Remote Ischemic Preconditioning and Acute Kidney Injury in HTX (RIPCAT)
Heart Transplantation
About this trial
This is an interventional treatment trial for Heart Transplantation focused on measuring orthotopic heart transplantation, HTX
Eligibility Criteria
Inclusion Criteria:
- adult patients (>18 years) undergoing HTX
Exclusion Criteria:
- Acute myocardial infarction up to 7 days before surgery
- age younger than 18 years
- pre-existing AKI
- previous kidney transplantation
- chronic kidney disease with a glomerular filtration rate less than 30ml/min
- pregnancy
- peripheral vascular disease affecting the upper limbs
- hepato-renal syndrome
- drug therapy with sulfonamide or nicorandil
Sites / Locations
- University Hospital DuesseldorfRecruiting
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Experimental
Sham RIPC
RIPC
Control patients will be submitted to 3 cycles of sham RIPC. Each cycle of Sham RIPC consists of a pseudo ischemia of the left upper limb caused by inflating a blood pressure cuff to 20mmHg for 5 minutes followed by 5 minutes of reperfusion time.
Patients in the intervention group will be submitted to 3 cycles of RIPC. For each cycle of RIPC, a blood pressure cuff will be inflated at 200mmHg for 5 minutes (or at least 50mmHg above the systolic arterial blood pressure) followed by 5 minutes of reperfusion time.