Glucose Control Using Continuous Glucose Monitoring in People With Type 2 Diabetes Who Have Had Acute Myocardial Infarct (GLAM)
Type 2 Diabetes, Acute Myocardial Infarction, Acute Myocardial Infarction With ST Elevation
About this trial
This is an interventional treatment trial for Type 2 Diabetes
Eligibility Criteria
Inclusion Criteria:
From the Hammersmith Hospital In-patient Cardiology Services:
- Adults aged >18 years
- Known type 2 diabetes
- Taking one or more oral hypoglycaemic agent, GLP1 receptor analogue and/or insulin
- HbA1c >58mmol/mol
- Admitted to the HAC with ACS
- Raised blood troponin level on admission
From Imperial College Healthcare Trust Diabetes and Cardiology Clinics:
Adults aged >18 years
- Known type 2 diabetes
- Previous acute coronary syndrome within the last 10 years but > 6 months ago
- Taking one or more oral hypoglycaemic agent and /or GLP1 receptor analogue, and/or insulin
- HbA1c >58mmol/mol
Exclusion Criteria:
From the Hammersmith Hospital In-patient Cardiology Services:
- Acute coronary syndrome within the last 6 months
- People who have previously had bariatric surgery
- People taking hydroxyurea
- People who undergo haemodialysis or peritoneal dialysis
- Unable to participate due to other factors, as assessed by the Chief Investigators
- Pregnancy as determined by clinical team
- Known to have a terminal condition or conditions that suggest a life expectancy less than 1 year
From Imperial College Healthcare Trust Diabetes and Cardiology Clinics:
- People who have previously had bariatric surgery
- People taking hydroxyurea
- People who undergo haemodialysis or peritoneal dialysis
- Unable to participate due to other factors, as assessed by the Chief Investigators
- Pregnancy as determined by clinical team
- Known to have a terminal condition or conditions that suggest a life expectancy less than 1 year
- Previous acute coronary syndrome more than 10 years ago or within the last 6 months
Sites / Locations
- Hammersmith Hospital inpatient cardiology servicesRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
No Intervention
No Intervention
No Intervention
Real time CGM post acute myocardial infarct
Blinded CGM post acute myocardial infarct
Blinded CGM historical acute myocardial infarct (>6 months and <10 years ago)
Cardiovascular outcomes control group
Real time Dexcom ONE CGM system to be applied for 26 weeks post acute myocardial infarct.
Blinded Dexcom ONE CGM system to be applied for 10 days at recruitment, and then at days 17-23, week 10 and week 24. This will be for the purposes of monitoring glucose only and is not an intervention and is blinded to the participants and the study investigators. CGM measurements will be blinded until the end of the study. Management of diabetes in this cohort as per usual standards of care.
Blinded Dexcom ONE CGM system to be applied for 10 days at recruitment. This will be for the purposes of monitoring glucose only and is not an intervention and is blinded to the participants and the study investigators. Management of diabetes in this cohort as per usual standards of care.
Age and sex-matched controls from the NIHR Cardiovascular Health Informatics Collaborative.