A Study to Assess the Safety and Efficacy of Vatiquinone in Participants With Friedreich Ataxia
Friedreich Ataxia
About this trial
This is an interventional treatment trial for Friedreich Ataxia
Eligibility Criteria
Inclusion Criteria:
- Participants with FA who completed and directly rolled over from a previous vatiquinone clinical study (PTC743-NEU-003-FA [that is, MOVE-FA] or PTC743-NEU-005-FA).
- Males and females of childbearing potential must be willing to use an effective method of contraception (for example, implants, injectables, transdermal patches, combined oral contraceptives, barrier methods, and intrauterine devices) from the time consent is signed until 30 days after the last dose of study drug or Early Termination Visit.
Exclusion Criteria:
- Current participation in any other interventional study
- Pregnancy or breastfeeding
Sites / Locations
- UCLA
- University of Florida
- University of South Florida
- University of Iowa
- The Children's Hospital of Philadelphia
- Murdoch Children's Research Institute
- University of Campinas (UNICAMP) - School of Medical Sciences, Dept of Neurology
- Centre de Recherche du Centre Hospitalier de l'Université de Montreal (CRCHUM)
- CHU Sainte-Justine
- Hôpital Pitié-Salpêtrière, Institut du Cerveau (Paris Brain Institute)
- Department of Neurology and Hertie-Institute for Clinical Brain Research German Center of Neurodegenerative Diseases (DZNE)
- Ospedale Pediatrico Bambino Gesu' IRCCS
- CBR Neurogenetic Research Clinic, University of Auckland
- Hospital Sant Joan de Déu Barcelona Unidad de Enfermedades Neuromusculares
Arms of the Study
Arm 1
Experimental
Vatiquinone
Participants with FA who were previously treated with vatiquinone at an investigational site and completed participation in a prior PTC Therapeutics (PTC)-sponsored clinical study (PTC743-NEU-003-FA or PTC743-NEU-005-FA) will continue to receive the same dose/formulation of vatiquinone (unless there has been a change in age and/or weight that meets the criteria for a different dose/formulation as described below; dose/formulation will also be changed if participants meet the criteria for a different dose/formulation during study treatment): If <7 years of age, participants will receive an oral solution (100 milligrams [mg]/milliliter [mL]) 3 times a day (TID) at one of the following doses: 15 mg/kilogram (kg) if body weight <13 kg, or 200 mg if body weight ≥13 kg. If ≥7 years of age, participants will receive a capsule formulation (200 mg) orally TID at one of the following doses: 200 mg if body weight ˂25 kg, or 400 mg if body weight ≥25 kg.