High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. (Highflow)
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
About this trial
This is an interventional treatment trial for Acute Hypoxemic Respiratory Failure
Eligibility Criteria
Inclusion Criteria:
- Age above 18
- Acute hypoxemic respiratory failure. (Participants admitted with acute hypoxemic respiratory with the following criteria:
RR> 25 breath/minute Use of accessory muscles of respiration, paradoxical breathing, thoracoabdominal asynchrony.
Hypoxemia evidenced by PaO2 / FiO2 ratio <300)
- Acute hypercapnic respiratory failure ((Participants admitted with acute hypercapneic respiratory with the following criteria:
pO2 less than 60 mm Hg (hypoxemia). pCO2 greater than 50 mm Hg (hypercapnia) with pH less than 7.35. Signs and symptoms of acute respiratory distress)
Exclusion Criteria:
- Patients with preprocedural or post-procedural settings (ex: surgery, bronchoscope) post- extubation,
- Patients with cancer or transplant patients,
- Patients less than 18 years old
- Patients with Heart failure patients
- Patients with renal failure patients
- Patients with hemodynamic instability
- Patients with central causes of hypercapnic respiratory failure
- Patients with disturbed conscious level
- Patients who refuse to participate in the study
- Indication for emergency endotracheal intubation
- Tracheotomy or other upper airway disorders
- Active upper gastrointestinal bleeding
Sites / Locations
- Assiut University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Active Comparator
Experimental
Group A1 (NIVMV on hypoxemic)
Group A2 (HFNC on hypoxemic)
Group B1 (NIVMV on hypercapneic)
Group B2 (HFNC on hypercapneic)
Use of NIV on acute hypoxemic respiratory failure patients
Use of HFNC on acute hypoxemic respiratory failure patients
Use of NIV on acute hypercapneic respiratory failure patients
Use of HFNC on acute hypercapneic respiratory failure patients