How Can we Treat Photophobia in Migraine
Migraine Disorders, Photophobia
About this trial
This is an interventional treatment trial for Migraine Disorders focused on measuring migraine, photophobia, habituation, headache, functional magnetic resonance imaging
Eligibility Criteria
Inclusion Criteria:
Patients:
- Migraine without aura according to the criteria of the International Classification of Headache Disorders (ICHD-3 beta)
- 1-4 days with migraine per month in the preceding last 3 months
- A score between 2 and 6 on a numeric rating scale for the intensity of interictal photophobia (range from 0 to 10 (= max. intensity))
- A score >4 for ictal photophobia
Controls
- No personal or family history of migraine
- A score <2 for photophobia
Exclusion Criteria:
- Current or previous circadian rhythm disorders
- Current or previous major depression
- Current or previous anxiety disorders
- Current or previous medication overuse
- Besides migraine in the patient group, participants should not suffer from any other recurrent headache apart from infrequent tension-type headaches
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Flash first
Dark first
Light exposure (Flash) first, light deprivation (Dark) second: Both interventions (Flash and Dark) are administered for one hour on 7 consecutive days. During the light exposure, participants are seated 120 cm in front of a white curtain that is illuminated by an LED light source. During the light deprivation, participants are seated in the same room used for light exposure, but in complete darkness.
Light deprivation (Dark) first, Light exposure (Flash) second: Both interventions (Flash and Dark) are administered for one hour on 7 consecutive days. During the light exposure, participants are seated 120 cm in front of a white curtain that is illuminated by an LED light source. During the light deprivation, participants are seated in the same room used for light exposure, but in complete darkness.