Polypill in Acute Coronary Syndrome (POLY-ACS)
Acute Coronary Syndrome, Lipid Disorder, Coronary Artery Disease
About this trial
This is an interventional treatment trial for Acute Coronary Syndrome focused on measuring Acute coronary syndrome, Antiplatlet therapy, Statin, Lipids, Drug eluting stent
Eligibility Criteria
Inclusion Criteria:
1. Patients admitted with acute coronary syndrome who undergo percutaneous coronary intervention with drug eluting stent placement.
Exclusion Criteria:
- Age < 18
- Estimated glomerular filtration rate < 30 mL/min/1.73 m2 as measured by the simplified MDRD formula
- Current need for inotropes or with cardiac index < 2.2 L/min/m2
- History of coronary artery bypass graft surgery
- Current need for systemic anticoagulation
- Contraindication to receive any components of the polypill
- History of allergic reaction or intolerance to aspirin, prasugrel, or rosuvastatin
- Comorbidities that might be expected to limit lifespan within the 1-month study period
- Inability to provide written informed consent
- Pregnancy
Sites / Locations
- UT Southwestern Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Polypill
Usual Care (individual medications prescribed by primary cardiologist)
Patients will be randomized to receiving a fixed-dose polypill in addition to other guideline-directed medical therapies prescribed by their physician. Polypill formulations will include rosuvastatin 40 mg, aspirin 81 mg, and prasugrel 10 mg daily or rosuvastatin 40 mg, aspirin 81 mg, and clopidogrel 75 mg.
Patients will receive usual post-ACS care and medications prescribed by their provider. All of the individual components will be available at low- or no-cost to participants as individual pill formulations.