Lung Volume Preservation During Extubation
Weaning Failure, Pulmonary Collapse
About this trial
This is an interventional treatment trial for Weaning Failure focused on measuring Weaning from Mechanical Ventilation, Reintubation, Lung Ultrasound Score, Diaphragm and intercostal thickness and thickening fraction
Eligibility Criteria
Inclusion Criteria:
- Patients> 18 years who meet weaning criteria (see below)
- More than 24 hours of mechanical ventilation (MV)
- Signed Informed Consent by a substitute decision maker (SDM).
Weaning Criteria:
- Suitable cough (Ability to raise secretions to the endotracheal tube) (or Maximal inspiratory pressure (MIP) < -15 cmH2O).
- Absence of excessive secretions (<3 aspirations in the last 8 hours).
- Resolution or improvement of the pathology that led to intubation.
- Clinical stability (Heart Rate (HR) <140 bpm, Systolic Blood Pressure (SBP) 90-160, without vasopressors or at minimum doses).
- Adequate oxygenation (SatO2> 90% with Inspiratory Fraction of oxygen (FiO2) <0.4).
- Adequate ventilatory mechanics (Respiratory rate (RR) <35 rpm, Tidal Volume (TV) > 5 ml / kg, RR / TV <100 rpm/l).
- Confident awareness level (Glasgow Coma Scale (GCS)> 13).
Exclusion Criteria:
- tracheostomy, do-not-reintubate orders, decision of the responsible physician (e.g., due to a preference for a particular weaning technique according to the underlying pathology), absence of informed consent, mental incapacity without legal representation.
Sites / Locations
- Althaia Xarxa AssistencialRecruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Standard
Lung Volume Preservation
SBT: PSV 8 cmH2O, PEEP 0 cmH2O for 30 minutes and, when successful, followed by extubation with continuous suctioning. Patients included in the ultrasound nested study: Diaphragm and intercostal thickness and thickening fraction at the beginning and the end of the SBT. Modified LUS at the beginning of the SBT, at the end of the SBT and after extubation if successful SBT.
SBT: PSV 8 cmH2O, PEEP 5 cmH2O for 30 minutes and, when successful, followed by direct extubation without suctioning and connected to the ventilator with PEEP 5 cmH2O. Patients included in the ultrasound part: Diaphragm and intercostal thickness and thickening fraction at the beginning and the end of the SBT. Modified LUS at the beginning of the SBT, at the end of SBT and after extubation if successful SBT.