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HAIC Combined With Donafenib Tosilate and Toripalimab for Unresectable HCC

Primary Purpose

Hepatocellular Carcinoma

Status
Not yet recruiting
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
HAIC(FOLFOX)
Oxaliplatin
Leucovorin
Fluorouracil
Toripalimab
Donafenib
Sponsored by
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Hepatocellular Carcinoma focused on measuring HCC

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Signed an informed consent form, abled to comply with visits and related procedures specified in the program;
  • Age 18-75 years old (including the boundary value), male or female;
  • Zubrod-ECOG-WHO scored 0 to 1;
  • Expected survival time ≥ 12 weeks;
  • Serum AFP detection and imaging examination meet the clinical diagnostic criteria for hepatocellular carcinoma in the "National Health Commission of the People's Republic of China. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)";
  • Liver function grading: Child-Pugh grade A or better B grade (≤7 points);
  • According to the modified solid tumor efficacy evaluation criteria (mRECIST), at least one imaging measurable lesion;
  • Newly diagnosed hepatocellular carcinoma patients who have not undergone any local or systematic treatment for hepatocellular carcinoma in the past;
  • Patients with hepatocellular carcinoma who have been evaluated by researchers and do not have the conditions for radical resection surgery, but are expected to achieve radical resection through translational therapy, include but are not limited to one of the following situations:

    1. The tumor is massive, close to or involves the main intrahepatic ducts, and the surgical margin is expected to be 1 cm or closer to the edge of the tumor, making it difficult to achieve R0 resection;
    2. The tumor is large, but limited to the target resection of the liver segment;
    3. Tumors with large vascular carcinoma suppositories, such as portal vein primary branch carcinoma suppositories (not entering the main trunk), hepatic vein cancer suppositories (not entering the inferior vena cava), but portal vein cancer embolus can only be limited to one side and cannot affect the contralateral side;
    4. Tumor nodules ≥ 4, and mainly concentrated on the side of the liver;
    5. other conditions in which the researcher believes that radical resection may be achieved through translational therapy;
  • Full organ and bone marrow function, and the laboratory test values within 7 days before enrollment meet the following requirements (no blood components, cell growth factors, albumin, and other drugs for corrective treatment are allowed within the first 14 days of obtaining laboratory tests), as follows:

    1. Blood count: absolute neutrophil count (ANC) ≥ 1.5×10^9/L; Platelet count (PLT) ≥75×10^9/L; Hemoglobin content (hemoglobin, HGB) ≥80g/L;
    2. Liver function: serum total bilirubin (TBIL) ≤ 1.5× upper limit of normal value (ULN); Alanine aminotransferase (ALT) and aspartate aminotransase (AST) ≤5×ULN; Serum albumin ≥ 28 g/L; alkaline phosphatase (ALP) ≤5×ULN;
    3. Renal function: serum creatinine (creatinine, Cr) ≤ 1.5× ULN or clearance of creatinine (CCr) ≥ 45mL/min (Cockcroft-Gault formula); Urinalysis results show urine protein <2+;
    4. Coagulation function: the international normalized ratio (INR) is ≤2, and the activated partial thromboplastin time (APTT) ≤ 1.5 times ULS;
    5. Normal thyroid function, defined as thyroid-stimulating hormone (TSH) in the normal range. If the baseline TSH is outside the normal range, subjects with total T3 (or FT3) and FT4 within the normal range can also be enrolled;
    6. Myocardial enzyme profile is within the normal range (if the researcher comprehensively judges that it is not clinically significant as a simple laboratory abnormality, it is also allowed to enroll);
  • Female subjects of childbearing age should undergo a negative urine or serum pregnancy test within 7 days prior to receiving the first study drug administration (day 1 of the first cycle). If the results of the urine pregnancy test cannot be confirmed as negative, a blood pregnancy test is required. Women of non-reproductive age are defined as at least 1 year after menopause, or have undergone surgical sterilization or hysterectomy;
  • If there is a risk of conception, all subjects (whether male or female) should use contraception with an annual failure rate of less than 1% throughout the treatment period until 120 days after the last study drug administration of treatment.

