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Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn

Primary Purpose

Heartburn

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)
Placebo 1.4 ml
Sponsored by
Microbiome Health Sciences
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Heartburn focused on measuring Heartburn, microbiome, acid reflux, PIMO, indigestion

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

For Screening Phase inclusion, subjects must meet all the following inclusion criteria to be eligible for enrollment into the study:

  1. Subject is willing and able to participate in the study for the required duration, understand and provide signed informed consent, and agrees to undergo all protocol activities.
  2. Subject is proficient in reading, writing, and speaking English.
  3. Subject is able to complete all required electronic Daily RESQ-eD questionnaires, daily medication questionnaires (Screening Phase, Product/Placebo Phase, Product Phase, and Follow-up Phase), daily General Well-being questionnaire (Screening Phase Only), 4-item Patient Health Questionnaire for Depression and Anxiety (PHQ-4) (Screening Phase Day 14), and monthly Participant Global Assessment questionnaire (Product/Placebo Phase, Product Phase).
  4. Have access to a computer/tablet/phone with internet access and active e-mail account in order to complete electronic surveys daily throughout study participation.
  5. Males or females between 18 and 75 years of age (inclusive), with a BMI ≥ 19 and < 35 kg/m2.
  6. Females must not be pregnant or lactating.
  7. Female Subjects of non-childbearing potential whether surgically sterile or postmenopausal
  8. Female Subjects of childbearing potential must agree to use adequate contraception from the time of informed consent to the last dose of study product or placebo.
  9. Must be on stable doses of medications, if any, prescribed for chronic conditions.
  10. Subject must be taking daily PPI (defined as 5 to 7 days per week) of no more than one type (see "a" through "f" below) at no more than twice the standard prescription dose for their specific PPI type, for 4 consecutive weeks prior to the Screening Call, selected from the following list of medications:

    1. omeprazole (no more than 40 mg/day)
    2. esomeprazole (no more than 40 mg/day)
    3. lansoprazole (no more than 60 mg/day)
    4. dexlansoprazole (no more than 60 m/dayg)
    5. pantoprazole (no more than 80 mg/day)
    6. rabeprazole (no more than 40 mg/day)
  11. History of a minimum of 3 months of heartburn (ie, "burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn" per questions 1, 2 or 3 of RESQ-eD).

Exclusion Criteria:

  1. Subject has not maintained a stable diet for ≥ 30 days prior to the Screening Call or is unwilling to maintain a stable diet during the study.
  2. Subject has had a surgical procedure requiring general anesthesia < 60 days prior to the Screening Call.
  3. Subject has had a colonoscopy in the past 30 days or is scheduled for colonoscopy within the next 4 months and is unable/unwilling to postpone until the completion of study participation.
  4. Subject has a history of cancer (other than basal cell carcinoma of the skin) unless the malignancy has been in a complete remission without maintenance therapy (eg, chemotherapy, radiation, surgery) for ≥ 5 years prior to the Screening Call.
  5. Subject has any acute or chronic illness that could confound outcome assessments for this study, including, but not limited to:

    1. Known history of untreated peptic or gastric ulcer or Helicobacter pylori (H pylori) positivity without a history of successful treatment.
    2. Known history of ulcerative colitis, Crohn's disease, colon cancer, current stomach ulcers, pancreatitis, diverticulitis
    3. Known history of acute or chronic hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection
    4. Known or suspected alcoholism, drug addiction, or significant drug abuse within 1 year of the Screening Call
  6. Subject has any known medical condition, clinical signs and symptoms, vital signs, abnormal laboratory, or other testing, considered clinically significant by the Investigator, that could interfere with the subject's participation in and completion of the study including, but not limited to:

