Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty (SUPER-DMEK)
Fuchs' Endothelial Dystrophy
About this trial
This is an interventional treatment trial for Fuchs' Endothelial Dystrophy focused on measuring Fuchs' endothelial corneal dystrophy, Descemet membrane endothelial keratoplasty, Incomplete graft attachment, Endothelial corneal graft detachment, Rebubbling (repeat injection of air or gas in the anterior chamber), Supine positioning, Postoperative posture, Anterior segment optical coherence tomography, Neural network, Machine learning, Randomized controlled trial
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of advanced Fuchs' endothelial corneal dystrophy (FECD)
- Indication for corneal endothelial transplantation (Descemet Membrane Endothelial Keratoplasty - DMEK)
Exclusion Criteria:
- Other corneal diseases (i.e. corneal scars, corneal dystrophies except FECD, corneal inflammation / infection)
- Regular use of drugs potentially affecting the cornea (i.e. amiodarone, chloroquine, triptan, isotretinoin, use of contact lenses in past four weeks, anesthetic eye drops)
- Diabetes mellitus with endorgan complications)
- Lack of fixation during corneal tomography
- Bedridden
Sites / Locations
- Medical Center - University of Freiburg, Eye Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
5 days supine positioning
1 day supine positioning followed by usual physical activity for 4 days
Supine positioning for 5 days after DMEK with upright positioning for only 10 min every hour.
Supine positioning for 1 days after DMEK with upright positioning for only 10 min every hour.