Exclusion Criteria:

  • Histology contains fibroblast hepatocellular carcinoma, sarcoma-like hepatocellular carcinoma, cholangiocarcinoma and other components;
  • Patients with hepatocellular carcinoma who have previously undergone radical resection and recurrent hepatic cancer;
  • Have received liver transplantation in the past;
  • Have previously received systemic therapy for hepatocellular carcinoma, including targeted drug therapy such as sorafenib, renvatinib, and rigofenib, or immunomodulatory agent therapy such as anti-PD-1, anti-PD-L1/L2, and anti-CTLA-4, excluding antiviral therapy; If the patient has previously used Chinese medicine with anti-tumor indications, he or she must be > 2 weeks or 5 drug half-lives (whichever is longer) after the completion of treatment and before the use of this study;
  • Before starting treatment, there has not been sufficient recovery from toxicity and / or complications caused by any intervention (i.e., ≤ grade 1 or reach baseline, excluding fatigue or hair loss);
  • Patients with any extrahepatic organ or lymph node metastases, including but not limited to: lung metastases, bone metastases, brain metastases or local lymph node metastases;
  • There are tumors in the left and right liver lobes, such as diffuse multiple tumors of the whole liver, tumor infiltration of contralateral phylloscopic vein branches, and concomitant inferior vena cava cancer suppositories, etc. There is no potential possibility of transformable resection;
  • There is difficult to control hepatic encephalopathy, hepatorenal syndrome, ascites, pleural effusion or pericardial effusion;
  • Active bleeding or coagulation abnormalities, bleeding tendencies, or receiving thrombolytic, anticoagulant, or antiplatelet therapy;
  • Major surgical procedures (craniotomy, thoracic or abdominal opening) or unhealed wounds, ulcers, or fractures that have not healed within 4 weeks prior to the first dose. Tissue aspiration biopsy or other minor surgical procedures within 7 days prior to the first administration, with the exception of a venipuncture catheter for the purpose of intravenous infusion;
  • History of gastrointestinal bleeding within the previous 4 weeks or a clear tendency to bleed from the gastrointestinal tract (e.g., known focal active ulcer lesions, fecal occult blood++, gastroscopy if persistent fecal occult blood +), or other conditions determined by the researcher that may cause gastrointestinal bleeding (e.g., severe floor/esophageal varices);
  • History of any arteriovenous thrombosis, embolism or ischemia in the previous 6 months, such as myocardial infarction, unstable angina, deep vein thrombosis, pulmonary embolism, cerebrovascular accident or transient ischemic attack;
  • History of gastrointestinal perforation, abdominal fistula or abdominal abscess within the previous 6 months;
  • Patients with past and current objective evidence of a history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, and severe impairment of lung function;
  • Previously or currently suffering from congenital or acquired immunodeficiency diseases;
  • Active autoimmune diseases requiring systemic therapy or a history of the disease within the previous 2 years (vitiligo, psoriasis, alopecia, or Grave's disease that do not require systemic treatment within the last 2 years, hypothyroidism requiring thyroid hormone replacement therapy only, and patients with type I diabetes who require only insulin replacement therapy can be selected). Known history of primary immunodeficiency. Only patients with positive autoimmune antibodies need to be confirmed as to whether an autoimmune disease is present according to the investigator's judgment;
  • Immunosuppressive drugs have been used within the previous 4 weeks, excluding nasal spray, inhalation or other routes of local glucocorticoids or physiological doses of systemic glucocorticoids (i.e., not more than 10 mg/day prednisone or equivalent doses of other glucocorticoids), allowing the temporary use of glucocorticoids for the treatment of symptoms of dyspnea in the treatment of asthma, chronic obstructive pulmonary disease and other diseases;
  • Attenuated live vaccines were received within the previous 4 weeks or planned for the duration of the study;
  • Other malignancies are diagnosed within 5 years prior to the first dose, excluding radically cured cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, and/or radically resected carcinoma in situ. If other malignant tumors are diagnosed more than 5 years before administration, pathological or cytological diagnosis of intrahepatic lesions is required to determine whether the original malignancy is a recurrence of liver metastasis;
  • Pregnant or lactating women, as well as women with fertility or male patients who are unwilling or unable to use effective contraception;
  • Untreated active hepatitis B (defined as HBsAg-positive simultaneous detection of HBV-DNA copies greater than the upper limit of normal in the laboratory at the site) Note: Hepatitis B subjects who meet the following criteria can also be enrolled: 1) HBsAg (+) and/or HBcAb (+) before first administration, especially HBV replication is active (HBV-DNA≥1000copies/ml or 2000IU/ml), subjects should receive anti-HBV therapy throughout the duration of the study treatment; 2) For subjects with HBcAg (+) and HBsAg(-), HBsAg(-) and HBV viral load (-), prophylactic anti-HBV therapy is not required, but close monitoring for viral reactivation is required;
  • Active HCV-infected subjects (HCV antibody positive and HCV-RNA levels above the lower detection limit);
  • There are any serious or uncontrollable systemic disorders, such as: 1) Have grade II myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval male ≥ 450 ms, female ≥ 470 ms) 2) According to NYHA standard III. to IV. cardiac insufficiency or cardiac color ultrasound examination: LVEF (left ventricular ejection fraction) < 50% 3) Unsatisfactory blood pressure control (systolic blood pressure > 140 mmHg, diastolic blood pressure >90 mmHg); 4) Poor control of diabetes mellitus (fasting blood glucose (FBG) >10mmol/L); 5) Urine routine indicates urine protein ≥++, and confirms that the quantitative > of urine protein in 24 hours is 1.0 g; 6) Patients with mental disorders who cannot cooperate with treatment;
  • Medical history or disease evidence that may interfere with test results, prevent participants from participating in the study throughout the study, abnormal treatment or laboratory test values, or other circumstances that the investigator deems unsuitable for enrolment The investigator considers other potential risks to participate in this study.

