Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis
Periodontitis Stage I, Periodontal Diseases, Periodontal Inflammation
About this trial
This is an interventional treatment trial for Periodontitis Stage I
Eligibility Criteria
Inclusion Criteria:
- patients with gingivitis or stage I/II periodontits. The presence of gingivitis and the presence/severity of periodontitis is registered using the American Academy of Periodontology 2017 workshop published definition With this method, patient was identified affected by periodontits when ''Interdental CAL is detectable at ≥2 non-adjacent teeth, or Buccal/oral CAL ≥3 mm with pocketing >3 mm is detectable at ≥2 teeth'' (Toentti et al, 2018) with grade I severity being cases with interdental CAL from 1-2mm and grade II severity being cases with interdental CAL from 3-4 mm
Exclusion Criteria:
- Patients incapable of giving informed consent
- Patients unable to attend the 3-month follow-up
- Patients with interdental CAL >4mm
- Patient requiring surgical periodontal treatment
- Patients on systemically administered vitamin B or vitamin B-complex
- Patients undergoing chemo- or immunosuppressive therapy over the previous 5 years
- Patients treated or undergoing treatment with intravenous amino-bisphosphonates
- Patients with poor oral motivation
- Substance abusers
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
vitamin B3
Vitamin B-9
Placebo capsule
Vitamin B-3 capsule consists of Manufacturer: DSM Nutritional products Ltd generic name: nicotine amide Constituent components: 100mg of nicotine amide Route of administration: orally dosing schedule:1capsule/day/ before meal duration: for 30 days
Vitamin B-9 capsule Manufacturer: Hebei Jiheng pharmaceutical Co. Ltd generic name: folic acid. Constituent components: 5 mg of folic acid. Route of administration: orally dosing schedule: 1capsule/day/before meal duration: for 30 days
Placebo capsule Manufacturer: Shivangan Foods & Pharma Products Pvt. Ltd Constituent components: inactive fillers Route of administration: orally dosing schedule: 1capsule/day/before meal duration: for 30 days