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High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. (Highflow)

Primary Purpose

Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure

Status
Not yet recruiting
Phase
Not Applicable
Locations
Egypt
Study Type
Interventional
Intervention
High flow nasal cannula (HFNC)
Non-Invasive Mechanical Ventilation (NIV)
Sponsored by
Assiut University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acute Hypoxemic Respiratory Failure

Eligibility Criteria

18 Years - 95 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Age above 18
  • Acute hypoxemic respiratory failure. (Participants admitted with acute hypoxemic respiratory with the following criteria:

RR> 25 breath/minute Use of accessory muscles of respiration, paradoxical breathing, thoracoabdominal asynchrony.

Hypoxemia evidenced by PaO2 / FiO2 ratio <300)

  • Acute hypercapnic respiratory failure ((Participants admitted with acute hypercapneic respiratory with the following criteria:

pO2 less than 60 mm Hg (hypoxemia). pCO2 greater than 50 mm Hg (hypercapnia) with pH less than 7.35. Signs and symptoms of acute respiratory distress)

Exclusion Criteria:

  • Patients with preprocedural or post-procedural settings (ex: surgery, bronchoscope) post- extubation,
  • Patients with cancer or transplant patients,
  • Patients less than 18 years old
  • Patients with Heart failure patients
  • Patients with renal failure patients
  • Patients with hemodynamic instability
  • Patients with central causes of hypercapnic respiratory failure
  • Patients with disturbed conscious level
  • Patients who refuse to participate in the study
  • Indication for emergency endotracheal intubation
  • Tracheotomy or other upper airway disorders
  • Active upper gastrointestinal bleeding

Sites / Locations

  • Assiut University

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Active Comparator

Experimental

Active Comparator

Experimental

Arm Label

Group A1 (NIVMV on hypoxemic)

Group A2 (HFNC on hypoxemic)

Group B1 (NIVMV on hypercapneic)

Group B2 (HFNC on hypercapneic)

Arm Description

Use of NIV on acute hypoxemic respiratory failure patients

Use of HFNC on acute hypoxemic respiratory failure patients

Use of NIV on acute hypercapneic respiratory failure patients

Use of HFNC on acute hypercapneic respiratory failure patients

Outcomes

Primary Outcome Measures

Evaluation of HFNC and NIV in correction of Acidosis .
Evaluation of the effectiveness of HFNC VS NIV in correction of Acidosis through measurement of PH via arterial blood gases test (ABG). Evaluation of the effectiveness of HFNC in correction of Acidosis through measurement of PH via arterial blood gases test (ABG).
Evaluation of HFNC and NIV in correction of Hypercapnia.
Evaluation of the effectiveness of HFNC VS NIV in correction of Hypercapnia through measurement of PCO2 by mmHg via arterial blood gases test (ABG)
Evaluation of HFNC and NIV in management of Acute hypoxemic respiratory failure.
Evaluation of the effectiveness of HFNC VS NIV in management of Acute hypoxemic respiratory failure through measurement of PO2 via arterial blood gases test (ABG)
Evaluation of HFNC and NIV in correction of Hypoxemia.
Evaluation of the effectiveness of HFNC VS NIV in correction of Hypoxemia through measurement of O2 saturation by percentage % via pulse oximeter.
Endotracheal intubation rate.
needs escalation to invasive mechanical ventilation

Secondary Outcome Measures

In hospital mortality.
death
duration of intervention
time needed for ventilatory support
hospital coast
effects on hospital coast
duration of ICU stay .
icu occupancy
development of complications
due to devices

Full Information

First Posted
March 7, 2022
Last Updated
August 27, 2022
Sponsor
Assiut University
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1. Study Identification

Unique Protocol Identification Number
NCT05499039
Brief Title
High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure.
Acronym
Highflow
Official Title
High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure.
Study Type
Interventional

2. Study Status

Record Verification Date
August 2022
Overall Recruitment Status
Not yet recruiting
Study Start Date
October 10, 2022 (Anticipated)
Primary Completion Date
October 10, 2024 (Anticipated)
Study Completion Date
October 20, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Assiut University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No

