Effects on the Scalp Lipids and TEWL of a 1% Selenium Disulfide and 1% Salicylic Acid Antidandruff Shampoo on Dandruff Scalp

This is an interventional treatment trial for Dandruff Read More

Inclusion Criteria:

• Subject with hair length > 2 cm.
• Subject exhibiting slight to severe dandruff state of scalp: Total dandruff score (adherent + non-adherent) ≥ 4 (ranging from 0 to 10) including and adherent dandruff score ≥ 2.5 (ranging from 0 to 5) and no limit for non-adherent dandruff score, after clinical examination 3 days after the last shampoo performed on D-3.
• Subject with slight itching state of scalp: score before shampoo ≥3 (ranging from 0 to 9,) 3 days after the last shampoo performed on D-3.
• Subject usually using a shampoo 3 times a week and accepting to follow this rate during the whole study period.
• Subject having stopped any possible antidandruff treatment at least 1 week prior to study pre-inclusion.
• Subject usually using anti-dandruff products.
• Subject agreeing not to use any other cosmetic product on the air (tonic,lacquer, gel, mousse) and not colouring or bleaching hair until the end of study

Exclusion Criteria:

• Main Inclusion Criteria:

  • Subject with hair length > 2 cm.
  • Subject exhibiting slight to severe dandruff state of scalp: Total dandruff score (adherent + non-adherent) ≥ 4 (ranging from 0 to 10) including and adherent dandruff score ≥ 2.5 (ranging from 0 to 5) and no limit for non-adherent dandruff score, after clinical examination 3 days after the last shampoo performed on D-3.
  • Subject with slight itching state of scalp: score before shampoo ≥3 (ranging from 0 to 9,) 3 days after the last shampoo performed on D-3.
  • Subject usually using a shampoo 3 times a week and accepting to follow this rate during the whole study period.
  • Subject having stopped any possible antidandruff treatment at least 1 week prior to study pre-inclusion.
  • Subject usually using anti-dandruff products.
  • Subject agreeing not to use any other cosmetic product on the air (tonic,lacquer, gel, mousse) and not colouring or bleaching hair until the end of study

• Main Non-Inclusion Criteria:

  • Subject who has skin marks on the scalp that could interfere with the assessment (pigmentation trouble, scar elements…).
  • Subject who has used topic treatment for the scalp (anti-dandruff, antihairloss) or corticosteroid treatment (per os or topical) during the last two weeks before the start of the study.
  • Subject who has used products for the scalp (dyeing, bleaching, permanent waving and straightening …) within the 2 weeks prior to the study.
  • Subject with personal history of allergy and/or particular reactivity to antidandruff products.
  • Subject with personal history of allergy and/or adverse reactions to cosmetic products containing surfactant agents (soaps, shower gel, conditioner …)
  • Subject who has taken a drug containing lithium, corticoids, during the last month; anti-histaminic, anti-fungal, non-steroidal anti-inflammatory or immunosuppressive drugs during the last 7 days.
  • Subject who has taken retinoid acid (local or per os) since less than 6 months.
  • Subject with cutaneous affection of the scalp (psoriasis, atopic dermatitis, seborrheic dermatitis, alopecia …).
  • Subject affected by serious, non-stabilized or progressive disease (according to the investigator) as diabetes, hypertension, hypothyroidism or hyperthyroidism which may influence the evolution of studied cutaneous state and morphology.
  • Subject affected by serious pathology (cancer, immune-depressed)
  • Subject who has undergone a surgical operation in the previous month of the study or having planned it during the study.
  • Subject, who has started, stopped or changed of hormonal treatment (including contraceptive pill) in the previous 6 weeks.
  • Pregnancy or breastfeeding during the last 6 months, ongoing or planned during the study