Change from baseline in electromyography of eccentric acting muscles
Muscle activation during weight acceptance while walking on a treadmill
Change from baseline in kinetics during weight acceptance
Peak magnitude of loading response as measured by the peak magnitude of power absorption during the weight acceptance phase of walking on a treadmill
Change from baseline in kinematics during weight acceptance: hip range of motion
Range of motion of the hip joint during walking on a treadmill
Change from baseline in kinematics during weight acceptance: knee range of motion
Range of motion of the knee joint during walking on a treadmill
Change from baseline in kinematics during weight acceptance: ankle range of motion
Range of motion of the ankle joint during walking on a treadmill
Change from baseline in kinematics during weight acceptance: hip acceleration
Acceleration of the hip joint during walking on a treadmill
Change from baseline in kinematics during weight acceptance: knee acceleration
Acceleration of the knee joint during walking on a treadmill
Change from baseline in kinematics during weight acceptance: ankle acceleration
Acceleration of the ankle joint during walking on a treadmill
Change from baseline in myelination in brain and spinal cord measured by Magnetic Resonance Imaging (MRI)
Myelin spared pre and post intervention in the motor areas of the brain and cervical spinal cord compared to healthy controls
Change from baseline in ASIA Impairment Scale (AIS)
Classification of injury using grades A, B, C, D or E indicating level of impairment including complete (A), sensory incomplete (B), or motor incomplete (C and D). A classification differences between C and D indicates if less or more than half (respectively) of myotomes below the level of injury are able to at least move through the full range of motion against gravity. A grade of E indicates normal sensory and strength function.
Change from 12 weeks to 16 weeks in American Spinal Injury Association (ASIA) Impairment Scale (AIS)
Classification of injury using grades A, B, C, D or E indicating level of impairment including complete (A), sensory incomplete (B), or motor incomplete (C and D). A classification differences between C and D indicates if less or more than half (respectively) of myotomes below the level of injury are able to at least move through the full range of motion against gravity. A grade of E indicates normal sensory and strength function.
Change from baseline in International Standards for Neurological Classification of SCI (ISNCSCI): motor scores
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. Motor scores range from 0-50 for each the right and left sides and 50 for each the upper extremities and lower extremities. A higher score indicates better outcomes (strength).
Change from 12 weeks to 16 weeks in International Standards for Neurological Classification of SCI (ISNCSCI): motor scores
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. Motor scores range from 0-50 for each the right and left sides and 50 for each the upper extremities and lower extremities. A higher score indicates better outcomes (strength).
Change from baseline in International Standards for Neurological Classification of SCI (ISNCSCI): sensory scores
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. Sensory scores range from 0-112 for each the right and left sides. A higher score indicates better outcomes (sensation).
Change from 12 weeks to 16 weeks in International Standards for Neurological Classification of SCI (ISNCSCI): sensory scores
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. Sensory scores range from 0-112 for each the right and left sides. A higher score indicates better outcomes (sensation).
Change from baseline in International Standards for Neurological Classification of SCI (ISNCSCI): neurological level of injury (NLI)
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. NLI can range from the first level of the cervical spinal cord (C1) indicating tetraplegia (C1-thoracic, T1) to the final sacral level (S4-5) which would indicate paraplegia.
Change from 12 weeks to 16 weeks in International Standards for Neurological Classification of SCI (ISNCSCI): neurological level of injury (NLI)
A universal classification tool for SCI based on a standardized sensory and motor assessment. The impairment scale involves both a motor and sensory examination to determine the sensory and motor levels for the right and left side, the overall neurological level of the injury and completeness of the injury i.e. whether the injury is complete or incomplete. NLI can range from the first level of the cervical spinal cord (C1) indicating tetraplegia (C1-thoracic, T1) to the final sacral level (S4-5) which would indicate paraplegia.
Change from baseline on Autonomic Standards Assessment Form
International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI). Patient self-reported responses include normal (2) when there is no change in neurological control with respect to a specific function; reduced or altered (1) neurological control with regard to a specific function; absent (0) neurological control with regard to a specific function; and unable to assess a specific function (not testable, NT).
Change from 12 weeks to 16 weeks on Autonomic Standards Assessment Form
International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI). Patient self-reported responses include normal (2) when there is no change in neurological control with respect to a specific function; reduced or altered (1) neurological control with regard to a specific function; absent (0) neurological control with regard to a specific function; and unable to assess a specific function (not testable, NT).
