Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation
Chronic Pain, rTMS
About this trial
This is an interventional diagnostic trial for Chronic Pain
Eligibility Criteria
Inclusion Criteria:
1)woman or man over 18 and under 85 years old; 2)Clinical diagnosis of physical and mental health people; 3) able to cooperate in completing questionnaire.
Exclusion Criteria:
1)Clinical diagnosis of psychiatric disorder including major depression; 2) History of substance abuse (alcohol, drugs); 3) Past treatment with repetitive transcranial magnetic stimulation (rTMS); 4) Contraindications to rTMS (previous severe head trauma or neurosurgical intervention, past or current epilepsy, active brain tumor, intracranial hypertension, implanted ferromagnetic devices, e.g., cardiac pacemaker, neurostimulator, or cochlear implants); 5) Any difficulty to fill out questionnaires (due to language or cognitive problems);
Sites / Locations
- The second affiliated hospital of Zhejiang University hangzhou
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
active stimulation of M1
active stimulation of DLPFC
SHAM stimulation
pcTBS was administered to the left M1 at 80% resting motor threshold (RMT), consisting of a burst of 3 pulses given at 50 Hz repeated every 5 Hz. A total of 1,200 pulses were delivered with the TMS coil positioned in a posterior-anterior (PA) direction parallel to the midline.
pcTBS was administered to the left DLPFC at 80% resting motor threshold (RMT), consisting of a burst of 3 pulses given at 50 Hz repeated every 5 Hz. A total of 1,200 pulses were delivered with the TMS coil positioned in a posterior-anterior (PA) direction parallel to the midline.
The Sham stimulation was delivered using the same protocol, with the coil being orientated at 90° to the scalp so that the magnetic field would be delivered away from the scal