The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients
Remimazolam
About this trial
This is an interventional other trial for Remimazolam
Eligibility Criteria
Inclusion Criteria:
- The adult patients who are scheduled to surgery under general anesthesia
Exclusion Criteria:
- Severe obesity (BMI > 30 kg/m2)
- Allergy to remimazolam or remifentanil
- Under conditions which make it difficult to respond to the investigator's verbal commends like hearing impairment, etc.
- Patients with general conditions are more than ASA class III
- Patients with brain disease (dementia, cerebral infarction, etc.)
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
remifentanil group
control group
Start the continuous infusion of 25cc of remifantanil (labeled as a test drug) by TCI mode ( the target effect site concentration is 2.0). While slowly injecting the prescribed dose of remimazolam over 30 seconds, observe whether it responds to the investigator's oral commands and the disappearance of the eyelash reflex for 3 minutes after administering the drug. Success in inducing loss of consciousness during anesthesia is defined as the loss of both verbal command response and eyelash reflex within 3 minutes after infusion, otherwise it is considered a failure. The dose of remimazolam is initially 0.15 mg/kg and the next experimental dose is determined according to the biased coin design up-and-down sequential method. The standard deviation of this study is 0.05 mg.
Start the continuous infusion of 25cc of normal saline (labeled as a test drug). While slowly injecting the prescribed dose of remimazolam over 30 seconds, observe whether it responds to the investigator's oral commands and the disappearance of the eyelash reflex for 3 minutes after administering the drug. Success in inducing loss of consciousness during anesthesia is defined as the loss of both verbal command response and eyelash reflex within 3 minutes after infusion, otherwise it is considered a failure. The dose of remimazolam is initially 0.15 mg/kg and the next experimental dose is determined according to the biased coin design up-and-down sequential method. The standard deviation of this study is 0.05 mg.