Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients With Gastrointestinal Tumor (TEAS)
Postoperative Cognitive Dysfunction
About this trial
This is an interventional prevention trial for Postoperative Cognitive Dysfunction
Eligibility Criteria
Inclusion Criteria:
Patients aged 60 years or older.
Patients diagnosed with gastrointestinal tumor and received radical resection of gastrointestinal tumors under general anesthesia in Subei People's Hospital of Jiangsu province.
Patients willing and able to give informed consent and comply with this study protocol.
- American Society of Anesthesiology (ASA) classification I~III. ⑤ Preoperative Tilburg frailty scale score is less than 5 points. ⑥ Preoperative D-dimer was normal.
Exclusion Criteria:
Preoperative cognitive dysfunction or history of cognitive dysfunction, dementia, and delirium.
History of severe depression, schizophrenia, or other mental and nervous system diseases or taking antipsychotic or antidepressant drugs in the past.
Patients with severe hearing or visual impairment without assistive tools.
Patients who have difficulty in communicating.
Male patients average daily pure alcohol intake ≥ 61 g or female patients average daily pure alcohol intake ≥ 41 g.
Patients received surgical treatment within 3 months or preoperative hospitalized over 3 months.
Patients with severe heart, liver, or renal failure.
⑧ Patients with hypoxemia (blood oxygen saturation < 94%) more than 10 min during the operation.
⑨ Patients admitted to ICU after operation.
⑩ Patients who quit or died due to noncooperation or sudden situation.
⑪ Patients who already participate in other clinical studies which may influence this study.
⑫ Patients who underwent emergency surgery.
⑬ Patients who had a history of acupuncture treatment.
Sites / Locations
- Northern Jiangsu People's Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Experimental
Experimental
Experimental
Experimental
Experimental
Sham Comparator
No Intervention
preoperative TEAS group
Intraoperative TEAS group
Postoperative TEAS group
Pre-and post-operative TEAS group
Perioperative TEAS group
Sham TEAS group
Control group
Receive a TEAS on bilateral Neiguan (PC6) Yintang (GV29) and Zusanli (ST36) by the transcutaneous electrical stimulators to provide an altered frequency 2/100 Hz, disperse-dense waves, and adjusted intensity which was less than 10 mA, 30 min before anesthesia.
Receive a TEAS on bilateral Neiguan (PC6) Yintang (GV29) and Zusanli (ST36) by the transcutaneous electrical stimulators to provide an altered frequency 2/100 Hz, disperse-dense waves, and adjusted intensity which was less than 10 mA, from 30 min before anesthesia to the end of surgery
Receive a TEAS on bilateral Neiguan (PC6) Yintang (GV29) and Zusanli (ST36) by the transcutaneous electrical stimulators to provide an altered frequency 2/100 Hz, disperse-dense waves, and adjusted intensity which was less than 10 mA, once a day, 30 minutes each time for 7 consecutive days after operation
Receive a TEAS on bilateral Neiguan (PC6) Yintang (GV29) and Zusanli (ST36) by the transcutaneous electrical stimulators to provide an altered frequency 2/100 Hz, disperse-dense waves, and adjusted intensity which was less than 10 mA, from 1 day before operation to 7 days after operation, once a day, 30 minutes each time.
Receive a TEAS on bilateral Neiguan (PC6) Yintang (GV29) and Zusanli (ST36) by the transcutaneous electrical stimulators to provide an altered frequency 2/100 Hz, disperse-dense waves, and adjusted intensity which was less than 10 mA, 30 min before the induction of anesthesia to the end of the surgery, 1 day before operation, and on the 1st, 2nd and 3rd days after surgery, 30 min once a day.
the electrodes were placed at the same time as the perioperative TEAS group, but the electronic stimulation was not applied and they were told that the TEAS treatment have no feeling
receive standardised perioperative management such as preoperative health education, optimize anaesthesia scheme, intraoperative heat preservation, and reduce surgical trauma.