Sites / Locations

    Arms of the Study

    Arm 1

    Arm Type

    Experimental

    Arm Label

    HAIC-Donafenib-Toripalimab Group

    Arm Description

    HAIC(FOLFOX)+Toripalimab+Donafenib

    Outcomes

    Primary Outcome Measures

    Conversion therapy success rate
    Defined as the proportion of patients who met the resection criteria after conversion therapy and successfully underwent radical resection surgery to the total number of patients enrolled.

    Secondary Outcome Measures

    Conversion therapy success rate based on imageological examination
    Defined as the proportion of patients who met the resection criteria based on imageological proof after conversion therapy to the total number of patients enrolled.
    Objective response rate (ORR)
    Defined as proportion of patients who have a best response of treatment.
    Disease control rate(DCR)
    Defined as the proportion of cases with remission and stable lesions after treatment was assessable.
    Progression-free survival(PFS)
    Defined as the time from the date of enrollment until the date of objective disease progression or death (by any cause in the absence of progression).
    Overall survival(OS)
    Defined as time from the start of treatment until death due to any reason.
    Recurrence-free survival(RFS)
    Defined as the time from date of randomization until the date of recurrence.
    Time to response(TTR)
    Defined as the time from date of randomization until the date of patients who met a reasonable response to treatment.
    Safety and tolerability(Adverse Events)
    Safety as measured by number and grade of adverse events
    Patient reported outcome(PRO)
    Any potential types of measurement self-reported by the patients.

    Full Information

    First Posted
    August 7, 2022
    Last Updated
    August 16, 2022
    Sponsor
    Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
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    1. Study Identification

    Unique Protocol Identification Number
    NCT05493332
    Brief Title
    HAIC Combined With Donafenib Tosilate and Toripalimab for Unresectable HCC
    Official Title
    A Prospective, Single-armed, Multicentric, Explorative Phase II Clinical Research of Conversional Therapy With Combination of Hepatic Arterial Infusion Chemotherapy and Donafenib and Toripalimab for Unresectable Hepatocellular Carcinoma
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    September 2021
    Overall Recruitment Status
    Not yet recruiting
    Study Start Date
    September 2022 (Anticipated)
    Primary Completion Date
    September 2023 (Anticipated)
    Study Completion Date
    September 2024 (Anticipated)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Sponsor
    Name of the Sponsor
    Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