    1. Uncontrolled hypertension
    2. Diabetes uncontrolled by diet (ie, requiring oral medication or insulin)
    3. Previous anaphylactic reaction to any medication
    4. History of adrenal disease, diabetic nephropathy, or gastroparesis
    5. Uncontrolled hypothyroidism
    6. Untreated mental disorder
    7. Spinal cord injury
  7. Subject has had a cerebrovascular event (stroke) or myocardial infarction (MI) in the last 6 months
  8. Subject has a physiologic or structural abnormality of the GI tract, or disease or condition that can affect GI motility, or defecation
  9. Subject has plans to travel outside the USA during the study period
  10. Subject has a current COVID19 infection, or a history of a prior COVID19 infection with ongoing symptoms suggestive of "Long COVID"
  11. History of scleroderma, Barrett's esophagus, esophageal cancer, esophageal stricture, or esophageal scarring
  12. History of endoscopically determined erosive esophagitis of all classes (eg, LA grade A through D)
  13. Known hiatal hernia > 2cm
  14. History of surgery or endoscopic treatment including fundoplication and dilation for esophageal stricture
  15. History of gastric surgery (except for endoscopic removal of benign polyps) or bariatric surgery
  16. Subject has had a barium enema within 30 days of the Screening Call
  17. Subject has had a fecal impaction that required hospitalization or emergency room treatment within 3 months of the Screening Call
  18. Subject has a history diagnosis of an eating disorder in the last 5 years
  19. Subject has a history of substantiated (documented by computed tomography (CT) scan or hospitalization) diverticulitis, or any ongoing chronic condition (eg, polycystic kidney disease, endometriosis, ovarian cysts, or other) that may be associated with chronic abdominal pain or discomfort and might confound the assessments in this study during the 2 years prior to the Screening Call
  20. Subject has had surgery that meets any of the following criteria:

    1. Gastric bypass surgery or invasive procedure for the treatment of obesity or surgery to remove a segment of the GI tract at any time prior to the Screening Call
    2. Subjects who have had a gastric band unless the band has been completely removed > 60 days prior to the Screening Call
    3. Open surgery of the abdomen, pelvis, or retroperitoneal structures within 6 months prior to the Screening Call
    4. Laparoscopic appendectomy or cholecystectomy or other instrumentation of the bowel < 60 days prior to the Screening Call
  21. Prior use of the Study Product MHS-1031
  22. History of any the following diseases that can cause heartburn (ie, "burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn" per RESQ-eD question 1, 2, or 3): eosinophilic esophagitis, angina, esophageal spasm, achalasia, rumination, or other conditions involving the mouth, throat, dysphagia, or dyspnea
  23. Active history of nicotine use, cannabis use, or alcohol abuse (defined as: > 14 drinks/week or 4 drinks/day for men, 7 drinks/week or 3 drinks/day for women). Has used any tobacco, nicotine, or cannabis products (of any type) in the last 6 months or has abused alcohol in the last 6 months
  24. Taking any excluded medications listed in the protocol (eg, metformin, antibiotics within the prior 6 months, and during the study)
  25. If female, is pregnant, lactating, or intending to become pregnant before or while participating in this study or intending to donate ova during such time period
  26. Use of colon prep or high colonic within 30 days prior to the Screening Call
  27. Narcotic (eg, opiate) use within 60 days of the Screening Call
  28. Antibiotic use within 60 days of the Screening Call
  29. Use of any investigational product within 3 months or five half-lives (whichever is longer) prior to study entry
  30. Participation in another investigation (clinical trial) during the course of this study
  31. Participation in a rigorous weight loss program or have any planned changes in diet or lifestyle, such as getting married, change in residence, change in job, or other highly stressful event
  32. Diagnosis of inflammatory bowel disease, irritable bowel syndrome (IBS-D and IBSC), Chronic Idiopathic Constipation
  33. Regular use (ie, >=4 times per month) of antibacterial mouthwash (eg, Listerine, Scope, others) and unwilling to stop use for the duration of the study
  34. Subject previously took PPIs daily for heartburn, for at least 7 consecutive days in the past, and experienced no improvement
  35. Subject is employed by (or is a relative of an employee) or is involved in any way with Microbiome Health Sciences
  36. Other conditions or situations that, in the investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study

