New Cross-linked Hyaluronan Gel to Prevent Adhesion After USG-MVA: RCT
First Trimester Abortion, Surgical Abortion, Miscarriage With Afibrinogenemia
About this trial
This is an interventional prevention trial for First Trimester Abortion focused on measuring First Trimester Abortion, Surgical Abortion, Intrauterine adhesion, Hyaluronan gel, Protective Agents, Hyaluronic Acid, Manual vacuum aspiration, Miscarriage
Eligibility Criteria
Inclusion Criteria:
- Women 18 years old or above
- No previous history of IUA/ Asherman's syndrome
- No previous surgical history of EVA or dilatation or curettage or surgical termination of pregnancy or caesarean section
- No previous history of therapeutic hysteroscopic surgeries
- Voluntary informed consent and understanding of study
Exclusion Criteria:
- previous therapeutic hysteroscopic procedures (e.g. endometrial ablation, removal of fibroids or polyps, surgical correction of congenital uterine anomalies or adhesiolysis)
- suspicion of molar pregnancy
- genital tract malformation
- suspicion of active infection or genital tract malignancy or genital tuberculosis
- abnormal blood coagulation
- inability to tolerate pelvic examination known
- suspected intolerance of hypersensitivity to NCH gel or its derivatives
- patient refusal
Sites / Locations
- The Chinese University of Hong KongRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Intervention group (Group A): NCH gel after USG-MVA
Controlled group (Group B): No NCH gel after USG-MVA
In the intervention group (Group A), a 15 cm sterile delivery cannula will be inserted through the internal os and a syringe of NCH gel (5ml) will be applied to the uterine cavity after cleansing the cervix with an antiseptic solution.
In the control group (Group B), as the patient is conscious during the procedure, an empty 5ml syringe will be inserted into the internal os and held for 1 minute as a sham procedure.