    4. Oversight

    Studies a U.S. FDA-regulated Drug Product
    No
    Studies a U.S. FDA-regulated Device Product
    No
    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    This is a prospective, single-armed, multicentric, explorative phase II clinical research of conversional therapy with combination of hepatic arterial infusion chemotherapy(HAIC), Donafenib Tosilate and Toripalimab for unresectable hepatocellular carcinoma.
    Detailed Description
    Compared with systemic intravenous chemotherapy, hepatic arterial infusion chemotherapy(HAIC) has the advantages of increasing local drug concentration and reducing systemic toxic and side effects. Currently, it is gradually used in the treatment of hepatocellular carcinoma (HCC) with good safety and high objective response rate. Immunotherapy combined with targeted and chemotherapy was well tolerated. At present, anti-programmed cell death protein-1(PD-1) antibody combined with chemotherapy and targeted therapy for advanced biliary tract tumors has initially shown good safety and encouraging efficacy, which is worthy of further exploration. Therefore, this study aims to evaluate the efficacy and safety of HAIC (FOLFOX) combined with Toripalimab and Donafenib Tosilate in unresectable HCC.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Hepatocellular Carcinoma
    Keywords
    HCC

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Phase 2
    Interventional Study Model
    Single Group Assignment
    Masking
    None (Open Label)
    Allocation
    N/A
    Enrollment
    93 (Anticipated)

    8. Arms, Groups, and Interventions

    Arm Title
    HAIC-Donafenib-Toripalimab Group
    Arm Type
    Experimental
    Arm Description
    HAIC(FOLFOX)+Toripalimab+Donafenib
    Intervention Type
    Procedure
    Intervention Name(s)
    HAIC(FOLFOX)
    Other Intervention Name(s)
    Hepatic Artery Infusion Chemotherapy, FOLFOX
    Intervention Description
    After successful percutaneous hepatic artery cannulation, superior mesenteric arteriogram and hepatic arteriogram were performed, and after confirming that the subjects were eligible for enrollment according to the results, the hepatic artery was cannulated to the predetermined position. The catheter was connected to a syringe pump in the ward for continuous pumping of chemotherapy drugs.
    Intervention Type
    Drug
    Intervention Name(s)
    Oxaliplatin
    Intervention Description
    85mg/m2 IVdrip from hour 0 to 2 on D1,Q3W
    Intervention Type
    Drug
    Intervention Name(s)
    Leucovorin
    Intervention Description
    400mg/m2 IVdrip , from hour 0 to 2 on D1 to D2,Q3W
    Intervention Type
    Drug
    Intervention Name(s)
    Fluorouracil
    Intervention Description
    400mg/m2 , bolus at hour 3 ; and 600mg/m2 IVdrip over 46 hours on D1 to D2,Q3W
    Intervention Type
    Drug
    Intervention Name(s)
    Toripalimab
    Intervention Description
    240mg IVdrip,D3, Q3W
    Intervention Type
    Drug
    Intervention Name(s)
    Donafenib
    Intervention Description
    0.1g. P.O, BID, continuously
    Primary Outcome Measure Information:
    Title
    Conversion therapy success rate
    Description
    Defined as the proportion of patients who met the resection criteria after conversion therapy and successfully underwent radical resection surgery to the total number of patients enrolled.
    Time Frame
    through study completion, an average of 2 year
    Secondary Outcome Measure Information:
    Title
    Conversion therapy success rate based on imageological examination
    Description
    Defined as the proportion of patients who met the resection criteria based on imageological proof after conversion therapy to the total number of patients enrolled.
    Time Frame
    through study completion, an average of 2 year
    Title
    Objective response rate (ORR)
    Description
    Defined as proportion of patients who have a best response of treatment.
    Time Frame
    through study completion, an average of 2 year
    Title
    Disease control rate(DCR)
    Description
    Defined as the proportion of cases with remission and stable lesions after treatment was assessable.
    Time Frame
    through study completion, an average of 2 year
    Title
    Progression-free survival(PFS)
    Description
    Defined as the time from the date of enrollment until the date of objective disease progression or death (by any cause in the absence of progression).
    Time Frame
    through study completion, an average of 2 year
    Title
    Overall survival(OS)
    Description
    Defined as time from the start of treatment until death due to any reason.
    Time Frame
    through study completion, an average of 2 year
    Title
    Recurrence-free survival(RFS)
    Description
    Defined as the time from date of randomization until the date of recurrence.
    Time Frame
    through study completion, an average of 2 year
    Title
    Time to response(TTR)
    Description
    Defined as the time from date of randomization until the date of patients who met a reasonable response to treatment.
    Time Frame
    through study completion, an average of 2 year
    Title
    Safety and tolerability(Adverse Events)
    Description
    Safety as measured by number and grade of adverse events
    Time Frame
    through study completion, an average of 2 year
    Title
    Patient reported outcome(PRO)
    Description
    Any potential types of measurement self-reported by the patients.
    Time Frame
    through study completion, an average of 2 year