Sites / Locations

  • Microbiome Health Sciences

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Product Tolerability Arm

Placebo Tolerability Arm

Arm Description

Study Product MHS-1031 1g (1.4 ml) per day

Placebo (Neotame 7.92 mcg/g, phosphoric acid, and sterile water) 1.4 ml per day

Outcomes

Primary Outcome Measures

Tolerability as recorded via RESQ-eD (online PRO) questions
Tolerability is defined as the proportion of subjects at day 56 with number of days reporting heartburn no greater than baseline. The number of "heartburn days" is defined as the number of days where an answer of >0 (ie, Not "0 - Did not have") is recorded for any of the RESQ-eD questions: "burning feeling behind your breastbone", "pain behind your breastbone", and "heartburn". Subjects who are missing at day 56 will be considered to have not tolerated the study product or to have not tolerated the placebo.

Secondary Outcome Measures

Full Information

First Posted
April 27, 2022
Last Updated
July 14, 2023
Sponsor
Microbiome Health Sciences
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1. Study Identification

Unique Protocol Identification Number
NCT05363618
Brief Title
Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn
Official Title
A Parallel Randomized, Blinded, Un-controlled Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo, in Subjects With Heartburn
Study Type
Interventional

2. Study Status

Record Verification Date
July 2023
Overall Recruitment Status
Completed
Study Start Date
February 10, 2022 (Actual)
Primary Completion Date
May 30, 2023 (Actual)
Study Completion Date
May 30, 2023 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Microbiome Health Sciences

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Remote un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in subjects with heartburn. Candidates will have heartburn and be taking daily PPIs at up to twice the standard OTC or prescription dosage. Approximately 400 subjects (men and women of all races and ethnicities) will be randomly enrolled in a 1:1 ratio to receive Product or Placebo (1.4 ml) per day.
Detailed Description
This study will be conducted as a remote un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in two similar subject groups with heartburn. Candidates will have heartburn and be taking daily PPIs at up to twice the standard OTC or prescription dosage. Approximately 400 subjects (men and women of all races and ethnicities) will be randomly enrolled in a 1:1 ratio to receive Product or Placebo (1.4 ml) per day. Screening phase: 14 days Product/Placebo phase: 56 days. From Day 1 through Day 28 each subject will continue taking their usual daily PPI. Beginning on Day 29 and through Day 56 subjects will be requested to not take a PPI. Subjects may re-start taking a PPI at any time. Product Phase: 28 days. All subjects will receive MHS-1031. Follow-Up Phase: Subjects who complete the Product Phase of the study will enter into a 14-day Follow-up Phase, during which subjects will take neither placebo nor MHS-1031. For entry into the Screening Phase, subjects must have the following history: Heartburn experienced at least 1 day per week while taking a PPI. During the study, tolerability will be assessed via on-line validated PRO questionnaires and assessment of adverse events. Tolerability is defined as no overall worsening of heartburn measurement scores after 8 weeks of taking the product or the placebo compared to baseline scores.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Heartburn
Keywords
Heartburn, microbiome, acid reflux, PIMO, indigestion

