Neuropathic or anatomical abnormalities in the urinary tract or gastrointestinal canal
- Earlier surgical intervention of the urinary tract (except circumcision)
- Neurological illness or earlier cerebral surgical intervention
- On-going urinary tract infection
- On-going treatment with anticholinergics and/or β3-adenoceptoragonist
- On-going treatment with laxatives in correct dosage (PEG3350 1-2 g/kg/day)
- Inflammatory bowel disease
- Other disorder affection bladder or bowel function
- For Study 2 (microbiome): Systemic antibiotics within the past 3 months
Sites / Locations
- Aalborg University Hospital
- Aarhus University HospitalRecruiting
- Goedstrup Regional HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Treatment of constipation and/or faecal incontinence
Treatment of constipation and/or faecal incontinence combined with urotherapy
Medical treatment of bowel symptoms in accordance with the guidelines of The European Society for Paediatric Gastroenterology, Hepatology and Nutrition
Medical treatment of bowel symptoms in accordance with the guidelines of The European Society for Paediatric Gastroenterology, Hepatology and Nutrition combined with standard urotherapy in accordance with International Children's Continence Society (ICCS)