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    18 Years
    Maximum Age & Unit of Time
    75 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: Signed an informed consent form, abled to comply with visits and related procedures specified in the program; Age 18-75 years old (including the boundary value), male or female; Zubrod-ECOG-WHO scored 0 to 1; Expected survival time ≥ 12 weeks; Serum AFP detection and imaging examination meet the clinical diagnostic criteria for hepatocellular carcinoma in the "National Health Commission of the People's Republic of China. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)"; Liver function grading: Child-Pugh grade A or better B grade (≤7 points); According to the modified solid tumor efficacy evaluation criteria (mRECIST), at least one imaging measurable lesion; Newly diagnosed hepatocellular carcinoma patients who have not undergone any local or systematic treatment for hepatocellular carcinoma in the past; Patients with hepatocellular carcinoma who have been evaluated by researchers and do not have the conditions for radical resection surgery, but are expected to achieve radical resection through translational therapy, include but are not limited to one of the following situations: The tumor is massive, close to or involves the main intrahepatic ducts, and the surgical margin is expected to be 1 cm or closer to the edge of the tumor, making it difficult to achieve R0 resection; The tumor is large, but limited to the target resection of the liver segment; Tumors with large vascular carcinoma suppositories, such as portal vein primary branch carcinoma suppositories (not entering the main trunk), hepatic vein cancer suppositories (not entering the inferior vena cava), but portal vein cancer embolus can only be limited to one side and cannot affect the contralateral side; Tumor nodules ≥ 4, and mainly concentrated on the side of the liver; other conditions in which the researcher believes that radical resection may be achieved through translational therapy; Full organ and bone marrow function, and the laboratory test values within 7 days before enrollment meet the following requirements (no blood components, cell growth factors, albumin, and other drugs for corrective treatment are allowed within the first 14 days of obtaining laboratory tests), as follows: Blood count: absolute neutrophil count (ANC) ≥ 1.5×10^9/L; Platelet count (PLT) ≥75×10^9/L; Hemoglobin content (hemoglobin, HGB) ≥80g/L; Liver function: serum total bilirubin (TBIL) ≤ 1.5× upper limit of normal value (ULN); Alanine aminotransferase (ALT) and aspartate aminotransase (AST) ≤5×ULN; Serum albumin ≥ 28 g/L; alkaline phosphatase (ALP) ≤5×ULN; Renal function: serum creatinine (creatinine, Cr) ≤ 1.5× ULN or clearance of creatinine (CCr) ≥ 45mL/min (Cockcroft-Gault formula); Urinalysis results show urine protein <2+; Coagulation function: the international normalized ratio (INR) is ≤2, and the activated partial thromboplastin time (APTT) ≤ 1.5 times ULS; Normal thyroid function, defined as thyroid-stimulating hormone (TSH) in the normal range. If the baseline TSH is outside the normal range, subjects with total T3 (or FT3) and FT4 within the normal range can also be enrolled; Myocardial enzyme profile is within the normal range (if the researcher comprehensively judges that it is not clinically significant as a simple laboratory abnormality, it is also allowed to enroll); Female subjects of childbearing age should undergo a negative urine or serum pregnancy test within 7 days prior to receiving the first study drug administration (day 1 of the first cycle). If the results of the urine pregnancy test cannot be confirmed as negative, a blood pregnancy test is required. Women of non-reproductive age are defined as at least 1 year after menopause, or have undergone surgical sterilization or hysterectomy; If there is a risk of conception, all subjects (whether male or female) should use contraception with an annual failure rate of less than 1% throughout the treatment period until 120 days after the last study drug administration of treatment. Exclusion Criteria: Histology contains fibroblast hepatocellular carcinoma, sarcoma-like hepatocellular carcinoma, cholangiocarcinoma and other components; Patients with hepatocellular carcinoma who have previously undergone radical resection and recurrent hepatic cancer; Have received liver transplantation in the past; Have previously received systemic therapy for hepatocellular carcinoma, including targeted drug therapy such as sorafenib, renvatinib, and rigofenib, or immunomodulatory agent therapy such as anti-PD-1, anti-PD-L1/L2, and anti-CTLA-4, excluding antiviral therapy; If the patient has previously used Chinese medicine with anti-tumor indications, he or she must be > 2 weeks or 5 drug half-lives (whichever is longer) after the completion of treatment and before the use of this study; Before starting treatment, there has not been sufficient recovery from toxicity and / or complications caused by any intervention (i.e., ≤ grade 1 or reach baseline, excluding fatigue or hair loss); Patients with any extrahepatic organ or lymph node metastases, including but not limited to: lung metastases, bone metastases, brain metastases or local lymph node metastases; There are tumors in the left and right liver lobes, such as diffuse multiple tumors of the whole liver, tumor infiltration of contralateral phylloscopic vein branches, and concomitant inferior vena cava cancer suppositories, etc. There is no potential possibility of transformable resection; There