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
A remote, randomized, blinded, un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in two similar subject groups with heartburn.
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
211 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Product Tolerability Arm
Arm Type
Active Comparator
Arm Description
Study Product MHS-1031 1g (1.4 ml) per day
Arm Title
Placebo Tolerability Arm
Arm Type
Placebo Comparator
Arm Description
Placebo (Neotame 7.92 mcg/g, phosphoric acid, and sterile water) 1.4 ml per day
Intervention Type
Dietary Supplement
Intervention Name(s)
Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)
Intervention Description
Active study product
Intervention Type
Other
Intervention Name(s)
Placebo 1.4 ml
Intervention Description
Placebo
Primary Outcome Measure Information:
Title
Tolerability as recorded via RESQ-eD (online PRO) questions
Description
Tolerability is defined as the proportion of subjects at day 56 with number of days reporting heartburn no greater than baseline. The number of "heartburn days" is defined as the number of days where an answer of >0 (ie, Not "0 - Did not have") is recorded for any of the RESQ-eD questions: "burning feeling behind your breastbone", "pain behind your breastbone", and "heartburn". Subjects who are missing at day 56 will be considered to have not tolerated the study product or to have not tolerated the placebo.
Time Frame
8 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: For Screening Phase inclusion, subjects must meet all the following inclusion criteria to be eligible for enrollment into the study: Subject is willing and able to participate in the study for the required duration, understand and provide signed informed consent, and agrees to undergo all protocol activities. Subject is proficient in reading, writing, and speaking English. Subject is able to complete all required electronic Daily RESQ-eD questionnaires, daily medication questionnaires (Screening Phase, Product/Placebo Phase, Product Phase, and Follow-up Phase), daily General Well-being questionnaire (Screening Phase Only), 4-item Patient Health Questionnaire for Depression and Anxiety (PHQ-4) (Screening Phase Day 14), and monthly Participant Global Assessment questionnaire (Product/Placebo Phase, Product Phase). Have access to a computer/tablet/phone with internet access and active e-mail account in order to complete electronic surveys daily throughout study participation. Males or females between 18 and 75 years of age (inclusive), with a BMI ≥ 19 and < 35 kg/m2. Females must not be pregnant or lactating. Female Subjects of non-childbearing potential whether surgically sterile or postmenopausal Female Subjects of childbearing potential must agree to use adequate contraception from the time of informed consent to the last dose of study product or placebo. Must be on stable doses of medications, if any, prescribed for chronic conditions. Subject must be taking daily PPI (defined as 5 to 7 days per week) of no more than one type (see "a" through "f" below) at no more than twice the standard prescription dose for their specific PPI type, for 4 consecutive weeks prior to the Screening Call, selected from the following list of medications: omeprazole (no more than 40 mg/day) esomeprazole (no more than 40 mg/day) lansoprazole (no more than 60 mg/day) dexlansoprazole (no more than 60 m/dayg) pantoprazole (no more than 80 mg/day) rabeprazole (no more than 40 mg/day) History of a minimum of 3 months of heartburn (ie, "burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn" per questions 1, 2 or 3 of RESQ-eD). Exclusion Criteria: Subject has not maintained a stable diet for ≥ 30 days prior to the Screening Call or is unwilling to maintain a stable diet during the study. Subject has had a surgical procedure requiring general anesthesia < 60 days prior to the Screening Call. Subject has had a colonoscopy in the past 30 days or is scheduled for colonoscopy within the next 4 months and is unable/unwilling to postpone until the completion of study participation. Subject has a history of cancer (other than basal cell carcinoma of the skin) unless the malignancy has been in a complete remission without maintenance therapy (eg, chemotherapy, radiation, surgery) for ≥ 5 years prior to the Screening Call. Subject has any acute or chronic illness that could confound outcome assessments for this study, including, but not limited to: Known history of untreated peptic or gastric ulcer or Helicobacter pylori (H pylori) positivity without a history of successful treatment. Known history of ulcerative colitis, Crohn's disease, colon cancer, current stomach ulcers, pancreatitis, diverticulitis Known history of acute or chronic hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection Known or suspected alcoholism, drug addiction, or significant drug abuse within 1 year of the Screening Call Subject has any known medical condition, clinical signs and symptoms, vital signs, abnormal laboratory, or other testing, considered clinically significant by the Investigator, that