High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study (HIPPOS)
Cardiac Conduction System, His Bundle Pacing, Heart Failure
About this trial
This is an interventional treatment trial for Cardiac Conduction System focused on measuring His bundle pacing, conduction system pacing, Heart failure, Cardiomyopathy, narrow QRS, Ejection Fraction
Eligibility Criteria
Inclusion Criteria:
- Aged 18 or above
- Ventricular Ejection Fraction (EF) < 50%; BNP needs to be ≥250ng/L or N Terminal-pro BNP≥600ng/L for patients with EF 36-50% and they should have an ICD indication
- New York Heart Association (NYHA) class I-IV
- Narrow QRS duration (≤110ms) on 12 lead ECG
Exclusion Criteria:
- Other serious medical condition with life expectancy of less than 1 year
- Lack of capacity to consent
- Pregnancy
Sites / Locations
- Miulli General HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
High intensity His bundle pacing
Back up only ventricular pacing
After implantation of the device there will be a 1-month run-in period that the device will be programmed to deliver His bundle pacing therapy during this period at 3.5V/1msec. After one month these patients will continue to receive active pacing treatment with 3.5V/1msec.
After implantation of the device there will be a 1-month run-in period that the device will be programmed to deliver His bundle pacing therapy during this period at 2V/1msec. After one month these patients will receive back up only pacing (pacemaker programmed to VVI 30 bpm or AAI(R)-DDD(R) 50bpm) for 6 months.