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Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia

Primary Purpose

Aphasia

Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
tDCS stimulation
Sponsored by
The University of Hong Kong
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Aphasia focused on measuring tDCS, Aphasia, naming

Eligibility Criteria

40 Years - 90 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • People with chronic aphasia following the stroke

Exclusion Criteria:

  • history of seizure or epilepsy,
  • previous adverse reactions to TMS/tDCS,
  • having a pace-maker or a metal implanted in the brain
  • being pregnant

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Active Comparator

    Sham Comparator

    Arm Label

    anodal tDCS

    sham tDCS

    Arm Description

    20 minutes of one mA anodal High-Definition tDCS (HD-tDCS) over right IFG combined with 40 minutes of naming therapy for five consecutive days in week 1

    20-minutes sham HD-tDCS with 40-minutes therapy of naming therapy for five consecutive days in week 1

    Outcomes

    Primary Outcome Measures

    Picture naming task
    One hundred and sixty pictures of concrete nouns from the Snodgrass and Vanderwart (1980) picture set (colored version) were utilised to measure the percentage of object naming accuracy. In particular, these pictures were divided into Set A (training targets) and Set B (untrained generalization targets), with eighty stimuli in each set.

    Secondary Outcome Measures

    language task
    * Overall language skills are measured through the overall aphasia scores provided by the Cantonese version of Western Aphasia Battery (short-form). The scale is called Aphasia quotient: Minimum value = 0, maximum value = 100, with higher scores mean a better performance.
    Cognitive task
    The cognitive skills are measured through the subtest scores provided by Oxford Cognitive Screening-Cantonese. The test uses different sub-tests including the Picture naming, Semantics, Orientation, Visual field task, Sentence reading , Calculation, Attention, Praxis, Memory, and Executive tasks. The range of values varies across the subtests. For all subtests except the executive task, the higher scores reflect better performance. For executive tasks the lower scores reflect better performance.

    Full Information

    First Posted
    July 18, 2022
    Last Updated
    November 1, 2022
    Sponsor
    The University of Hong Kong
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    1. Study Identification

    Unique Protocol Identification Number
    NCT05471570
    Brief Title
    Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia
    Official Title
    The Effect of tDCS Stimulation of Right Inferior Frontal Gyrus on Language Recovery in Speakers With Aphasia
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    November 2022
    Overall Recruitment Status
    Completed
    Study Start Date
    January 1, 2017 (Actual)
    Primary Completion Date
    November 1, 2017 (Actual)
    Study Completion Date
    December 20, 2017 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    The University of Hong Kong

    4. Oversight

    Studies a U.S. FDA-regulated Drug Product
    No
    Studies a U.S. FDA-regulated Device Product
    No

    5. Study Description

    Brief Summary
    There are two opposing hypotheses, namely the interference and laterality-shift hypotheses, regarding the role of the right hemisphere (RH) in language recovery following a left hemisphere damage. Transcranial direct current stimulation (tDCS) has received increasing attention as a potential complement to behavioural therapy. This preliminary study aimed to examine the effect of excitatory (anodal) stimulation of right inferior frontal gyrus (IFG) on naming abilities of chronic people with aphasia (PWA) to examine the compensatory versus interference role of RH in language recovery, and to confirm the application of tDCS does not induce adverse effects on other cognitive and language functions.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Aphasia
    Keywords
    tDCS, Aphasia, naming

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Not Applicable
    Interventional Study Model
    Crossover Assignment
    Masking
    ParticipantCare ProviderOutcomes Assessor
    Allocation
    Randomized
    Enrollment
    4 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    anodal tDCS
    Arm Type
    Active Comparator
    Arm Description
    20 minutes of one mA anodal High-Definition tDCS (HD-tDCS) over right IFG combined with 40 minutes of naming therapy for five consecutive days in week 1
    Arm Title
    sham tDCS
    Arm Type
    Sham Comparator
    Arm Description
    20-minutes sham HD-tDCS with 40-minutes therapy of naming therapy for five consecutive days in week 1
    Intervention Type
    Device
    Intervention Name(s)
    tDCS stimulation
    Other Intervention Name(s)
    language therapy
    Intervention Description
    The study examines the effect of excitatory stimulation of right inferior frontal gyrus (IFG) on naming abilities of people with aphasia (PWA) as compared to sham stimulation to examine the compensatory versus interference role of right hemisphere in language recovery after stroke.
    Primary Outcome Measure Information:
    Title
    Picture naming task
    Description
    One hundred and sixty pictures of concrete nouns from the Snodgrass and Vanderwart (1980) picture set (colored version) were utilised to measure the percentage of object naming accuracy. In particular, these pictures were divided into Set A (training targets) and Set B (untrained generalization targets), with eighty stimuli in each set.
    Time Frame
    Immediately after the end of each treatment session and block
    Secondary Outcome Measure Information:
    Title
    language task
    Description
    * Overall language skills are measured through the overall aphasia scores provided by the Cantonese version of Western Aphasia Battery (short-form). The scale is called Aphasia quotient: Minimum value = 0, maximum value = 100, with higher scores mean a better performance.
    Time Frame
    Immediately after the end of each treatment block
    Title
    Cognitive task
    Description
    The cognitive skills are measured through the subtest scores provided by Oxford Cognitive Screening-Cantonese. The test uses different sub-tests including the Picture naming, Semantics, Orientation, Visual field task, Sentence reading , Calculation, Attention, Praxis, Memory, and Executive tasks. The range of values varies across the subtests. For all subtests except the executive task, the higher scores reflect better performance. For executive tasks the lower scores reflect better performance.
    Time Frame
    Immediately after the end of each treatment block

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    40 Years
    Maximum Age & Unit of Time
    90 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: People with chronic aphasia following the stroke Exclusion Criteria: history of seizure or epilepsy, previous adverse reactions to TMS/tDCS, having a pace-maker or a metal implanted in the brain being pregnant

    12. IPD Sharing Statement

    Plan to Share IPD
    No

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    Effect of Anodal Transcranial Direct Current Stimulation (tDCS) Over the Right-hemisphere on Picture Naming in Chronic Aphasia

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