PMS Promotes the Recovery of Patients After Heart Valve Replacement (PMS)

Probiotic Mixture Supplementation (PMS) Promotes the Recovery of Patients After Heart Valve Replacement by Preventing Acute Gastrointestinal Injury (AGI)

Acute gastrointestinal injury (AGI) is related to poor outcomes in patients after heart valve replacement. The purpose of this study is to evaluate the effect of the probiotic mixture supplementation (PMS) in patients after heart valve replacement by preventing acute gastrointestinal injury (AGI).

Patients with heart valve diseases often have chronic cardiac insufficiency. Accumulating evidence supports a relationship between the complexity and diversity of the gut microbiota and heart failure. Bacterial colonization and translocation of their toxins to the bloodstream due to altered intestinal permeability are directly correlated with systemic inflammation. The activation of pro-inflammatory pathways and chronic inflammation was hypothesized as a major contributing factor in the pathogenicity and progression of heart failure (HF) Patients undergoing heart valve replacement with cardiopulmonary bypass (CPB) are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI is related to poor outcomes of critically ill patients through many underlying mechanisms. It can leads to infectious complications, multiple organ dysfunction syndromes (MODS), and even death. On the other hand, the supply of probiotics, the good bacteria, is beneficial, despite still having a few controversial results. Therefore, it is important to carefully assess the efficacy of probiotics in the prevention of AGI and other complications in patients undergoing heart valve replacement surgery with CPB, as well as to evaluate the safety of its use.

Dietary Supplements: Probiotic mixture supplementation The Probiotic mixture supplementation contains Lactobacillus acidophilus, Lactobacillus lactis, and Streptococcus lactis.

The AGI score of the patient within the 7th postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.

Feces are collected with sterilized 2 ml tubes and frozen at -80 °C until DNA extraction, preparing for microbe analysis

Blood samples will be collected on the 1st and 3rd days after operation, for analyses of the Interleukin-6

Blood samples will be collected on the 1st and 3rd days after operation, for analyses of the Interleukin-10

Blood samples will be collected on the 1st and 3rd days after operation, for analyses of the NT-ProBNP

Inclusion Criteria: Moderate to severe congestive heart failure (CHF) (NYHA functional class III to IV) Patients with heart valve diseases undergoing CPB cardiac surgery Age > 18 years and ≤ 70 years Exclusion Criteria: Patients with severe low left ventricular function: LVEF ≤ 30% Patients with infective endocarditis Have received major gastrointestinal surgery (including gallbladder and appendectomy) within 5 years Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis Acute gastroenteritis Clostridium difficile or Helicobacter pylori infection Chronic constipation Peptic ulcer Polyps in the stomach or intestines Gastrointestinal neoplasms Abdominal hernia Irritable bowel syndrome Acute or chronic cholecystitis, hepatitis Used antibiotics and probiotics in the past 1 month Patients used antidiarrheals, laxatives, or prebiotics within 1 week Pregnant or pregnant during follow-up Failure to give informed consent (e.g. severe cognitive impairment) The patient has been enrolled in other ongoing clinical trials

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