is difficult to control hepatic encephalopathy, hepatorenal syndrome, ascites, pleural effusion or pericardial effusion; Active bleeding or coagulation abnormalities, bleeding tendencies, or receiving thrombolytic, anticoagulant, or antiplatelet therapy; Major surgical procedures (craniotomy, thoracic or abdominal opening) or unhealed wounds, ulcers, or fractures that have not healed within 4 weeks prior to the first dose. Tissue aspiration biopsy or other minor surgical procedures within 7 days prior to the first administration, with the exception of a venipuncture catheter for the purpose of intravenous infusion; History of gastrointestinal bleeding within the previous 4 weeks or a clear tendency to bleed from the gastrointestinal tract (e.g., known focal active ulcer lesions, fecal occult blood++, gastroscopy if persistent fecal occult blood +), or other conditions determined by the researcher that may cause gastrointestinal bleeding (e.g., severe floor/esophageal varices); History of any arteriovenous thrombosis, embolism or ischemia in the previous 6 months, such as myocardial infarction, unstable angina, deep vein thrombosis, pulmonary embolism, cerebrovascular accident or transient ischemic attack; History of gastrointestinal perforation, abdominal fistula or abdominal abscess within the previous 6 months; Patients with past and current objective evidence of a history of pulmonary fibrosis, interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonia, and severe impairment of lung function; Previously or currently suffering from congenital or acquired immunodeficiency diseases; Active autoimmune diseases requiring systemic therapy or a history of the disease within the previous 2 years (vitiligo, psoriasis, alopecia, or Grave's disease that do not require systemic treatment within the last 2 years, hypothyroidism requiring thyroid hormone replacement therapy only, and patients with type I diabetes who require only insulin replacement therapy can be selected). Known history of primary immunodeficiency. Only patients with positive autoimmune antibodies need to be confirmed as to whether an autoimmune disease is present according to the investigator's judgment; Immunosuppressive drugs have been used within the previous 4 weeks, excluding nasal spray, inhalation or other routes of local glucocorticoids or physiological doses of systemic glucocorticoids (i.e., not more than 10 mg/day prednisone or equivalent doses of other glucocorticoids), allowing the temporary use of glucocorticoids for the treatment of symptoms of dyspnea in the treatment of asthma, chronic obstructive pulmonary disease and other diseases; Attenuated live vaccines were received within the previous 4 weeks or planned for the duration of the study; Other malignancies are diagnosed within 5 years prior to the first dose, excluding radically cured cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, and/or radically resected carcinoma in situ. If other malignant tumors are diagnosed more than 5 years before administration, pathological or cytological diagnosis of intrahepatic lesions is required to determine whether the original malignancy is a recurrence of liver metastasis; Pregnant or lactating women, as well as women with fertility or male patients who are unwilling or unable to use effective contraception; Untreated active hepatitis B (defined as HBsAg-positive simultaneous detection of HBV-DNA copies greater than the upper limit of normal in the laboratory at the site) Note: Hepatitis B subjects who meet the following criteria can also be enrolled: 1) HBsAg (+) and/or HBcAb (+) before first administration, especially HBV replication is active (HBV-DNA≥1000copies/ml or 2000IU/ml), subjects should receive anti-HBV therapy throughout the duration of the study treatment; 2) For subjects with HBcAg (+) and HBsAg(-), HBsAg(-) and HBV viral load (-), prophylactic anti-HBV therapy is not required, but close monitoring for viral reactivation is required; Active HCV-infected subjects (HCV antibody positive and HCV-RNA levels above the lower detection limit); There are any serious or uncontrollable systemic disorders, such as: 1) Have grade II myocardial ischemia or myocardial infarction, poorly controlled arrhythmias (including QTc interval male ≥ 450 ms, female ≥ 470 ms) 2) According to NYHA standard III. to IV. cardiac insufficiency or cardiac color ultrasound examination: LVEF (left ventricular ejection fraction) < 50% 3) Unsatisfactory blood pressure control (systolic blood pressure > 140 mmHg, diastolic blood pressure >90 mmHg); 4) Poor control of diabetes mellitus (fasting blood glucose (FBG) >10mmol/L); 5) Urine routine indicates urine protein ≥++, and confirms that the quantitative > of urine protein in 24 hours is 1.0 g; 6) Patients with mental disorders who cannot cooperate with treatment; Medical history or disease evidence that may interfere with test results, prevent participants from participating in the study throughout the study, abnormal treatment or laboratory test values, or other circumstances that the investigator deems unsuitable for enrolment The investigator considers other potential risks to participate in this study.
    Central Contact Person:
    First Name & Middle Initial & Last Name or Official Title & Degree
    Yongcong Yan
    Phone
    +86 020 34070390
    Email
    yanyc3@mail.sysu.edu.cn
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Zhiyu Xiao
    Organizational Affiliation
    Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
    Official's Role
    Principal Investigator

