Fecal Microbiota Transplantation in Pediatric Crohn's Disease (FMT)
Crohn Disease
About this trial
This is an interventional treatment trial for Crohn Disease focused on measuring fecal microbiota transplantation , Crohn Disease
Eligibility Criteria
Inclusion Criteria:
Aged 2-16 years and without genetic diseases; All refractory pediatric with mild-to-moderate CD; Mild-to-moderate CD, defined by the pediatric Crohn's disease activity index (PCDAI) >10 and ≤40 and Simple Endoscopic Score for CD (SES-CD) > 3 were enrolled in the study; refractory CD, defined by children who failed conventional treatment (hormone, immunosuppressant, biologics)
Exclusion Criteria Children who were treated by PEN (80%) less than 8 weeks; follow up less than 3 months; known contraindication to all FMT infusion method such as nasoduodenal tube insertion, oesophago-gastro-duodenoscopy (OGD), enteroscopy, colonoscopy and enema; unwilling to give informed consent/assent
Sites / Locations
- Tongji HospitalRecruiting
Arms of the Study
Arm 1
Experimental
Repeated and multiple FMTs plus PEN
repeated and multiple FMTs plus PEN(50% of total calories as polymeric diet, Peptamen, Nestle, Vevey, Switzerland) in refractory pediatric CD