Dual-light Antibacterial Photodynamic Therapy as an Adjunctive Treatment to Corticosteroid Treatment in OLP (RELIEF-OLP)
Oral Lichen Planus, Dental Plaque, Oral Bacterial Infection
About this trial
This is an interventional supportive care trial for Oral Lichen Planus focused on measuring Lumoral, Lumorinse, Plaque, Oral Lichen Planus, aMMP-8, aPDT, Pain score (VAS)
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed diagnosis of OLP with bilateral symmetrical lesions and gingival involvement
- Age >18 years
- Able to provide a written consent
- Willing and able to complete questionnaires
- Able to co-operate with the treatment protocol and avoid any other oral hygiene measures outside of the study protocol
Exclusion Criteria:
- Lichenoid lesions suspected to be induced by contact allergy or drugs
- Any treatment for OLP in two weeks prior to the study/ a history of topical therapy for OLP in the past 2 weeks or systemic therapy in the past 4 weeks;
- Pregnant or lactating
- Photosensitivity
- Use of antibiotics within 2 weeks prior the study
Sites / Locations
- Tampere University Hospital, Oral and maxillofacial diseases
- Wellbeing services County Pirkanmaa, Health Services, Orthodontics and specialized dental careRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Study group
Control group
Subjects in the study group will use the Lumoral device five to seven times a week according to the verbal and written instructions provided to them. In addition, they will brush their teeth twice daily in their customary manner while using the provided sonic toothbrush and regular toothpaste.
Subjects in the control group will brush their teeth in their customary manner twice daily while using the provided sonic toothbrush and regular toothpaste. They will not receive any additional intervention.