The Adjunctive Effect of Soft Tissue Augmentation Procedures of Moderate-severe Peri-implantitis
Peri-Implantitis
About this trial
This is an interventional treatment trial for Peri-Implantitis focused on measuring tissue augmentation of moderate-severe peri-implantitis, implantoplasty, collagen matrix, autogenous connective tissue graft
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years old (UZH, FRA) or > 21 years old (SIN), male and female.
Diagnosed with periimplantitis of at least 1 implant in function for at least 1 year Diagnostic criteria
- Presence of bleeding and/or suppuration on gentle probing.
- Probing depths of ≥6 mm.
- Bone levels ≥3 mm apical of the most coronal portion of the intraosseous part of the implant.
- Periodontal health (including previously treated periodontitis patients with reduced but healthy periodontium)
- Good oral hygiene (full mouth plaque score <25%)
- Adequate control of inflammation (full mouth BOP <25%)
- Signed informed consent form
Exclusion Criteria:
- Pregnant or lactating female patient at inclusion
- Allergy or objection to porcine and bovine implantable biomaterials
- Allergy to Penicillin or NSAIDs
- Known or suspected non-compliance, drug or alcohol abuse
- Inability to follow the procedures of the study, e.g. due to language/ comprehension problems, psychological disorders, dementia, etc. of the participant
- Smoking > 15 cigarettes a day
- Active periodontal disease
Sites / Locations
- Department of Oral Surgery and Implantology, Centre for Dentistry and Oral Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt
- National Dental Centre Singapore
- Clinic of Reconstructive Dentistry, Center of Dental Medicine University of ZurichRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
Subepithelial connective tissue group (SCTG)
Volume stable Collagen Matrix group (VCMX)
No soft tissue augmentation (GBR)
A SCTG will be harvested from the patient's palate with a dimension dependent on the size of the peri-implant osseous defect. The technique of harvesting a soft tissue grafting is well described and established in the literature. Following the administration of local anesthesia, the SCTG will be harvested using a single incision technique. The periosteum will be left intact. The thickness of the SCTG will be at least 1.5mm. A cross suture will be used to close the palatal incision. The SCTG will be placed on the buccal exposed implant threads (above the DBBM-C) exceeding 1mm in a coronal and apical direction, 3mm in a mesial and distal direction and then immobilized using a horizontal mattress connecting it to the lingual or palatal flap. The flaps are then closed primarily and tension-free following a horizontal periosteal releasing incision.
A VMCX (FibroGide®) will be hydrated in sterile saline, trimmed and adjusted to a dimension dependent on the size of the osseous peri-implant defect. The VCMX will then be placed as described above and then immobilized using a horizontal mattress connecting it to the lingual or palatal flap. The flaps are then closed primarily and tension-free following a horizontal periosteal releasing incision.
No barrier membranes will be placed. After filling the defect with the bone substitute, the flaps are closed primarily and tension-free following a horizontal periosteal releasing incision.