Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy (OXYASP)
Antisocial Personality Disorder
About this trial
This is an interventional other trial for Antisocial Personality Disorder focused on measuring Oxytocin; Psychopathy; Violent Offenders; Social Processing
Eligibility Criteria
Inclusion Criteria:
- Male
- Aged 18-60
- IQ greater than 70 as defined by the Wechsler Abbreviated Scale of Intelligence (WASI-II).
Violent offenders:
Offenders with convictions for violent crimes (murder, rape, attempted murder, grievous and actual bodily harm) who met DSM-5 criteria for antisocial personality disorder (Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5 PD) Psychopathy or non-psychopathy subgroup based on Psychopathy Checklist- Revised (PCL-R; (Hare, 2003))- score of 25 as the threshold for psychopathy in this English population.
Healthy non-offenders:
Non-offenders with no personality disorder
Exclusion criteria:
- history of major mental disorders (bipolar 1, bipolar 2, major depression or psychotic disorders)
- self-reported neurological disorders
- head injury resulting in loss of consciousness for 1 hour or longer
- severe visual or hearing impairments
- contraindications to MRI
Sites / Locations
- Insititue of Psychiarty, Psychology and Neuroscience
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
Violent offenders with psychopathy
Violent offenders without psychopathy
Healthy non-offenders
Violent offenders with psychopathy
Violent offenders without psychopathy
Healthy non-offenders