In Vitro Evaluation of Spontaneous and Oxytocin-induced Contractility of Pregnant Human Myometrium During Exposure to Dexmedetomidine
Postpartum Hemorrhage
About this trial
This is an interventional treatment trial for Postpartum Hemorrhage focused on measuring uterine contraction, oxytocin, dexmedetomidine
Eligibility Criteria
Inclusion Criteria:
- Pregnant patients scheduled for elective CD under regional anesthesia at 37-41 weeks of gestational age will be included in this study.
- Only patients for primary CD or repeat CD (1x) will be included in this study since excessive uterine scarring from multiple CD may affect the contractility of myometrial sample.
Exclusion Criteria:
- patient refusal
- emergency CD
- general anesthesia
- placenta accreta spectrum disorder
- any condition predisposing the patient to uterine atony (e.g. polyhydramnios, multiple gestation)
- patients taking medications affecting myometrial contractions(labetalol, magnesium etc.).
Sites / Locations
- Mount Sinai HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Dexmedetomidine
Oxytocin
Dexmedetomidine + Oxytocin
Oxytocin pre-treatment followed by Dexmedetomidine
Oxytocin pre-treatment followed by Oxytocin
Oxytocin pre-treatment followed by Dexmedetomidine + Oxytocin
The myometrial samples are bathed in increasing concentrations of dexmedetomidine (from 10 -9M to 10 -4M).
The myometrial samples are bathed in oxytocin 20nM.
The myometrial samples are bathed in oxytocin at 20nM along with dexmedetomidine (10-9M to 10-4M).
The myometrial samples are pre-treated with oxytocin (10-5M) for 2 hours, and then in increasing concentrations of dexmedetomidine (from 10 -9M to 10 -4M).
The myometrial samples are pre-treated with oxytocin (10-5M) for 2 hours, and then bathed in oxytocin at 20nM.
The myometrial samples are pre-treated with oxytocin (10-5M) for 2 hours, and then bathed in oxytocin at 20nM along with dexmedetomidine (10-9M to 10-4M)