A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore
Endometrial Hyperplasia, Fertility Issues, Disease Regression
About this trial
This is an interventional treatment trial for Endometrial Hyperplasia focused on measuring Endometrial Hyperplasia, Fertility, Disease Regression, Randomised Clinical Trial, Mirena IUS, Megace
Eligibility Criteria
Inclusion Criteria:
- All women diagnosed with atypical hyperplasia aged 21 years to 40 years
- Keen for fertility-preserving treatment
Exclusion Criteria:
- Patients who are currently undergoing treatment for atypical hyperplasia
- Patients with a history of endometrial carcinoma
Sites / Locations
- National University HospitalRecruiting
- Singapore General HospitalRecruiting
- KK Women's and Children's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Mirena Arm
Megace Arm
The patients in the Mirena arm will have a Mirena inserted at time of recruitment of the study. An endometrial biopsy will be performed to assess for disease progression, regression or persistence after 3 months. The endometrial biopsy will be performed via bedside endometrial sampling or hysteroscopic biopsy. As Mirena can be used for treatment of atypical hyperplasia as well as endometrial protection (decreases the risk of endometrial hyperplasia recurrence), the option of keeping or changing the Mirena during biopsy will be discussed with the patient.
The patients in the megace arm will have be prescribed 3 months of oral megace at time of recruitment of the study. An endometrial biopsy will be performed to assess for disease progression, regression or persistence after 3 months. The endometrial biopsy will be performed via bedside endometrial sampling or hysteroscopic biopsy.