Alcohol and Breast Cancer (ABC) Trial
ER+ Breast Cancer, Breast Cancer, Aromatase Inhibitors
About this trial
This is an interventional basic science trial for ER+ Breast Cancer focused on measuring ER+ Breast Cancer, Breast Cancer, Aromatase Inhibitors, Anastrozole, Letrozole, Exemestane
Eligibility Criteria
Inclusion Criteria:
- ER+ breast cancer
- Female sex at birth
- Postmenopausal, either natural or induced
- Self-reported consumption of at least one alcoholic drink per week but not more than one serving per day
- Currently prescribed aromatase inhibitors including anastrozole (Arimidex®), letrozole (Femara®), and exemestane (Aromasin®)
- Documented liver function test results below 1.5X the upper limit of normal within 12 months of screening
Exclusion Criteria:
- Self-reported consumption of more than one drink per day, a previous or current history of alcohol abuse based on standard questionnaires (AUDIT≥8), or consumption of more than 4 or more drinks in one day within the last 6 months
- Currently undergoing cytotoxic chemotherapy or radiation or planned in the next two months
- Any surgery planned in the next two months
- Alcohol flushing syndrome
- Current use of any pharmaceutical agent contraindicated with alcohol, including warfarin, dual antiplatelet therapy, and metronidazole
- Hemoglobin A1c>8% or a fasting glucose result above 180 mg/dL within 6 months of screening
- Unable to speak or understand English
- Unable to understand and provide informed consent, as judged by the study team
Sites / Locations
- Beth Israel Deaconess Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
WHITE WINE FOLLOWED BY WHITE GRAPE JUICE
WHITE GRAPE JUICE FOLLOWED BY WHITE WINE
Participants will be randomized into one of the study drinking sequence groups: white wine followed by white grape juice or white grape juice followed by white wine. The research study procedures include one screening visit to obtain informed consent, four study visits with blood draws, and ten weekly phone calls and online questionnaires over the ten weeks of the study. -3 weeks of daily white wine followed by 3 weeks of daily white grape juice
Participants will be randomized into one of the study drinking sequence groups: white grape juice followed by white wine. The research study procedures include one screening visit to obtain informed consent, four study visits with blood draws, and ten weekly phone calls and online questionnaires over the ten weeks of the study. - 3 weeks of daily white grape juice followed by 3 weeks of daily white wine