Low Dose Prasugrel vs Clopidogrel for Stenting or Flow Diverter for Unruptured Aneurysm
Intracranial Aneurysm
About this trial
This is an interventional treatment trial for Intracranial Aneurysm focused on measuring Intracranial Aneurysm, Clopidogrel, Prasugrel Hydrochloride
Eligibility Criteria
Inclusion Criteria:
- UIAs without any evidence of rupture in intracranial imaging study within the last 6 months
- Planned treatment with coil embolization with stent insertion or flow diverter insertion
- If the patient himself/herself consented to this study
Exclusion Criteria:
∙ History of acute ischemic stroke or transient ischemic attack
- Any intracranial hemorrhage except subarachnoid hemorrhage due to aneurysm rupture within the last 3 months
- Concurrent treatment other than endovascular procedure (e.g. open craniotomy and microsurgical clipping)
- Contraindications to iodine contrast agents
- Already taking antiplatelet drugs or antithrombotic drugs other than aspirin
- Hypersensitivity to aspirin, prasugrel or clopidogrel
- Cardiac arrhythmia that should be needed to take anticoagulants
- Pregnancy or lactating
- Chronic kidney disease (< GFR 60)
- Patients with chronic liver disease who have at least over 100 IU/L of either AST/ALT in the liver function test
- Patients with pathological active bleeding, such as peptic ulcer
- Patients with genetic problems, such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption because they contain lactose
- Patients continuously taking non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 inhibitors
- Patients requiring concomitant administration of methotrexate 15 mg or more for one week
- If it is judged difficult to follow up after treatment
Sites / Locations
- Yongin Severance hospital, Yonsei university college of medicineRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Clopidogrel
prasugrel
Using a randomization program, the test group (203 patients; Aspirin 100 mg + Prasugrel 5 mg) and control group (203 patients; Aspirin 100 mg + Clopidogrel 75 mg) are classified. Prescribe the above drugs according to the assigned group, and take them 5 days before the procedure.
Using a randomization program, the test group (203 patients; Aspirin 100 mg + Prasugrel 5 mg) and control group (203 patients; Aspirin 100 mg + Clopidogrel 75 mg) are classified. Prescribe the above drugs according to the assigned group, and take them 5 days before the procedure.