Change from baseline on Neuromuscular Recovery Scale (NRS) score
Measures quality of movement without compensation. Scored in phases 1-4 with subphases A-C, with scores indicating most impairment (1A, numeric value of 1-1.99) to least impairment (4C, numeric value of 12).
Change from 12 weeks to 16 weeks on Neuromuscular Recovery Scale (NRS) score
Measures quality of movement without compensation. Scored in phases 1-4 with subphases A-C, with scores indicating most impairment (1A, numeric value of 1) to least impairment (4C, numeric value of 12).
Change from baseline in 6 Minute Walk Test (6MWT)
The distance walked overground within 6 minutes (meters).
Change from 12 weeks to 16 weeks in 6 Minute Walk Test (6MWT)
The distance walked overground within 6 minutes (meters).
Change from baseline in 10 Meter Walk Test
Gait speed - the time it takes to walk 10 meters (seconds)
Change from 12 weeks to 16 weeks in 10 Meter Walk Test
Gait speed - the time it takes to walk 10 meters (seconds)
Change from baseline in Spinal Cord Independence Measure III (SCIM3) score
Assessment of various activities of daily living. Scoring ranges per category: Self-care subscale, Items 1-4 (0-20); Respiration and sphincter management subscale, Items 5-8 (0-40); Mobility subscale, Items 9-17 (0-40) with higher scores indicating more independence.
Change from 12 weeks to 16 weeks in Spinal Cord Independence Measure III (SCIM3) score
Assessment of various activities of daily living. Scoring ranges per category: Self-care subscale, Items 1-4 (0-20); Respiration and sphincter management subscale, Items 5-8 (0-40); Mobility subscale, Items 9-17 (0-40) with higher scores indicating more independence.
Change from baseline in Neuropathic Pain Symptom Inventory (NPSI) scale
Characterization of neuropathic pain symptom severity in 5 subscales (burning, pressing, paroxysmal, evoked, and paresthesia/dysesthesia. Each item is scored on a scale of 0 (indicating no pain) to 10 (worst pain imaginable). Each subscale is added then divided by 100, giving a total score ranging from 0-1 with scores closest to 1 indicating worse pain.
Change from 12 weeks to 16 weeks in Neuropathic Pain Symptom Inventory (NPSI) scale
Characterization of neuropathic pain symptom severity in 5 subscales (burning, pressing, paroxysmal, evoked, and paresthesia/dysesthesia. Each item is scored on a scale of 0 (indicating no pain) to 10 (worst pain imaginable). Each subscale is added then divided by 100, giving a total score ranging from 0-1 with scores closest to 1 indicating worse pain.
Change from baseline in Numeric Pain Rating Scale (NPRS)
Subjective measure of the intensity of pain on a scale if 0-10, with a higher score indicating worse pain.
Change from 12 weeks to 16 weeks in Numeric Pain Rating Scale (NPRS)
Subjective measure of the intensity of pain on a scale if 0-10, with a higher score indicating worse pain.
Change from baseline in Strength Testing
Maximum voluntary eccentric knee flexion contraction after performing eccentric activity on the contralateral limb (i.e., the contralateral priming effect) measured by a Biodex.
Change from 12 weeks to 16 weeks in Strength Testing
Maximum voluntary eccentric knee flexion contraction after performing eccentric activity on the contralateral limb (i.e., the contralateral priming effect) measured by a Biodex.
Change from baseline in electromyography of eccentric acting muscles at 12 weeks
Muscle activation during weight acceptance while walking on a treadmill
Change from 12 weeks to 16 weeks in kinetics during weight acceptance
Peak magnitude of loading response as measured by the peak magnitude of power absorption during the weight acceptance phase of walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: hip range of motion
Range of motion of the hip joint during walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: knee range of motion
Range of motion of the knee joint during walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: ankle range of motion
Range of motion of the ankle joint during walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: hip acceleration
Acceleration of the hip joint during walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: knee acceleration
Acceleration of the knee joint during walking on a treadmill
Change from 12 weeks to 16 weeks in kinematics during weight acceptance: ankle acceleration
Acceleration of the ankle joint during walking on a treadmill