Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis
Oral Cavity Cancer, Head and Neck Cancers - Tonsils, Esophageal Cancer
About this trial
This is an interventional supportive care trial for Oral Cavity Cancer
Eligibility Criteria
Inclusion Criteria:
- must have signed and dated an IRB approved consent form that conforms to federal and institutional guidelines
- Age >/= 18 years
- Confirmed lip, oral cavity, hard palate, tongue, tonsil, pharyngeal, neck, esophageal, mediastinal, and/or chest wall cancers
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation.
- Men treated or enrolled on this protocol must agree to use adequate contraception prior to the study, for the duration of study participation.
Exclusion Criteria:
- Patients who are not on concurrent chemotherapy and radiation.
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to aloe vera juice.
- Patients with psychiatric illness/social situations that would limit compliance with study requirements.
- Pregnant women or women who are breastfeeding
Sites / Locations
- Thompson Cancer Survival Center Radiation Oncology ServicesRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Experimental
Active Comparator
Cohort 1--Arm 1
Cohort 1--Arm 2
Cohort 2--Arm 1
Cohort 2-- Arm 2
Aloe Vera Juice + Standard of Care Treatments Swish and spit ¼ cup (2 ounces) of 100% aloe vera juice 3 times per day, 7 days per week as first line treatment, standard of care agents added as needed
Standard of Care Treatments Use salt and baking soda rinses, Magic Mouthwash, Carafate, etc.
Aloe Vera Juice + Standard of Care Treatments Drink ¼ cup (2 ounces) of 100% aloe vera juice 3 times per day, 7 days per week as first line treatment, standard of care agents added as needed
Standard of Care Treatments Use salt and baking soda rinses, Magic Mouthwash, Carafate, etc.