    12. IPD Sharing Statement

    Plan to Share IPD
    No
    Citations:
    PubMed Identifier
    25752327
    Citation
    Park JW, Chen M, Colombo M, Roberts LR, Schwartz M, Chen PJ, Kudo M, Johnson P, Wagner S, Orsini LS, Sherman M. Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study. Liver Int. 2015 Sep;35(9):2155-66. doi: 10.1111/liv.12818. Epub 2015 Mar 25.
    Results Reference
    background
    PubMed Identifier
    29061175
    Citation
    He MK, Le Y, Li QJ, Yu ZS, Li SH, Wei W, Guo RP, Shi M. Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study. Chin J Cancer. 2017 Oct 23;36(1):83. doi: 10.1186/s40880-017-0251-2.
    Results Reference
    background
    PubMed Identifier
    32979983
    Citation
    Gourd K, Lai C, Reeves C. ESMO Virtual Congress 2020. Lancet Oncol. 2020 Nov;21(11):1403-1404. doi: 10.1016/S1470-2045(20)30585-4. Epub 2020 Sep 24. No abstract available.
    Results Reference
    background
    PubMed Identifier
    31070690
    Citation
    He M, Li Q, Zou R, Shen J, Fang W, Tan G, Zhou Y, Wu X, Xu L, Wei W, Le Y, Zhou Z, Zhao M, Guo Y, Guo R, Chen M, Shi M. Sorafenib Plus Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin vs Sorafenib Alone for Hepatocellular Carcinoma With Portal Vein Invasion: A Randomized Clinical Trial. JAMA Oncol. 2019 Jul 1;5(7):953-960. doi: 10.1001/jamaoncol.2019.0250.
    Results Reference
    background
    PubMed Identifier
    28246584
    Citation
    Bersanelli M, Buti S. From targeting the tumor to targeting the immune system: Transversal challenges in oncology with the inhibition of the PD-1/PD-L1 axis. World J Clin Oncol. 2017 Feb 10;8(1):37-53. doi: 10.5306/wjco.v8.i1.37.
    Results Reference
    background
    PubMed Identifier
    33538338
    Citation
    Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
    Results Reference
    result

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    HAIC Combined With Donafenib Tosilate and Toripalimab for Unresectable HCC

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