5. Study Description

Brief Summary
high flow nasal cannula (HFNC) oxygen therapy utilizes an air oxygen blend allowing from 21 % to 1 00% FiO2 delivery and generates up to 60 L/min flow rates The gas is heated and humidified through an active heated humidifier and delivered via a single limb heated inspiratory circuit (to avoid heat loss and condensation) to the patient through a large diameter nasal cannula Theoretically, HFNC offers significant advantages in oxygenation and ventilation over COT. Constant high flow oxygen delivery provides steady FiO2 and decreases oxygen dilution. It also washes out physiologic dead space and generates positive end expiration pressure (PEEP) that augments ventilation The heated humidification facilitates secretion clearance, decreases bronchospasm, and maintains mucosal integrity. This study aims to evaluate the effectiveness of HFNC compared to NIMV in management of Acute hypoxemic and acute hypercapneic respiratory failure
Detailed Description
Acute respiratory failure (ARF) is a common and serious complication among hospitalized patients. It is the most frequent reason for admission to the intensive care unit (ICU) . It carries an in-hospital mortality rate of 20.6% and cost 54.3 billion dollars nationwide in United States in 2009. Among those patients with ARF, 42.1 % of patients require mechanical ventilation (MV), which is associated with a significant increase in both length of stay and medical expense ARF can be categorized into acute hypoxemic respiratory failure(AHRF) and acute hypercapneic respiratory failure. Supplemental oxygen and treatment of the underlying cause is the mainstay of therapy for AHRF. Options for oxygen therapy include conventional oxygen therapy delivered via nasal cannulae (NC) or face masks (FM) initially, followed by non-invasive ventilation (NIV), and finally intubation or mechanical ventilation (MV) . Traditional NC and FM (collectively referred to as conventional oxygen therapy or COT) can achieve flow rates of up to 1 5 L/min. However, these flow rates may be significantly lower than patients' spontaneous inspiratory flow rates and the oxygen is diluted as it is mixed with room air Consequently, the fraction of inspired oxygen (FiO2) delivered Is variable and this is thought to explain why many patients require an escalation of oxygen therapy to NIV or MV. By contrast, humidified high flow nasal cannula (HFNC) oxygen therapy utilizes an air oxygen blend allowing from 21 % to 1 00% FiO2 delivery and generates up to 60 L/min flow rates The gas is heated and humidified through an active heated humidifier and delivered via a single limb heated inspiratory circuit (to avoid heat loss and condensation) to the patient through a large diameter nasal cannula Theoretically, HFNC offers significant advantages in oxygenation and ventilation over COT. Constant high flow oxygen delivery provides steady FiO2 and decreases oxygen dilution. It also washes out physiologic dead space and generates positive end expiration pressure (PEEP) that augments ventilation The heated humidification facilitates secretion clearance, decreases bronchospasm, and maintains mucosal integrity HFNC has been well studied in the neonatal and pediatric settings However, in adults, the use of HFNC has Primarily been studied in post-cardiac surgery post-extubation and bronchoscopy patients. However, the utility of HFNC use in adults with AHRF in emergency and general inpatient practice is less clear .Heated and humidified high-flow oxygen through nasal cannula (HFNC) has been developed over the past 2 decades, as an alternative to standard oxygen delivery systems . In adults, it has been used to treat hypoxemic respiratory failure, cardiogenic pulmonary edema, postoperatively and postextubation in do-not-intubate patients or during bronchoscopy To date, the literature supports the possibility to use HFNC as alternative to non-invasive ventilation (NIV) in some settings, while in others might be even superior . It is also an alternative to standard oxygen as first line therapy in management of patients with acute respiratory failure . NIV is strongly recommended in patients with acute-on-chronic respiratory failure associated with acute respiratory acidosis, the vast majority of whom meet the criteria for Chronic Obstructive Pulmonary Disease (COPD) exacerbation Recently, Studies revealed no difference of the 30-day mortality and intubation rate between NIV and HFNC, in severe acute exacerbation of COPD with moderate, hypercapnic, acute respiratory failure. In a retrospective study, that suggeste that HFNC oxygen therapy was beneficial, even in respiratory failure Type 2, resulting in significant improvement of both oxygenation and hypercapnia. another study also indicated that HFNO leads to a flow-dependent reduction in PaCO2 in patients with stable hypercapnic COPD, due to a washout of the respiratory tract and a functional reduction in dead space Although cumulative evidence supports that HFNC is effective in patients with hypercapnia, randomized studies to compare HFNC vs. NIV in patients with acute, hypercapnic respiratory failure are missing. so the investigator conducting this prospective, randomized, controlled trial, involving patients admitted to the Emergency Department (ED), to compare the efficacy of HFNC versus NIV in the management of acute hypercapnic respiratory failure.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
patients with will be randomly enrolled to either non invasive group or HFNC group and improvement and patient satisfaction will be assessed
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Neither the participant , care provider , the investigator nor the outcome assessor will select patients in both groups , see results of other patients till the end of the study or informed by literature opinion in this intervention
Allocation
Randomized
Enrollment
80 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Group A1 (NIVMV on hypoxemic)
Arm Type
Active Comparator
Arm Description
Use of NIV on acute hypoxemic respiratory failure patients
Arm Title
Group A2 (HFNC on hypoxemic)
Arm Type
Experimental
Arm Description
Use of HFNC on acute hypoxemic respiratory failure patients
Arm Title
Group B1 (NIVMV on hypercapneic)
Arm Type
Active Comparator
Arm Description
Use of NIV on acute hypercapneic respiratory failure patients
Arm Title
Group B2 (HFNC on hypercapneic)
Arm Type
Experimental
Arm Description
Use of HFNC on acute hypercapneic respiratory failure patients
Intervention Type
Device
Intervention Name(s)
High flow nasal cannula (HFNC)
Other Intervention Name(s)
High velocity nasal insufflation (vapotherm)
Intervention Description
High flow nasal cannula consists of an apparatus that allows adjustable FiO2 from 21 to 100% and delivers a modified gas flow up to 60 l/ min . will be set with: - Temperature at 37°C or 34°C Flow rate 30: 50 L/min. FiO2 will be adjusted to achieve a SpO2 at least 95%
Intervention Type
Device
Intervention Name(s)
Non-Invasive Mechanical Ventilation (NIV)
Intervention Description
Respiratory assistance is provided by a NIV either Puritan Bennet 840 , Engström Carestation or Hamilton-G5 , will be used for conventional non-invasive ventilation via an oronasal mask. Settings will be adjusted based on the clinical assessment of the respiratory therapist . Initial setting includes: - Positive End Expiratory Pressure (PEEP): 5 cmH2O. Pressure support (PS): 12-20 cmH2O. FiO2 will be adjusted to achieve a SpO2 at least 95% Intervention: Device: non-invasive ventilation
Primary Outcome Measure Information:
Title
Evaluation of HFNC and NIV in correction of Acidosis .
Description
Evaluation of the effectiveness of HFNC VS NIV in correction of Acidosis through measurement of PH via arterial blood gases test (ABG). Evaluation of the effectiveness of HFNC in correction of Acidosis through measurement of PH via arterial blood gases test (ABG).
Time Frame
Baseline
Title
Evaluation of HFNC and NIV in correction of Hypercapnia.
Description
Evaluation of the effectiveness of HFNC VS NIV in correction of Hypercapnia through measurement of PCO2 by mmHg via arterial blood gases test (ABG)
Time Frame
Baseline
Title
Evaluation of HFNC and NIV in management of Acute hypoxemic respiratory failure.
Description
Evaluation of the effectiveness of HFNC VS NIV in management of Acute hypoxemic respiratory failure through measurement of PO2 via arterial blood gases test (ABG)
Time Frame
Baseline
Title
Evaluation of HFNC and NIV in correction of Hypoxemia.
Description
Evaluation of the effectiveness of HFNC VS NIV in correction of Hypoxemia through measurement of O2 saturation by percentage % via pulse oximeter.
Time Frame
Baseline
Title
Endotracheal intubation rate.
Description
needs escalation to invasive mechanical ventilation
Time Frame
Baseline
Secondary Outcome Measure Information:
Title
In hospital mortality.
Description
death
Time Frame
one month
Title
duration of intervention
Description
time needed for ventilatory support
Time Frame
one month
Title
hospital coast
Description
effects on hospital coast
Time Frame
one month
Title
duration of ICU stay .
Description
icu occupancy
Time Frame
one month
Title
development of complications
Description
due to devices
Time Frame
one month