could interfere with the subject's participation in and completion of the study including, but not limited to: Uncontrolled hypertension Diabetes uncontrolled by diet (ie, requiring oral medication or insulin) Previous anaphylactic reaction to any medication History of adrenal disease, diabetic nephropathy, or gastroparesis Uncontrolled hypothyroidism Untreated mental disorder Spinal cord injury Subject has had a cerebrovascular event (stroke) or myocardial infarction (MI) in the last 6 months Subject has a physiologic or structural abnormality of the GI tract, or disease or condition that can affect GI motility, or defecation Subject has plans to travel outside the USA during the study period Subject has a current COVID19 infection, or a history of a prior COVID19 infection with ongoing symptoms suggestive of "Long COVID" History of scleroderma, Barrett's esophagus, esophageal cancer, esophageal stricture, or esophageal scarring History of endoscopically determined erosive esophagitis of all classes (eg, LA grade A through D) Known hiatal hernia > 2cm History of surgery or endoscopic treatment including fundoplication and dilation for esophageal stricture History of gastric surgery (except for endoscopic removal of benign polyps) or bariatric surgery Subject has had a barium enema within 30 days of the Screening Call Subject has had a fecal impaction that required hospitalization or emergency room treatment within 3 months of the Screening Call Subject has a history diagnosis of an eating disorder in the last 5 years Subject has a history of substantiated (documented by computed tomography (CT) scan or hospitalization) diverticulitis, or any ongoing chronic condition (eg, polycystic kidney disease, endometriosis, ovarian cysts, or other) that may be associated with chronic abdominal pain or discomfort and might confound the assessments in this study during the 2 years prior to the Screening Call Subject has had surgery that meets any of the following criteria: Gastric bypass surgery or invasive procedure for the treatment of obesity or surgery to remove a segment of the GI tract at any time prior to the Screening Call Subjects who have had a gastric band unless the band has been completely removed > 60 days prior to the Screening Call Open surgery of the abdomen, pelvis, or retroperitoneal structures within 6 months prior to the Screening Call Laparoscopic appendectomy or cholecystectomy or other instrumentation of the bowel < 60 days prior to the Screening Call Prior use of the Study Product MHS-1031 History of any the following diseases that can cause heartburn (ie, "burning feeling behind the breastbone" and/or "pain behind your breastbone" and/or "heartburn" per RESQ-eD question 1, 2, or 3): eosinophilic esophagitis, angina, esophageal spasm, achalasia, rumination, or other conditions involving the mouth, throat, dysphagia, or dyspnea Active history of nicotine use, cannabis use, or alcohol abuse (defined as: > 14 drinks/week or 4 drinks/day for men, 7 drinks/week or 3 drinks/day for women). Has used any tobacco, nicotine, or cannabis products (of any type) in the last 6 months or has abused alcohol in the last 6 months Taking any excluded medications listed in the protocol (eg, metformin, antibiotics within the prior 6 months, and during the study) If female, is pregnant, lactating, or intending to become pregnant before or while participating in this study or intending to donate ova during such time period Use of colon prep or high colonic within 30 days prior to the Screening Call Narcotic (eg, opiate) use within 60 days of the Screening Call Antibiotic use within 60 days of the Screening Call Use of any investigational product within 3 months or five half-lives (whichever is longer) prior to study entry Participation in another investigation (clinical trial) during the course of this study Participation in a rigorous weight loss program or have any planned changes in diet or lifestyle, such as getting married, change in residence, change in job, or other highly stressful event Diagnosis of inflammatory bowel disease, irritable bowel syndrome (IBS-D and IBSC), Chronic Idiopathic Constipation Regular use (ie, >=4 times per month) of antibacterial mouthwash (eg, Listerine, Scope, others) and unwilling to stop use for the duration of the study Subject previously took PPIs daily for heartburn, for at least 7 consecutive days in the past, and experienced no improvement Subject is employed by (or is a relative of an employee) or is involved in any way with Microbiome Health Sciences Other conditions or situations that, in the investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Peter Swann, MD
Organizational Affiliation
Microbiome Health Sciences
Official's Role
Principal Investigator
Facility Information:
Facility Name
Microbiome Health Sciences
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20109
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No

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Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn

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