Laser Therapy Effect on Oral Mucositis in Childhood Acute Lymphoblastic Leukemia Patients
Oral Mucositis, Childhood Acute Lymphoblastic Leukemia
About this trial
This is an interventional supportive care trial for Oral Mucositis focused on measuring Oral Mucositis, Childhood Acute Lymphoblastic Leukemia, Laser therapy, low level laser therapy
Eligibility Criteria
Inclusion Criteria:
- Patients with Acute Lymphoblastic Leukemia in the induction therapy phase and have oral mucositis grade 2 or more.
- Age: 3-14 years old of both genders.
- No previous treatment with laser.
- Ability to open mouth for more than 2 cm for the duration of laser application with a level of cooperation (Frankl rating 3 or 4).
- Patients who still have 10 days in their induction therapy phase or can be followed up for a mininum of 10 days after the development of oral mucositis
Exclusion Criteria:
- Patients receiving radiotherapy
- Received oral Cryotherapy or IV keratinocyte growth factor for oral mucositis
- Patients with unstable clinical condition (e.g. sepsis)
- Patients who will be withdrawn from participation according to their request or due to loss in follow up
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
Group I
Group II
Group III
Seventeen patients will receive treatment using the red wavelength (660 nm) to provide biostimulation. Plus the current protocol (antifungal +/- antiviral and analgesics) used by CCHE which will be recorded in the patient's file.
Seventeen patients will receive treatment using the infrared wavelength (970 nm) to provide biosstimulation. plus the current protocol(antifungal +/- antiviral and analgesics) used by CCHE which will be recorded in the patient's file.
Seventeen patients will receive mock treatment which is the exact repetition of the treatment modality but without any laser emission plus the current protocol(antifungal +/- antiviral and analgesics) used by CCHE which will be recorded in the patient's file