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
95 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Age above 18 Acute hypoxemic respiratory failure. (Participants admitted with acute hypoxemic respiratory with the following criteria: RR> 25 breath/minute Use of accessory muscles of respiration, paradoxical breathing, thoracoabdominal asynchrony. Hypoxemia evidenced by PaO2 / FiO2 ratio <300) Acute hypercapnic respiratory failure ((Participants admitted with acute hypercapneic respiratory with the following criteria: pO2 less than 60 mm Hg (hypoxemia). pCO2 greater than 50 mm Hg (hypercapnia) with pH less than 7.35. Signs and symptoms of acute respiratory distress) Exclusion Criteria: Patients with preprocedural or post-procedural settings (ex: surgery, bronchoscope) post- extubation, Patients with cancer or transplant patients, Patients less than 18 years old Patients with Heart failure patients Patients with renal failure patients Patients with hemodynamic instability Patients with central causes of hypercapnic respiratory failure Patients with disturbed conscious level Patients who refuse to participate in the study Indication for emergency endotracheal intubation Tracheotomy or other upper airway disorders Active upper gastrointestinal bleeding
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Abdelrahman Mo Alham, Demonstrator
Phone
01014546379
Email
abdoverno@gmail.com
First Name & Middle Initial & Last Name or Official Title & Degree
Peter At Rizk
Phone
01553529181
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Zein Al-abdeen Ah Sayed, professor
Organizational Affiliation
Assiut University
Official's Role
Study Director
First Name & Middle Initial & Last Name & Degree
Taghred SA Meshref, professor
Organizational Affiliation
Assiut University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Assiut University
City
Assiut
Country
Egypt

12. IPD Sharing Statement

Plan to Share IPD
No

Learn more about this trial

High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure.

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