Effect of Probiotics as Supplement to Non-surgical Periodontal Treatment

The present study is a double-blinded randomized clinical trial with a duration of 12 weeks . 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks. Clinical measurements and sampling will be performed at baseline, week 6 and week 12. Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters

Computerized randomization only known to the principal investigator, who are not directly involved in data collection or data analysis

In this group participants will receive non-surgical periodontal treatment at baseline, which will for 12 weeks

In this group participants will receive non-surgical periodontal treatment at baseline, which will for 12 weeks

In this group participants will receive probiotic supplements twice a day (morning and evening) for a period of 12 weeks.

In this group participants will receive placebo twice a day (morning and evening) for at period of 12 weeks.

Inclusion Criteria: Periodontitis stage 2-3, Grade B-C, generalized Exclusion Criteria: • Use of systemic antibiotics within the latest three months.

All microbial data will be shared, as these will be uploaded to a publically accessible database. In accordance with GDPR, immunological and clinical data will only be shared as mean (range) values.