The Effect on Metabolism, Food Intake and Preferences of a Knockout Gene Variant Involved in Carbohydrate Metabolism
Diabetes Mellitus, Type 2, Metabolic Disease, Sucrose Intolerance Congenital
About this trial
This is an interventional prevention trial for Diabetes Mellitus, Type 2 focused on measuring Inuit, Greenlandic diet, Diabetes, Microbiota, Glucose variability, Food preference, SI
Eligibility Criteria
Inclusion Criteria:
- Homozygous carriers of the c.273_274delAG variant in the SI-gene (cases)
- Homozygous non-carriers of the c.273_274delAG variant in the SI-gene (controls)
Exclusion Criteria:
- Diagnosis of diabetes or pharmacological treatment of diabetes.
- Gastrointestinal diseases such as inflammatory bowel disease, gastrointestinal cancer, and ulcer. Persons with mild gastrointestinal problems are not excluded, e.g. persons with lactose-intolerance who normally do not have any gastrointestinal problems.
- Homozygous carriers of the TBC1D4 risk variant p.Arg684Ter.
- Lack of compliance with the procedures in the study protocol, judged by Investigator.
- For the homozygous carriers of the c.273_274delAG variant: rise in blood glucose in an oral sucrose tolerance test.
Sites / Locations
- Maniitsoq Healthcare Center
- Pikialaarfik, Greenland Institute of Natural Resources
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Traditional Inuit Diet
Western Carbohydrate-Rich Diet
The traditional Inuit diet will consist of local foods, being primarily of animal origin, e.g. fish, marine mammals, caribou, and lamb. The diet will be supplemented with eggs, potatoes, and berries, and/or other foods low in starch and with no sucrose content. The diet will therefore have a high content of fat and protein, a low content of carbohydrate and no content of sucrose. The participants will receive foods that will cover at least 100% of their energy requitement. Each participant will throw a dice in order to randomize the order of which the participants receive the two intervention diets.
The Western diet will have high amounts of grain products, e.g. bread, pasta, rice, as well as fruits and vegetables and some foods with a high sucrose content, e.g. cake and sweet snacks and/or drinks, and cereal products with added sucrose. The diet will have a low amount of meat. Hence, the diet will be high in carbohydrates, starch, and some sucrose and have a lower content of protein and fat. The participants will receive foods that will cover at least 100% of their energy requitement. Each participant will throw a dice in order to randomize the order of which the participants receive the two intervention diets.